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Your search keyword '"Statistical significance"' showing total 2 results
2 results on '"Statistical significance"'

1. Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity.

Author

Salem, Sohair and Ashaat, Engy

Subjects
*STATISTICAL correlation, *PEARSON correlation (Statistics), *T-test (Statistics), *RECEIVER operating characteristic curves, *DATA analysis, *STATISTICAL significance, *RESEARCH funding, *AUTISM, *LOGISTIC regression analysis, *DNA, *SEVERITY of illness index, *DESCRIPTIVE statistics, *DNA methylation, *STATISTICS, *ANALYSIS of variance, *TELOMERES, *DATA analysis software, *BIOMARKERS
Abstract

Autism is associated with genomic instability, which is regulated by telomere length (TL) and index of global methylation (LINE-1). This study will determine relative TL (RTL) and LINE-1 methylation percentage for 69 patients and 33 control subjects to evaluate their potential role as biomarkers for autism. The results displayed a significant decrease of both RTL and LINE-1 methylation in autistic cases relative to controls (P < 0.001). Analysis of receiver operating characteristics curve revealed that both of RTL and LINE-1 methylation percentage have the ability to serve as autism biomarkers (area under the curve = 0.817 and 0.889, respectively). The statistical analysis revealed positive correlation between the two biomarkers (correlation coefficient = 0.439 and P < 0.001). [ABSTRACT FROM AUTHOR]

Published
2024
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2. Patterns of Sensitivity to Emotion in Children with Williams Syndrome and Autism: Relations Between Autonomic Nervous System Reactivity and Social Functioning.

Author

Järvinen, Anna, Ng, Rowena, Crivelli, Davide, Neumann, Dirk, Grichanik, Mark, Arnold, Andrew, Lai, Philip, Trauner, Doris, and Bellugi, Ursula

Subjects
*AUTONOMIC nervous system physiology, *ANALYSIS of covariance, *AROUSAL (Physiology), *AUTISM, *COGNITIVE testing, *COMPARATIVE studies, *STATISTICAL correlation, *ELECTROCARDIOGRAPHY, *EMOTIONS in children, *EXPERIMENTAL design, *FACIAL expression, *INTELLIGENCE tests, *SENSORY perception, *PSYCHOPHYSIOLOGY, *REACTION time, *RESEARCH funding, *SENSORY stimulation, *SOCIAL skills, *STATISTICAL hypothesis testing, *STATISTICS, *WILLIAMS syndrome, *SAMPLE size (Statistics), *DATA analysis, *SOCIAL attitudes, *STATISTICAL significance, *REPEATED measures design, *ONE-way analysis of variance, *SYMPTOMS, *CHILDREN
Abstract

Williams syndrome (WS) and autism spectrum disorder (ASD) are associated with atypical social-emotional functioning. Affective visual stimuli were used to assess autonomic reactivity and emotion identification, and the social responsiveness scale was used to determine the level social functioning in children with WS and ASD contrasted with typical development (TD), to examine syndrome-specific and syndrome-general features. Children with ASD exhibited the highest arousal in response to faces, with a lack of difference in autonomic sensitivity across different emotional expressions, unlike in WS and TD. The WS group demonstrated unique deficits in identifying neutral stimuli. While autonomic responsivity to neutral faces was associated with social functioning in all children, converging profiles characterized children with WS contrasted with TD and ASD. [ABSTRACT FROM AUTHOR]

Published
2015
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