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The article focuses on a study which analyzed the skeletal response to parathyroid hormone (PTH) in mouse models with manipulated endocrine or autocrine/paracrine insulin-like growth factor 1 (IGF-1). In this study, a mice with hepatic IGF-1 transgene (HIT) and an lgf-1 null mice with blunted IGF-1 expression in tissues were used. It revealed a higher skeletal response to PTH among HIT mice compared to the controls. It is concluded that PTH anabolic action enhancement depends on tissue IGF-1.

The article presents a study which determined the effects of insulin-like growth factor 1 (IGF-1) on body size and skeletal properties without tissue IGF-1. The results of the study showed that an increase of IGF-1 serum made up for the lack of locally-produced IGF-1 since deficits in the early skeletal structures of test mice in the early stages were restored to normal levels by adulthood. The study concluded that a maintenance with elevations of serum IGF-1 suffices to bring about normal body size and composition of the body of test mice.