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Background: Left atrial volume (LAV) and emptying fraction (LAEF) are phasic during cardiac cycle. Their relationships to left ventricular end diastolic pressure (LVEDP) have not been fully defined. Methods: Forty one patients undergoing clinically indicated left heart catheterization were recruited for same day cardiovascular magnetic resonance (CMR). LAV and LAEF were assessed in cine images using biplane area and length method. Three phasic LAV was assessed at LV end systole (LAVmax), LV end diastole (LAVmin) and late LV diastole prior to LA contraction (LAVac). LAEF was assessed as global LAEF (LAEFTotal), passive (LAEFPassive) and active LAEF (LAEFContractile). The relationships of phasic LAV and LAEF to LVEDP were assessed using Receiver operating characteristic comparing areas under the curves (AUC). Results: The mean age of the patients was 59 years. A history of heart failure was present in 16 (39%) with NYHA functional class III or IV in 8 (20%) patients. Average LV ejection fraction was 49 ± 16% ranging from 10% to 74% and LVEDP by catheterization 14 ± 8 mmHg ranging from 4 mmHg to 32 mmHg. LAVmin had the strongest association with LVEDP elevation (>12 mmHg) (AUC 0.765, p = 0.002), as compared to LAVmax (AUC 0.677, p = 0.074) and LAVac (AUC 0.735, p = 0.008). Among three phasic LAEF assessed, LAEFTotal had the closest association with LVEDP elevation (AUC 0.780, p = 0.001), followed by LAEFContractile (AUC 0.698, p = 0.022) and LAEFPassive (AUC 0.656, p = 0.077). Conclusions: Increased LAVmin and decreased LAEFTotal have the best performance in identifying elevated LVEDP among three phasic LAV and LAEF analyzed. Future studies should further characterize LA phasic indices in clinical outcomes. [ABSTRACT FROM AUTHOR]

An abstract of the conference paper "Right ventricular responses to abnormal preload and afterload: a comparison of right ventricular regional displacement by cardiac MRI to elevated right heart pressures by catheterization," by Peter D. Rhee, and colleagues is presented.

An abstract of the conference paper "Association of global and regional central circulation transit time with left ventricular end diastolic pressure using dynamic magnetic resonance imaging," by Ina Vernikouskaya and colleagues is presented.

An abstract of the conference paper "Relationship of left atrial size and function to invasive left ventricular filling pressure: A cardiac MRI study," by Kanna Posina and colleagues is presented.

An abstract of the conference paper "Validating feature tracking MRI for the assessment of strain rate in patients with various hemodyanamic states," by Dvorah Holtzman and colleagues is presented.