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Your search keyword '"Abu-Asab, Mones"' showing total 5 results
Start Over Author "Abu-Asab, Mones" Journal journal of biological chemistry
5 results on '"Abu-Asab, Mones"'

2. The Rho Guanine Nucleotide Exchange Factor AKAP13 (BRX) Is Essential for Cardiac Development in Mice

Author

Mayers, Chantal M., primary, Wadell, Jennifer, additional, McLean, Kate, additional, Venere, Monica, additional, Malik, Minnie, additional, Shibata, Takahisa, additional, Driggers, Paul H., additional, Kino, Tomoshige, additional, Guo, X.Catherine, additional, Koide, Hisashi, additional, Gorivodsky, Marat, additional, Grinberg, Alex, additional, Mukhopadhyay, Mahua, additional, Abu-Asab, Mones, additional, Westphal, Heiner, additional, and Segars, James H., additional

Published
2010
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3. Sialylated Core 1 O-Glycans Influence the Sorting of Pmel17/gp100 and Determine Its Capacity to Form Fibrils

Author

Valencia, Julio C., primary, Rouzaud, Francois, additional, Julien, Sylvain, additional, Chen, Kevin G., additional, Passeron, Thierry, additional, Yamaguchi, Yuji, additional, Abu-Asab, Mones, additional, Tsokos, Maria, additional, Costin, Gertrude E., additional, Yamaguchi, Hiroshi, additional, Jenkins, Lisa M. Miller, additional, Nagashima, Kunio, additional, Appella, Ettore, additional, and Hearing, Vincent J., additional

Published
2007
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4. Biophysical Characterization of gp41 Aggregates Suggests a Model for the Molecular Mechanism of HIV-associated Neurological Damage and Dementia

Author

Caffrey, Michael, primary, Braddock, Demetrios T., additional, Louis, John M., additional, Abu-Asab, Mones A., additional, Kingma, Douglas, additional, Liotta, Lance, additional, Tsokos, Maria, additional, Tresser, Nancy, additional, Pannell, Lewis K., additional, Watts, Norman, additional, Steven, Alasdair C., additional, Simon, Martha N., additional, Stahl, Stephen J., additional, Wingfield, Paul T., additional, and Clore, G.Marius, additional

Published
2000
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5. Myocilin Mediates Myelination in the Peripheral Nervous System through ErbB2/3 Signaling.

Author

Heung Sun Kwon, Johnson, Thomas V., Myung Kuk Joe, Abu-Asab, Mones, Jun Zhang, Chi Chao Chan, and Tomarev, Stanislav I.

Subjects
*MYOCILIN, *CYTOSKELETAL proteins, *GLAUCOMA, *SCHWANN cells, *PERIPHERAL nervous system, *MYELIN sheath, *GENETICS
Abstract

The glaucoma-associated gene, myocilin, is expressed in ocular and non-ocular tissues including the peripheral nervous system, but its functions in these tissues remain poorly understood. We demonstrate that in sciatic nerve, myocilin is expressed in Schwann cells with high concentrations at the nodes of Ranvier. There, myocilin interacts with gliomedin, neurofascin, and NrCAM, which are essential for node formation and function. Treatment of isolated dorsal root ganglion cultures with myocilin stimulates clustering of the nodal proteins neurofascin and sodium channel Nav1.2. Sciatic nerves of myocilin null mice express reduced levels of several myelin-associated and basal membrane proteins compared with those of wild-type littermates. They also demonstrate reduced myelin sheath thickness and partial disorganization of the nodes. Myocilin signaling through ErbB2/3 receptors may contribute to these observed effects. Myocilin binds to ErbB2/ErbB3, activates these receptors, and affects the downstream PI3K-AKT signaling pathway. These data implicate a role for myocilin in the development and/or maintenance of myelination and nodes of Ranvier in sciatic nerve. [ABSTRACT FROM AUTHOR]

Published
2013
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