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There are many controversies regarding Jue Yin disease in the Treatise on Febrile Diseases. The author found that it is reasonable to understand Jue Yin disease from two perspectives; a deficiency of bodily fluids, and the advance and retreat of Yin and Yang based on an understanding of Huangdi Neijing and modern scholars on Jue Yin disease, the meaning of the internal meridian, and the research result of modern medicine on Jue Yin disease. If Jue Yin disease is regarded as the state of Yin and Yang advancing and retreating based on deficiencies of bodily fluids, then article 326 and the Wumei pill can be regarded as the outline syndrome and main prescription of Jue Yin disease, respectively. The progression and withdrawal of Yin and Yang and the associated fluctuation of bodily fluids make Jue Yin disease dy-namic and multiphasic. The essence of Jue Yin disease is determined by the characteristics of bodily fluids and the Yang Qi. Instead of focusing on the disease location or the combination of cold and heat, whether the Yang Qi advances or retreats and the coordination of the bodily fluid state should be focused on as the internal cause of the transfer of Jue Yin disease to Yin and Yang, or the occurrence of heat, cold and the sell-healing syndrome. Although Yin and Yang are all-inclusive, the state of bodily fluids has many meanings; there is a significant deficiency of bodily fluids in Jue Yin disease. As such, by emphasizing the state of bodily fluids and the characteristics of Yin and Yang, Jue Yin disease can be better explained and gains a certain clinical significance. [ABSTRACT FROM AUTHOR]