1. No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children.
- Author
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Ahlfors SP, Graham S, Bharadwaj H, Mamashli F, Khan S, Joseph RM, Losh A, Pawlyszyn S, McGuiggan NM, Vangel M, Hämäläinen MS, and Kenet T
- Subjects
- Humans, Child, Male, Female, Adolescent, Autism Spectrum Disorder physiopathology, Magnetoencephalography methods, Acoustic Stimulation methods, Evoked Potentials, Auditory physiology, Auditory Perception physiology
- Abstract
Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6-17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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