1. SUMO-specific Protease 1 Regulates Mitochondrial Biogenesis through PGC-1α
- Author
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Jianmin Gu, Xuefeng Xia, Rong Cai, Tingting Yu, Song Xue, Edward T.H. Yeh, Chao Huang, Xiaobing Liu, and Jinke Cheng
- Subjects
SENP1 ,Mitochondrial Turnover ,SUMO protein ,Mitochondrion ,Biology ,Biochemistry ,Mice ,Endopeptidases ,Coactivator ,Animals ,Humans ,Molecular Biology ,Mice, Knockout ,urogenital system ,Sumoylation ,Cell Biology ,Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ,Mitochondria ,Cell biology ,Cysteine Endopeptidases ,HEK293 Cells ,Mitochondrial biogenesis ,Trans-Activators ,PPARGC1A ,Biogenesis ,Transcription Factors - Abstract
Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a master regulator of mitochondrial biogenesis in response to changes in the cellular environment, physiological or pathological status of mammals. PGC-1α is known to be modified by SUMO (Small Ubiquitin-like Modifier). However, it is not known whether SUMOylation could affect the function of PGC-1α in mitochondrial biogenesis and that how PGC-1α SUMOylation is regulated. In this study, we have identified the role of Sentrin/SUMO-specific protease 1 (SENP1) as a specific SUMO protease to regulate SUMOylation status of PGC-1α. More importantly, we have also found that SENP1 promotes PGC-1α transcription activity, which is essential for the expression of mitochondrial genes and subsequently mitochondrial biogenesis. Thus, we reveal that the SUMOylation of PGC-1α controlled by SENP1 plays an important role in mitochondrial biogenesis and function.
- Published
- 2012