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67 results on '"Hiroshi Ito"'

1. JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure

Author

Koichiro Kinugawa, Yasuko K Bando, Minoru Ono, Shogo Oishi, Hitoshi Nakagawa, Shin-ichi Momomura, Hiroyuki Tsutsui, Miyuki Makaya, Hiroshi Ito, Tomomi Ide, Wataru Shimizu, Kazuhiro Yamamoto, Shun Kosaka, Yasushi Sakata, Yu-ki Iwasaki, Yoshihiko Saito, Atsushi Tanaka, Takeshi Kimura, Shintaro Kinugawa, Isamu Mizote, Masami Kosuge, Toyoaki Murohara, Takashi Akasaka, Koichi Node, Yasuki Kihara, Akiko Okada, and Yoshiharu Kinugasa

Subjects
Heart Failure, medicine.medical_specialty, business.industry, General Medicine, Guideline, medicine.disease, Text mining, Heart failure, Chronic Disease, medicine, Humans, Cardiology and Cardiovascular Medicine, Intensive care medicine, business
Published
2021

2. Increased Cardio-Ankle Vascular Index Is Associated With the Development of Heart Failure in Patients With Preserved Ejection Fraction

Author

Toru Miyoshi, Toru Ooe, Gentaro Shokoku, Hiroshi Ito, Tamaki Ono, Yuko Ohno, Yusuke Kawai, Keisuke Yamamoto, and Koji Tokioka

Subjects
medicine.medical_specialty, Ejection fraction, business.industry, Internal medicine, Heart failure, medicine, Cardiology, In patient, Cardio-ankle vascular index, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2017
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3. 4-Hydroxy-2-nonenal Induces Calcium Overload via the Generation of Reactive Oxygen Species in Isolated Rat Cardiac Myocytes

Author

Soichiro Fuke, Hiromi Matsubara, Hiroshi Ito, Hiroshi Morita, Satoshi Nagase, Daiji Miura, Yoshihisa Fujimoto, Yoshiki Hata, Tohru Ohe, Kazufumi Nakamura, Nobuhiro Nishii, Kengo Fukushima Kusano, and Wakako Sumita-Yoshikawa

Subjects
Male, Antioxidant, medicine.medical_treatment, medicine.disease_cause, Lipid peroxidation, chemistry.chemical_compound, medicine, Animals, Myocytes, Cardiac, Rats, Wistar, Hydrogen peroxide, Cells, Cultured, chemistry.chemical_classification, Aldehydes, Reactive oxygen species, Cell Death, Dose-Response Relationship, Drug, biology, business.industry, Molecular biology, Rats, Biochemistry, chemistry, Catalase, biology.protein, Calcium, Hydroxyl radical, Reactive Oxygen Species, Cardiology and Cardiovascular Medicine, business, Oxidative stress, Intracellular
Abstract

Background It has been reported that that the amount of 4-hydroxy-2-nonenal (HNE), which is a major lipid peroxidation product and a cytotoxic aldehyde, is increased in the human failing myocardium. This study was designed to determine whether HNE has a pro-oxidant effect in cardiac myocytes and whether HNE causes Ca2+ overload. Methods and Results Exposure to HNE for 10 minutes in the presence of ferric nitrilotriacetate induced the production of hydroxyl radical (·OH) in the rat myocardium as assessed by electron spin resonance spectroscopy, and HNE induced the generation of reactive oxygen species (ROS) in a dose-dependent manner as assessed by 2′, 7′-dichlorofluorescein diacetate fluorescence. HNE increased intracellular Ca2+ concentration ([Ca2+]i) as assessed by fura-2 ratio in a dose- and time-dependent manner. After 20 minutes of HNE (400 μmol/L) exposure, hypercontracture was induced in 67% of the cells. Catalase, an antioxidative enzyme that can decompose hydrogen peroxide (H2O2), significantly attenuated the increase in [Ca2+]i and completely inhibited hypercontracture. Carvedilol, a β-blocker with potent antioxidant activity, also significantly attenuated the increase in [Ca2+]i and completely inhibited hypercontracture, but propranolol had no effect on either [Ca2+]i increase or hypercontracture. Conclusions HNE induces the formation of ROS, especially H2O2 and ·OH, in cardiomyocytes and subsequently ROS cause intracellular Ca2+ overload. HNE formation may play an important role as a mediator of oxidative stress in heart failure.

