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Your search keyword '"Anastasi, E."' showing total 7 results
Start Over Author "Anastasi, E." Journal journal of biological regulators and homeostatic agents
7 results on '"Anastasi, E."'

1. Serum 25-hydroxy vitamin D levels in essential hypertension

Author

Granato, T., Anastasi, E., Viggiani, V., Occhiuzzi, F., Antonio Angeloni, Gradini, R., and Suppa, M.

Subjects
Adult, Aged, 80 and over, hypertension, Sodium, vitamin D, disease management, Middle Aged, Potassium, Humans, Calcium, Essential Hypertension, Vitamin D, Biomarkers, Aged
Abstract

Vitamin D may have prognostic value in hypertension patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with essential hypertension and to evaluate its prognostic utility. Forty-eight consecutive patients (40 Caucasian and 8 Asian) aged between 30 and 80 years (mean 61.5, range 34-84 years), were enrolled in the study. The main exclusion criteria were age less than 18 years, kidney failure, onco-hematologic disease, hypo-hyperparathyroidism, osteoporosis, treatment with bisphosphonate or 25(OH) vitamin D supplementation. Of the 48 patients included in the study, hyperlipidemia was described in 28, diabetes type 2 in 8, and ischemic heart disease in 14. Serum electrolytes, calcium, sodium, and potassium concentrations were within normal range. Low 25(OH) vitamin D levels inversely correlated with essential hypertension values (p less than 0.001) were considered extremely significant. The determination of 25(OH) vitamin D levels in patients with essential hypertension could improve the research for possible underlying conditions, which should be managed meticulously according to current guidelines.

Published
2018

2. Serum 25-hydroxy vitamin D concentration in acute coronary syndrome

Author

Anastasi, E., Suppa, M., Viggiani, V., Tartaglione, S., Antonio Angeloni, and Granato, T.

Subjects
Adult, Male, cardiovascular disease (CVD), 25(OH)vitamin D, Myocardial Infarction, Middle Aged, acute coronary syndrome (ACS), Troponin T, troponin T hs, procalcitonin, Humans, Female, Acute Coronary Syndrome, Vitamin D, Aged
Abstract

Vitamin D may have prognostic value in cardiovascular disease (CVD) patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with acute coronary syndrome (ACS) and to evaluate its prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between 40 and 70 years (mean 61.5, range 43-77 years) were enrolled in the study. All patients were admitted to the Emergency Department with chest pain and suspected ACS. The main exclusion criteria were age18 years, kidney failure, onco-haematological disease, hypo-hyperparathyroidism, hypo/hyperthyroidism, osteoporosis, treatment with bisphosphonate or 25(OH) vitamin D supplementation. Of the 48 subjects included in the study, thoracic pain symptoms were described in 12 patients with unstable angina (UA) and in 6 patients with ST elevation myocardial infarction (STEMI) and in 30 patients with non-ST-elevation myocardial infarction (NSTEMI). Low 25(OH) vitamin D levels correlated with the presence of ACS (p0.02) and inversely correlated with Troponin T hs (TnT hs) levels (p0.03). The determination of 25(OH) vitamin D levels in combination with TnT hs could improve the research for possible underlying conditions, and these should be managed meticulously according to current guidelines.

Published
2017

5. Performance assessment of a fully automated electro-chemiluminescence immunoassay system for serum S100B protein.

Author

Anastasi E, Gennarini G, Del Monte C, Colaprisca B, Tartaglione S, Di Segni C, and Angeloni A

Subjects
Adult, Aged, Aged, 80 and over, Electrochemical Techniques methods, Female, Humans, Male, Middle Aged, Young Adult, Biomarkers blood, Enzyme-Linked Immunosorbent Assay methods, Luminescent Measurements methods, S100 Calcium Binding Protein beta Subunit blood
Abstract

The altered expression levels of S100 proteins can lead to four different categories of diseases: diseases of the heart and of the central nervous system, inflammatory disorders and cancer. Various studies have shown the lack of harmonization of the results obtained with different methods, mainly due to different performances and measurements of S100B. The purpose of this work was to compare quantitatively the fully automated Elecsys® immunoassay with the reference immunoenzimatic method CanAg® EIA for serum S100B protein. In the study serum samples were analyzed of 161 patients: 85 females (aged 22-83 years) and 76 males (aged 16-90 years), affected by oncological and non-oncological pathologies. Passing–Bablok regression was used to analyze the comparison between the assays; it showed a strong interassay correlation: r = 0.9350 (95% CI =0.9122 – 0.9520), with an intercept of 0.02063 (95% CI=-0.02850 – 0.01400) and a slope of 1.1125 (95% CI=1.0200 – 1.2417). Elecsys® S100 assay should be preferred to CanAg® S100 for better standardization, good reliability and precision but also with the aim to reduce costs and obtain results in a shorter time.

