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Your search keyword '"Khan, Muhammad Shahzeb"' showing total 20 results
Start Over Author "Khan, Muhammad Shahzeb" Journal journal of cardiac failure
20 results on '"Khan, Muhammad Shahzeb"'

8. Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial

Author

Butler, Javed, Khan, Muhammad Shahzeb, Anker, Stefan D., Fonarow, Gregg C., Kim, Raymond J., Nodari, Savina, O'Connor, Christopher M., Pieske, Burkert, Pieske-Kraigher, Elisabeth, Sabbah, Hani N., Senni, Michele, Voors, Adriaan A., Udelson, James E., Carr, Jim, Gheorghiade, Mihai, and Filippatos, Gerasimos

Published
2020
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11. Minimal Clinically Important Differences in 6-Minute Walk Test in Patients With HFrEF and Iron Deficiency

Author

KHAN, MUHAMMAD SHAHZEB, primary, ANKER, STEFAN D., additional, FRIEDE, TIM, additional, JANKOWSKA, EWA A., additional, METRA, MARCO, additional, PIÑA, ILEANA L, additional, COATS, ANDREW JS, additional, ROSANO, GIUSEPPE, additional, ROUBERT, BERNARD, additional, GOEHRING, UDO-MICHAEL, additional, DORIGOTTI, FABIO, additional, COMIN-COLET, JOSEP, additional, VANVELDHUISEN, DIRK J, additional, FILIPPATOS, GERASIMOS S., additional, PONIKOWSKI, PIOTR, additional, and BUTLER, JAVED, additional

Published
2022
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13. Minimal Clinically Important Difference for Six-minute Walk Test in Patients with HFrEF and Iron Deficiency.

Author

KHAN, MUHAMMAD SHAHZEB, ANKER, STEFAN D., FRIEDE, TIM, JANKOWSKA, EWA A., METRA, MARCO, PIÑA, ILEANA L, COATS, ANDREW JS, ROSANO, GIUSEPPE, ROUBERT, BERNARD, GOEHRING, UDO-MICHAEL, DORIGOTTI, FABIO, COMIN-COLET, JOSEP, VANVELDHUISEN, DIRK J, FILIPPATOS, GERASIMOS S., PONIKOWSKI, PIOTR, BUTLER, JAVED, Piña, Ileana L, and Van Veldhuisen, Dirk J

Abstract

Background: The six-minute walk test (6MWT) is widely used to measure exercise capacity; however, the magnitude of change that is clinically meaningful for individuals is not well established in heart failure with reduced ejection fraction (HFrEF).Objective: To calculate the minimal clinically important difference (MCID) for change in exercise capacity on the 6MWT in iron-deficient HFrEF populations.Methods: In this pooled secondary analysis of FAIR-HF and CONFIRM-HF trials, mean changes in 6MWT from baseline to weeks 12 and 24 were calculated and calibrated against the Patient Global Assessment (PGA) tool [clinical anchor] to derive MCIDs for improvement and deterioration.Results: Of 760 patients included in the two trials, 6MWT and PGA data were available for 680 (89%) and 656 (86%) patients at weeks 12 and 24, respectively. The mean 6MWT distance at baseline was 281±103m. There was a modest correlation between changes in 6MWT and PGA from baseline to week 12 (r=0.31, p<0.0001) and week 24 (r=0.43, p<0.0001). Respective estimates (95% confidence intervals) for MCID in 6MWT at weeks 12 and 24 were 14m (5;23) and 15m (3;27) for a "little improvement" (vs no change), 20m (10;30) and 24m (12;36) for "moderate improvement" vs a "little improvement", -11m (-32;9.2) and -31m (-53;-8) for a "little deterioration" (vs no change), and -84m (-144;-24) and -69m (-118;-20) for "moderate deterioration" vs a "little deterioration".Conclusions: The MCID for improvement in exercise capacity on the 6MWT was 14-15m in patients with HFrEF and iron deficiency. These MCIDs can aid clinical interpretation of study data. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Minimal Clinically Important Difference for Six-minute Walk Test in Patients with HFrEF and Iron Deficiency

Author

Khan, Muhammad Shahzeb, Anker, Stefan D, Friede, Tim, Jankowska, Ewa A, Metra, Marco, Piña, Ileana L, Coats, Andrew Js, Rosano, Giuseppe, Roubert, Bernard, Goehring, Udo-Michael, Dorigotti, Fabio, Comin-Colet, Josep, Van Veldhuisen, Dirk J, Filippatos, Gerasimos S, Ponikowski, Piotr, and Butler, Javed

Subjects
six-minute walk test, minimal clinically important difference, Heart failure with reduced ejection fraction
Abstract

The six-minute walk test (6MWT) is widely used to measure exercise capacity; however, the magnitude of change that is clinically meaningful for individuals is not well established in heart failure with reduced ejection fraction (HFrEF).To calculate the minimal clinically important difference (MCID) for change in exercise capacity on the 6MWT in iron-deficient HFrEF populations.In this pooled secondary analysis of FAIR-HF and CONFIRM-HF trials, mean changes in 6MWT from baseline to weeks 12 and 24 were calculated and calibrated against the Patient Global Assessment (PGA) tool [clinical anchor] to derive MCIDs for improvement and deterioration.Of 760 patients included in the two trials, 6MWT and PGA data were available for 680 (89%) and 656 (86%) patients at weeks 12 and 24, respectively. The mean 6MWT distance at baseline was 281±103m. There was a modest correlation between changes in 6MWT and PGA from baseline to week 12 (r=0.31, p0.0001) and week 24 (r=0.43, p0.0001). Respective estimates (95% confidence intervals) for MCID in 6MWT at weeks 12 and 24 were 14m (5;23) and 15m (3;27) for a "little improvement" (vs no change), 20m (10;30) and 24m (12;36) for "moderate improvement" vs a "little improvement", -11m (-32;9.2) and -31m (-53;-8) for a "little deterioration" (vs no change), and -84m (-144;-24) and -69m (-118;-20) for "moderate deterioration" vs a "little deterioration".The MCID for improvement in exercise capacity on the 6MWT was 14-15m in patients with HFrEF and iron deficiency. These MCIDs can aid clinical interpretation of study data.

Published
2022

18. Reductions in Heart Failure Hospitalizations During the COVID-19 Pandemic

Author

HALL, MICHAEL E., primary, VADUGANATHAN, MUTHIAH, additional, KHAN, MUHAMMAD SHAHZEB, additional, PAPADIMITRIOU, LAMPROS, additional, LONG, ROBERT C., additional, HERNANDEZ, GABRIEL A., additional, MOORE, CHARLES K., additional, LENNEP, BRANDON W., additional, MCMULLAN, MICHAEL R., additional, and BUTLER, JAVED, additional

Published
2020
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