Published
2009
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6. Morphological Determinants of Obstructive Hypertrophic Cardiomyopathy Obtained Using Echocardiography

Author

Takako Iino, Mai Shimbo, Kumiko Watanabe, Wakana Sato, Hiroshi Ito, Ikumi Nara, Hiroyuki Watanabe, and Yuri Umeta

Subjects
Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, Ventricular Outflow Obstruction, 03 medical and health sciences, 0302 clinical medicine, Japan, Predictive Value of Tests, Mitral valve, Internal medicine, medicine, Humans, Ventricular outflow tract, 030212 general & internal medicine, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Hypertrophic cardiomyopathy, Area under the curve, General Medicine, Cardiomyopathy, Hypertrophic, Middle Aged, medicine.disease, Predictive value, medicine.anatomical_structure, ROC Curve, Echocardiography, Anterior mitral leaflet, Cardiology, Female, Obstructive hypertrophic cardiomyopathy, Wall thickness, Cardiology and Cardiovascular Medicine, business
Abstract

The morphological determinants of left ventricular outflow tract (LVOT) obstruction in hypertrophic cardiomyopathy (HCM) are not completely understood. We aimed to identify the anatomical risks of the obstruction using echocardiography.Fifty patients with untreated HCM were classified into two groups: those with LVOT pressure gradient (LVOTPG) ≥ 30 mmHg (obstructive HCM [HOCM] group) and those with LVOTPG < 30 mmHg (HNCM group). The echocardiographic morphological variables were analyzed to determine whether they were predictive of LVOT obstruction. Systolic anterior motions of the mitral valve were observed in 100% of patients in the HOCM group but only in 58% in the HNCM group. There were no significant differences in wall thickness, end-systolic LV dimension (LVDs), or LVOT diameter between the two groups. However, HOCM subjects had a shorter distance from papillary muscles to the inter-ventricular septum (5.97 ± 2.3 versus 9.20 ± 1.9 mm, respectively, P < 0.0001) and a longer anterior mitral leaflet (AML) length (24.7 ± 5.8 versus 20.1 ± 5.4 mm, respectively, P < 0.01) compared to the HNCM group. The AML length/LVDs ratio was significantly higher in the HOCM group compared to the HNCM group (1.02 ± 0.34 versus 0.78 ± 0.26, P < 0.01), and an LVOT obstruction was predicted with an area under the curve of 0.71 (P < 0.05). Multiple linear regression revealed that only the AML length/LVDs ratio was independently associated with LVOTPG (P < 0.01).The AML length/LVDs ratio has a significant predictive value for LVOT obstruction and a strong relationship with LVOTPGs. The AML length/LVDs ratio determines the anatomical risk of LVOT obstruction in HCM.

Published
2017
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7. Beneficial Effects of Early Cardiac Rehabilitation under Left Ventricular Assist System in a Patient with Peripartum Cardiomyopathy: Case Report

Author

Hiroshi Yamamoto, Daichi Takagi, Yoshinori Itagaki, Hiroshi Ito, Shunei Kyo, Genbu Yamaura, Kentaro Kiryu, Takayuki Kadohama, Yoshihumi Chida, and Fuminobu Tanaka

Subjects
medicine.medical_specialty, Rehabilitation, Peripartum cardiomyopathy, business.industry, medicine.medical_treatment, medicine, Cardiology and Cardiovascular Medicine, Intensive care medicine, business, medicine.disease, Beneficial effects
Published
2017
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11. Prosthetic Valves in Pregnancy

Author

Teiji Akagi, Hiroshi Ito, and Norihisa Toh

Subjects
Prosthetic valve, medicine.medical_specialty, Pregnancy, business.industry, medicine, Cardiology and Cardiovascular Medicine, business, medicine.disease, Surgery
Published
2017
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18. Combination with FDG Positron Emission Tomography/computed Tomography (PET/CT) and Electroanatomic Mapping (CARTO) System are Useful for Diagnosing Isolated Cardiac Sarcoidosis

Author

Hiroyuki Watanabe, Katsuhito Seki, Hiroshi Ito, Kenji Iino, Yoshikazu Tamura, Takashi Koyama, and Yuusuke Kobukai

Subjects
PET-CT, medicine.medical_specialty, Electroanatomic mapping, medicine.diagnostic_test, business.industry, medicine, Computed tomography, Cardiac sarcoidosis, Radiology, FDG-Positron Emission Tomography, Cardiology and Cardiovascular Medicine, Nuclear medicine, business
Published
2014
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20. A Right Atrial Giant Lymphoma Causing Right Ventricular Inflow Obstruction

Author

Katsuhito Seki, Yuta Suto, Teruki Sato, Hiroyuki Watanabe, Shin Makabe, Hiroshi Ito, Kenji Iino, Shunsuke Kimura, Takako Iino, and Mai Shimbo

