1. New stigmastane type of steroidal glycosides from the roots of Vernonia cumingiana.
- Author
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Ma, Guo-Xu, Feng, Wei, Sun, Zhong-Hao, Li, Peng-Fei, Zhu, Nai-Liang, Yang, Jun-Shan, Xu, Xu-Dong, and Wu, Hai-Feng
- Subjects
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GLYCOSIDES , *VERNONIA , *PLANT roots , *STEROIDS , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *CELL-mediated cytotoxicity - Abstract
Two new stigmastane type of steroidal glycosides, vernoniacums A and B (1 and 2), with a Δ7,9(11) steroidal core were isolated from the roots of Vernonia cumingiana. Their structures were elucidated based on various spectroscopic techniques, including IR, HR-FAB-MS, and 1D and 2D NMR. Both compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cells, and compound 1 showed mild activity against the tested cell lines with IC50 values of 15.8 and 35.7 pounds were evaluated for their cytotoxicity against HeLa and HCT-8 cells, and compound 1 showed mild activity against the tested cell lines with IC50 values of 15.8 and 35.7 µM, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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