Published
2018

6. Assessing the association between 25-OH vitamin D levels and ROMA score in a population of obese women.

Author

Anastasi E, Capoccia D, Granato T, Viggiani V, Tartaglione S, Manganaro L, Angeloni A, and Leonetti F

Subjects
Adult, Algorithms, Bone Density, Carcinoma, Ovarian Epithelial, Enzyme-Linked Immunosorbent Assay, Female, Humans, Middle Aged, Neoplasms, Glandular and Epithelial blood, Neoplasms, Glandular and Epithelial complications, Obesity complications, Ovarian Neoplasms blood, Ovarian Neoplasms complications, ROC Curve, Risk Factors, Sensitivity and Specificity, Vitamin D blood, Young Adult, Biomarkers, Tumor blood, Obesity blood, Vitamin D analogs & derivatives
Abstract

The “Risk of Malignancy Algorithm” (ROMA) combines the diagnostic power of the CA125 and HE4 markers with menopausal status to predict the risk for developing epithelial ovarian cancer (EOC). The aim of this study was to evaluate the association between 25-OH vitamin D levels and ROMA score in obese women. One hundred and eighteen patients with a Body Mass Index (BMI) > 30 kg/m2 (Group 1) and 80 women with a BMI less than 25 kg / m² (Group 2) were studied. The 25-OH vitamin D was quantified with LUMIPULSE® G 1200. As a threshold value, identified by ROC curve analysis, 20.2 ng/ mL (sensitivity 73.3%, specificity 84%) was chosen corresponding to the limit between sufficient and insufficient 25-OH vitamin D according to the World Health Organization (WHO). Low 25-OH vitamin D levels were observed in 64% of obese women and in 11% of normal-weight women (p less than 0.001). ROMA score above 13% was detected only in obese women (19%). An association between low levels of 25-OH vitamin D and ROMA score was observed. Indeed, 64% of obese women with ROMA score >13% had concomitant insufficient levels of 25-OH vitamin D, while only 36% of obese women with ROMA score >13% had sufficient 25-OH vitamin D levels (p less than 0.0001). This study suggests that the deficiency of 25- OH vitamin D in obese women has a possible correlation with high ROMA score.

Published
2016

7. Endometriosis and Glanzmann’s thrombasthenia.

Author

Imperiale L, Manganaro L, Ticino A, Piacenti I, Anastasi E, Resta S, Benedetti Panici P, and Porpora MG

Subjects
Adult, Contraceptives, Oral, Hormonal adverse effects, Contraceptives, Oral, Hormonal therapeutic use, Disease Susceptibility, Diseases in Twins, Endometriosis diagnostic imaging, Endometriosis drug therapy, Endometriosis surgery, Factor VIIa therapeutic use, Female, Hematometra etiology, Hemorrhagic Disorders drug therapy, Hemorrhagic Disorders etiology, Humans, Intrauterine Devices, Medicated, Levonorgestrel therapeutic use, Medroxyprogesterone Acetate therapeutic use, Menorrhagia etiology, Ovarian Diseases diagnostic imaging, Ovarian Diseases drug therapy, Ovarian Diseases etiology, Ovarian Diseases surgery, Perioperative Care, Recombinant Proteins therapeutic use, Rectal Diseases diagnostic imaging, Rectal Diseases drug therapy, Rectal Diseases etiology, Thrombasthenia genetics, Tranexamic Acid therapeutic use, Triptorelin Pamoate therapeutic use, Vaginal Diseases diagnostic imaging, Vaginal Diseases drug therapy, Vaginal Diseases etiology, Endometriosis etiology, Thrombasthenia complications
Abstract

Glanzmann’s thrombasthenia (GT) is a rare bleeding syndrome characterized by deficiency or defect of platelet aggregation complex. The pathogenesis of endometriosis is controversial but the strongest evidence leans towards retrograde menstruation. GT probably predisposes to endometriosis. The management of women affected by this disease can be difficult due to the risk of bleeding complications, especially during surgical treatment. We describe the cases of three sisters affected by endometriosis and GT, referred to our Department, who received different therapeutic management.

Published
2016

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