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, Inflow, Cardiology and Cardiovascular Medicine, medicine.disease, business, Right atrial, Lymphoma
Published
2015
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23. Beneficial Effect of Adaptive Servo Ventilation Therapy in Elderly Patients with Severe Heart Failure

Author

Toshiya Fujiwara, Toru Shibahara, Masayasu Nakagawa, Hiroshi Ito, Ikumi Nara, Satoshi Kibira, and Nanami Kamada

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Combination therapy, business.industry, Adaptive servo ventilation, nutritional and metabolic diseases, medicine.disease, Respiratory Medicine, Ezetimibe, Heart failure, Medicine, Rosuvastatin, Cardiology and Cardiovascular Medicine, business, Intensive care medicine, Lipid profile, medicine.drug
Abstract

Comparison of Inflammatory Markers and Lipid Profile Between High-dose Rosuvastatin Monotherapy and Ezetimibe / Rosuvastatin Combination Therapy DAISUKE YAMAZAKI, MASARU ISHIDA, KIYOSHI NOBORI, YASUNORI OGUMA, YUTAKA TERATA, TAKASHI KOYAMA, KENJI IINO, TOSHIMITSU KOSAKA, HIROYUKI WATANABE, HIROSHI ITO Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan

Published
2012
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24. Long-term Effect of Tolvaptan in Patient with Chronic Heart Failure

Author

Toshiya Fujiwara, Hiroshi Ito, Masayasu Nakagawa, Satoshi Kibira, Toru Shibahara, and Ken Ikeda

Subjects
medicine.medical_specialty, business.industry, Heart failure, Internal medicine, Tolvaptan, Cardiology, Medicine, In patient, Term effect, Cardiology and Cardiovascular Medicine, business, medicine.disease, medicine.drug
Published
2014
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25. Beneficial Effects of Adaptive Servo-ventilation Therapy on Microalbuminuria in Patients with Heart Failure

Author

Takashi Koyama, Hiroshi Ito, Yoshikazu Tamura, Kenji Iino, and Hiroyuki Watanabe

Subjects
medicine.medical_specialty, business.industry, Adaptive servo ventilation, Internal medicine, Heart failure, medicine, Cardiology, In patient, Microalbuminuria, Cardiology and Cardiovascular Medicine, medicine.disease, business, Beneficial effects
Published
2014
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29. Effect of Combination Therapy of Oral Beta-blocker and Pimobendan in Patients with Congestive Heart Failure

Author

Michiro Kiryu, Hiroshi Ito, Yuya Aoyama, Hideyuki Hara, and Daisuke Sato

Subjects
medicine.medical_specialty, Combination therapy, business.industry, medicine.drug_class, medicine.disease, Pimobendan, Internal medicine, Heart failure, medicine, Cardiology, In patient, Cardiology and Cardiovascular Medicine, business, Beta blocker, medicine.drug
Published
2006
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32. OptiVol Alert with Low Intrathoracic Impedance Can Predict Increased B-Type Natriuretic Peptide

Author

Tadakatsu Yamada, Atsuyuki Watanabe, Yoji Okamoto, Masayuki Doi, Motoki Kubo, Hiroshi Ito, Satoki Fujii, Nobuhiro Nishii, and Hiroshi Morita

Subjects
medicine.medical_specialty, business.industry, medicine.drug_class, Internal medicine, medicine, Cardiology, Natriuretic peptide, Intrathoracic impedance, Cardiology and Cardiovascular Medicine, business
Published
2013
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33. Bezafibrate Improves Postprandial Hypertriglyceridemia and Postprandial Endothelial Dysfunction in Patients with Metabolic Syndrome

Author

Kazufumi Nakamura, Hiroki Oe, Yuko Ohno, Norihisa Toh, Kunihisa Kono, Hiroshi Ito, Yoko Noda, Hiroshi Morita, and Toru Miyoshi

Subjects
medicine.medical_specialty, Bezafibrate, business.industry, Hypertriglyceridemia, medicine.disease, Postprandial, Endocrinology, Internal medicine, medicine, In patient, Endothelial dysfunction, Metabolic syndrome, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published
2013
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37. Inhibitor of Renin-Angiotensin System Induces Anemia in Patients with Chronic Heart Failure

Author

Yutaka Hirano, Hiroshi Ito, Tohru Masuyama, Nobuyuki Ohte, Takeshi Tsujino, Takashi Akasaka, Satoshi Nakatani, Miho Fukui, Kazuhiro Yamamoto, and Shinichi Hirotani

Subjects
medicine.medical_specialty, Anemia, business.industry, Internal medicine, Heart failure, Renin–angiotensin system, medicine, Cardiology, In patient, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2013
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39. Size of Centrilobular Ground-glass Opacity in Chest CT Examination of Patients with Pulmonary Veno-occlusive Disease and Pulmonary Capillary Hemangiomatosis

