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Previous investigation implicated surface charge and surface energy as factors which affect blood clotting. The present paper attempts to explore the theoretical basis for these affects. Expressions are also derived relating change and interfacial tension to the binding constants of the protein. Finally, the possibility of phase transition of the adsorbed protein is discussed and techniques for detecting such changes from adsorption measurements are presented.

A design theory is developed for a compact artificial kidney utilizing microcapsules containing urease, ion exchange resin, and adsorbents for uric acid and creatinine. It is shown that the critical factor is the permeability property of the microcapsule wall and that an artificial kidney 10 cm in length and 2 cm in diameter is feasible.

The properties of the three main classes of orthopedic alloys (316L steel, Co-Cr alloys and titanium) are discussed, while all show good general corrosion resistance, the 316L steel have a tendency toward crevice corrosion. Fatigue fracture due to poor design and fabrication defects is discussed. A summary of some problems associated with the evaluation of tissue response is presented. Finally, a review of several new trends toward achieving tissue adhesion is presented.

A theory for the behavior of anodes as stimulus electrodes, particularly as pacemaker electrodes, is presented. Expressions are obtained for the minimum duration and energy of the stimulus. These expressions are applied to that for the dissolution of the anode and transport of the resulting ions in the tissue in order to obtain an estimate of the extent of penetration. Comparison with experimental data indicates good agreement.