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In tolerance to oral anticoagulant drugs may arise as an inborn genetic defect resulting in insensitive hepatic receptor sites to oral anticoagulants or it may be due to one of several acquired causes such as noningestion or malabsorption of the drugs , simultaneous ingestion of barbiturates or the inadvertent consumption of foods with a high vitamin K content. It is an uncommon phenomenon and the genetic defect is usually not recognized until the need for oral anticoagulation arises. We report here a case of resistance to Warfarin in the hope that an awareness of this phenomenon may turn up similar case of study