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Your search keyword '"Ding, Han-Fei"' showing total 10 results
Start Over Author "Ding, Han-Fei" Journal journal of biological chemistry
10 results on '"Ding, Han-Fei"'

4. Brain-selective Kinase 2 (BRSK2) Phosphorylation on PCTAIRE1 Negatively Regulates Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

Author

Chen, Xin-Ya, primary, Gu, Xiu-Ting, additional, Saiyin, Hexige, additional, Wan, Bo, additional, Zhang, Yu-Jing, additional, Li, Jing, additional, Wang, Ying-Li, additional, Gao, Rui, additional, Wang, Yu-Fan, additional, Dong, Wei-Ping, additional, Najjar, Sonia M., additional, Zhang, Chen-Yu, additional, Ding, Han-Fei, additional, Liu, Jun O., additional, and Yu, Long, additional

Published
2012
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9. Lineage-specific Signaling in Melanocytes

Author

Price, E. Roydon, primary, Ding, Han-Fei, additional, Badalian, Tina, additional, Bhattacharya, Shoumo, additional, Takemoto, Cliff, additional, Yao, Tso-Pang, additional, Hemesath, Timothy J., additional, and Fisher, David E., additional

Published
1998
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10. NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells.

Author

Zhang B, Wang Z, Ding J, Peterson P, Gunning WT, and Ding HF

Subjects
Animals, Epithelial Cells cytology, Fluorescent Antibody Technique, Mice, Mice, Knockout, NF-kappa B genetics, Autoimmune Diseases physiopathology, NF-kappa B physiology, Thymus Gland cytology
Abstract

Medullary thymic epithelial cells function as antigen-presenting cells in negative selection of self-reactive T cell clones, a process essential for the establishment of central self-tolerance. These cells mirror peripheral tissues through promiscuous expression of a diverse set of tissue-restricted self-antigens. The genes and signaling pathways that regulate the development of medullary thymic epithelial cells are not fully understood. Here we show that mice deficient in NF-kappaB2, a member of the NF-kappaB family, display a marked reduction in the number of mature medullary thymic epithelial cells that express CD80 and bind the lectin Ulex europaeus agglutinin-1, leading to a significant decrease in the extent of promiscuous gene expression in the thymus of NF-kappaB2(-/-) mice. Moreover, NF-kappaB2(-/-) mice manifest autoimmunity characterized by multiorgan infiltration of activated T cells and high levels of autoantibodies to multiple organs. A subpopulation of the mice also develops immune complex glomerulonephritis. These findings identify a physiological function of NF-kappaB2 in the development of medullary thymic epithelial cells and, thus, the control of self-tolerance induction.

Published
2006
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