Author

Hiroshi Ito, Kengo Kusano, Satoshi Akagi, and Kazufumi Nakamura

Subjects
medicine.medical_specialty, business.industry, medicine, Chest ct, Radiology, Pulmonary capillary hemangiomatosis, Pulmonary Veno-Occlusive Disease, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.disease, Ground-glass opacity
Published
2012
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40. Comparison of Inflammatory Markers and Lipid Profile Between High-dose Rosuvastatin Monotherapy and Ezetimibe / Rosuvastatin Combination Therapy

Author

Yasunori Oguma, Kiyoshi Nobori, Toshimitsu Kosaka, Kenji Iino, Yutaka Terata, Daisuke Yamazaki, Masaru Ishida, Hiroshi Ito, Takashi Koyama, and Hiroyuki Watanabe

Subjects
medicine.diagnostic_test, Combination therapy, Ezetimibe, business.industry, medicine, Rosuvastatin, Pharmacology, Cardiology and Cardiovascular Medicine, Lipid profile, business, medicine.drug
Published
2012
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41. Impact of Short-duration Adaptive Servo-ventilation Therapy on Cardiac Function in Patients with Heart Failure

Author

Takashi Koyama, Hiroshi Ito, Yoshikazu Tamura, Shigenori Terada, Ken Ikeda, Gen Igarashi, and Hiroyuki Watanabe

Subjects
Cardiac function curve, medicine.medical_specialty, business.industry, Internal medicine, Heart failure, Adaptive servo ventilation, Cardiology, Medicine, In patient, Cardiology and Cardiovascular Medicine, business, medicine.disease, Short duration
Published
2012
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42. Impairment of Left Ventricular Diastolic Function in Patients with Chronic Kidney Disease and Ischemic Heart Disease -Assessment by Myocardial SPECT

Author

Takashi Koyama, Hiroyuki Watanabe, Wakana Sato, Kenji Iino, Toshimitsu Kosaka, Masaru Ishida, and Hiroshi Ito

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, In patient, Diastolic function, Disease assessment, Cardiology and Cardiovascular Medicine, medicine.disease, Ischemic heart, business, Kidney disease
Published
2012
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43. Remote Ischemic Pre-conditioning Attenuates the Contrast-induced Kidney Injury in Patients with Moderate Chronic Kidney Disease

Author

Hiroshi Ito, Masaru Ishida, Gen Igarashi, Toshimitsu Kosaka, Hiroyuki Watanabe, Takashi Koyama, and Kenji Iino

Subjects
medicine.medical_specialty, business.industry, media_common.quotation_subject, Urology, medicine.disease, Pre conditioning, Kidney injury, Medicine, Contrast (vision), In patient, Cardiology and Cardiovascular Medicine, business, media_common, Kidney disease
Published
2012
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44. Adaptive-Servo-Ventilation Therapy Improves Cardiac Sympathetic Activity in Heart Failure Patients Coexisting Sleep Disordered Breathing

Author

Hiroshi Ito, Hiroyuki Watanabe, Masaru Ishida, Shigenori Terada, and Takashi Koyama

Subjects
medicine.medical_specialty, Sleep and breathing, business.industry, Heart failure, Adaptive servo ventilation, Internal medicine, Sleep disordered breathing, medicine, Cardiology, Sympathetic activity, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2011
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45. Diagnostic Value of Antegrade Diastolic Pulmonary Artery Flow with Heart Failure

Author

Kumiko Takahashi, Takako Iino, Hiroshi Ito, and Hiroyuki Watanabe

Subjects
medicine.medical_specialty, business.industry, Diastole, medicine.disease, Flow (mathematics), Heart failure, medicine.artery, Internal medicine, Pulmonary artery, medicine, Cardiology, Cardiology and Cardiovascular Medicine, Pulmonary wedge pressure, business, Value (mathematics)
Published
2011
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50. Adaptive Servo Ventilation Improves Cardiac Function in Patients With Chronic Heart Failure Through the anti-Inflammatory Actions

Author

Toshimitsu Kosaka, Hiroshi Ito, Kenji Iino, Wakana Sato, Hiroyuki Watanabe, Takashi Koyama, Yoshiko Munehisa, Shin Makabe, and Yusuke Kobukai

Subjects
Cardiac function curve, medicine.medical_specialty, business.industry, Adaptive servo ventilation, Heart failure, Internal medicine, medicine, Cardiology, In patient, Cardiology and Cardiovascular Medicine, medicine.disease, business, Intensive care medicine
Published
2009
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