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Your search keyword '"Ripoll-Rozada, Jorge"' showing total 5 results
Start Over Author "Ripoll-Rozada, Jorge" Journal journal of biological chemistry
5 results on '"Ripoll-Rozada, Jorge"'

1. In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency

Author

Nesbitt, Natasha M., primary, Zheng, Xiliang, additional, Li, Zongdong, additional, Manso, José A., additional, Yen, Wan-Yi, additional, Malone, Lisa E., additional, Ripoll-Rozada, Jorge, additional, Pereira, Pedro José Barbosa, additional, Mantle, Timothy J., additional, Wang, Jin, additional, and Bahou, Wadie F., additional

Published
2018
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2. Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae

Author

Pirone, Luciano, primary, Ripoll-Rozada, Jorge, additional, Leone, Marilisa, additional, Ronca, Raffaele, additional, Lombardo, Fabrizio, additional, Fiorentino, Gabriella, additional, Andersen, John F., additional, Pereira, Pedro José Barbosa, additional, Arcà, Bruno, additional, and Pedone, Emilia, additional

Published
2017
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5. In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors havingnanomolar potency.

Author

Nesbitt, Natasha M., Xiliang Zheng, Zongdong Li, Manso, José A., Wan-Yi Yen, Malone, Lisa E., Ripoll-Rozada, Jorge, Pereira, Pedro José Barbosa, Mantle, Timothy J., Jin Wang, and Bahou, Wadie F.

Subjects
*REDUCTASE inhibitors, *FLAVIN mononucleotide, *NAD (Coenzyme), *BRASSINOSTEROIDS, *PLATELET count, *REDUCTASES, *HYDROCARBONS
Abstract

eme cytotoxicity is minimized by a two-step catabolic reaction that generates biliverdin (BV) and bilirubin (BR) tetrapyrroles. The second step is regulated by two non-redundant biliverdin reductases (IXα (BLVRA) and IX&3946; (BLVRB)), which retain isomeric specificity and NAD(P)H-dependent redox coupling linked to BR's antioxidant function. Defective BLVRB enzymatic activity with antioxidant mishandling has been implicated in metabolic consequences of hematopoietic lineage fate and enhanced platelet counts in humans. We now outline an integrated platform of in silico and crystallographic studies for the identification of an initial class of compounds inhibiting BLVRB with potencies in the nanomolar range. We found that the most potent BLVRB inhibitors contain a tricyclic hydrocarbon core structure similar to the isoalloxazine ring of flavin mononucleotide and that both xanthene- and acridine-based compounds. [ABSTRACT FROM AUTHOR]

Published
2018
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