1. New hydroxyapatite nanophases with enhanced osteogenic and anti-bacterial activity
- Author
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Monica Montesi, Anna Tampieri, Alberto Ballardini, Silvia Panseri, Alberta Vandini, P. G. Balboni, and Simone Sprio
- Subjects
Materials science ,Magnesium ,0206 medical engineering ,Metals and Alloys ,Biomedical Engineering ,chemistry.chemical_element ,02 engineering and technology ,Surgical procedures ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,Apatite ,Biomaterials ,chemistry ,Chemical engineering ,visual_art ,Ceramics and Composites ,visual_art.visual_art_medium ,Gallium ,Anti bacterial ,0210 nano-technology ,Bone regeneration ,Magnesium ion ,Biomedical engineering - Abstract
The present work describes the synthesis and characterization of new apatite phases co-doped with gallium, magnesium and carbonate, exhibiting osteogenic and antibacterial ability. The apatites are synthesized at low temperature to retain nanocrystallinity and controlled doping with the various bioactive foreign ions, as assessed by physico-chemical and crystallographic analyses, reporting the achievement of single phases with reduced crystal ordering. The analysis of single and multi-doped apatites reports to different mechanisms acting in the incorporation of gallium and magnesium ions in the apatite structure. The release of bioactive ions is correlated to the behaviour of human mesenchymal stem cells and of different bacterial strands, selected among the most frequently affecting surgical procedures. Enhanced osteogenic and antibacterial ability is assessed in multi-doped apatites, thus suggesting potential future applications as new smart biomaterials integrating a significant boosting of bone regeneration with adequate protection against bacteria. This article is protected by copyright. All rights reserved.
- Published
- 2017