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Your search keyword '"Ota, Atsuhiko"' showing total 4 results
Start Over Author "Ota, Atsuhiko" Journal journal of atherosclerosis and thrombosis
4 results on '"Ota, Atsuhiko"'

1. Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study

Author

Matsunaga, Masaaki, Yatsuya, Hiroshi, Iso, Hiroyasu, Li, Yuanying, Yamagishi, Kazumasa, Tanabe, Naohito, Wada, Yasuhiko, Ota, Atsuhiko, Tamakoshi, Koji, and Tamakoshi, Akiko

Subjects
Male, Biochemistry (medical), Overweight, Cardiovascular disease, Body Mass Index, Cohort Studies, Japan, Cardiovascular Diseases, Risk Factors, Neoplasms, Internal Medicine, Humans, Female, Obesity, Cardiology and Cardiovascular Medicine, Cancer
Abstract

Aim: We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians.Methods: We studied 102,535 participants aged 40-79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (= 27.5 kg/m2) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints.Results: During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25-27.4 and >= 27.5 kg/m2) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI >= 25 kg/m2 for obesity-related cancer was -0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women.Conclusion: A BMI >= 25 kg/m2 is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.

Published
2022

2. Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting

Author

Al-shoaibi, Abubakr Ahmed Abdullah, primary, Li, Yuanying, additional, Song, Zean, additional, Chiang, Chifa, additional, Hirakawa, Yoshihisa, additional, Saif-Ur-Rahman, KM, additional, Shimoda, Masako, additional, Nakano, Yoshihisa, additional, Matsunaga, Masaaki, additional, Aoyama, Atsuko, additional, Tamakoshi, Koji, additional, Ota, Atsuhiko, additional, and Yatsuya, Hiroshi, additional

Published
2022
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4. Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting.

Author

Al-Shoaibi AAA, Li Y, Song Z, Chiang C, Hirakawa Y, Saif-Ur-Rahman KM, Shimoda M, Nakano Y, Matsunaga M, Aoyama A, Tamakoshi K, Ota A, and Yatsuya H

Subjects
Adult, Female, Humans, Middle Aged, Cerebral Hemorrhage, Cholesterol, LDL, Cohort Studies, East Asian People, Follow-Up Studies, Prospective Studies, Risk Factors, Male, Coronary Disease epidemiology, Coronary Disease etiology, Ischemic Stroke, Stroke epidemiology, Stroke etiology
Abstract

Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers' Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes., Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD., Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160- mg/dL compared to LDL-C 100-119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91-10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44-2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009)., Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

Published
2023
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