Search

Your search keyword '"Ikeda, Yoshiyuki"' showing total 12 results
Start Over Author "Ikeda, Yoshiyuki" Journal journal of cardiology
12 results on '"Ikeda, Yoshiyuki"'

2. Author's reply

Author

Hamamoto, Yuki, primary, Tokushige, Akihiro, additional, Yuasa, Toshinori, additional, Ikeda, Yoshiyuki, additional, Horizoe, Yoshihisa, additional, Yasuda, Hisayo, additional, Kubozono, Takuro, additional, and Ohishi, Mitsuru, additional

Published
2023
Full Text
View/download PDF

12. Comparative study of therapeutic effects of shortand long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF).

Author

Miyata, Masaaki, Sasaki, Takeshi, Ikeda, Yoshiyuki, Shinsato, Takuro, Kubozono, Takuro, Furusho, Yuko, Kusumoto, Atsushi, Hamasaki, Shuichi, and Tei, Chuwa

Subjects
HEART failure, BRAIN natriuretic factor, ATRIAL natriuretic peptides, DIURETICS, OUTPATIENT medical care, COMPARATIVE studies, RANDOMIZED controlled trials
Abstract

Background: Loop diuretics have two different classes with different duration of activity: shortacting such as furosemide (duration of activity, 6 h) and long-acting such as azosemide (duration of activity, 10-12 h). We conducted a multicenter, randomized, controlled trial in order to compare the therapeutic effects of azosemide, a long-acting loop diuretic, and furosemide, a short-acting one, on neurohumoral factors and cardiac function in outpatients with chronic heart failure (CHF). Methods: We enrolled 98 patients with CHF who were receiving furosemide and an angiotensinconverting enzyme inhibitor, and they were randomly divided into furosemide (n = 49) and azosemide (n = 49) groups. The furosemide group continued furosemide at the same dosage, and the azosemide group switched from furosemide to azosemide. At baseline and after 3 months, we measured body weight, and levels of brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), norepinephrine, active renin, creatinine, blood urea nitrogen, sodium, potassium, and hematocrit. Chest X-ray and echocardiography were also performed. Results: Body weight and plasma levels of BNP and ANP significantly decreased after 3 months in the azosemide group compared to the furosemide group. There were no significant differences in changes of levels of creatinine, blood urea nitrogen, sodium, potassium, hematocrit, norepinephrine, and active renin after 3 months between the furosemide and azosemide groups. Echocardiography and chest X-ray did not demonstrate significant differences between the two groups. Conclusions: Long-acting azosemide is suggested to be useful for the improvement of neurohumoral factors compared with short-acting furosemide in patients with CHF. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results