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Guided tissue regeneration is a standard surgical treatment for periodontal regeneration. For the purpose of producing a novel guided tissue regeneration membrane with antibacterial activity and osteogenesis, coaxial electrospinning was utilized to manufacture core/shell structure fiber mats. Polyvinylpyrrolidone loaded with naringin was worked as the core of the fiber to enrich osteogenesis and poly(lactic-co-glycolic acid)–Poly- l -lactic acid–Poly- dl -lactic acid loaded with metronidazole was designed as the shell of the fiber to prevent or treat infections caused by bacteria. The loaded metronidazole with an initial short-term release and the loaded naringin with a long-term sustainable release allowed the membranes with multifunction of antibacterial activity and boosting the proliferation of osteoblast with improved osteogenesis, respectively. The fibrous membrane also shielded osteoblast and fibroblasts from ingrowth. The study provided a simple coaxial electrospinning crafts for fabricating multifunctional guided tissue regeneration membranes. A graphical abstract is available online as a supplementary material. [ABSTRACT FROM AUTHOR]