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Gebre Teklu,1 Mikias Negash,2 Tsegay Asefaw,1 Feven Tesfay,1 Gebreslassie Gebremariam,1 Gebreyohannes Teklehaimanot,1 Mistire Wolde,2 Aster Tsegaye2 1Department of Medical Laboratory Science, College of Health Sciences, Mekelle University, Mekelle, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gebre Teklu Email gebreteklu30@gmail.comAster Tsegaye Email tsegayeaster@yahoo.comBackground: The adverse health effects of chronic gasoline exposure may be related to impairment of the hematopoietic system with bone marrow suppression, an increased risk of blood cell morphology abnormality and developing cancer.Objective: To assess the effect of gasoline exposure on hematological parameters among gas station workers in Mekelle City, Tigray Region, Northern Ethiopia.Methods: This cross-sectional study was carried out on 43 subjects (exposed group) and 77 subjects (unexposed group) with matched age and sex. Socio-demographic characteristics and duration of exposure data were collected using a structured questionnaire and an observation checklist. Sysmex XP-300 was used for hematological analysis and stained peripheral blood smear was examined for any abnormality. Data were entered and analyzed using SPSS version 23.Results: Of exposed individuals, 28/43 (65.1%) and 49/77 (63.6%) of controls were males. The average exposure time was 5.19± 4.38 years, with an average working hour of 11.74± 1.89 hours/day. The mean RBC count (1012/L), HCT (%), HGB (g/dl) and platelets count (109/L) of the exposed group were significantly lower (4.88± 0.573, 43.29± 3.71, 15.04± 1.33 and 248.95± 58.19) compared with controls (5.35± 0.533, 44.95± 3.10, 15.59± 1.26 and 292.45± 62.17) at p< 0.05, respectively. The MCH (pg) (30.48± 2.06 vs 29.52± 1.66) and MCHC (g/dl) (34.83± 0.988 vs 34.32± 0.927) were significantly higher in the exposed group compared with controls (p< 0.05). HCT, RBC, HGB and platelet counts were significantly decreased with increased years of exposure (p< 0.05). The peripheral blood film examination revealed basophilic stippling and macrocytosis in 9.3% of the exposed group.Conclusion: Long-term exposure to gasoline at gas stations affected RBC parameters and platelet count. A significant negative correlation was noted between duration of exposure and HGB, HCT and platelet count, warranting implementation of protective measures at gas stations.Keywords: gas station, gasoline, hematological parameters, petroleum