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Start Over Author "Kirsch, Sarah" Journal journal of autism and developmental disorders
3 results on '"Kirsch, Sarah"'

3. Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder.

Author

Gadow KD, Roohi J, DeVincent CJ, Kirsch S, and Hatchwell E

Subjects
Adolescent, Alleles, Anxiety complications, Anxiety psychology, Child, Child Development Disorders, Pervasive complications, Child Development Disorders, Pervasive psychology, Child, Preschool, Female, Genotype, Humans, Male, Obsessive-Compulsive Disorder complications, Obsessive-Compulsive Disorder genetics, Obsessive-Compulsive Disorder psychology, Stereotypic Movement Disorder complications, Stereotypic Movement Disorder psychology, Anxiety genetics, Child Development Disorders, Pervasive genetics, Excitatory Amino Acid Transporter 3 genetics, Polymorphism, Single Nucleotide genetics, Stereotypic Movement Disorder genetics
Abstract

Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.

Published
2010
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