1. Effect of omalizumab on bronchoalveolar lavage matrix metalloproteinases in severe allergic asthma
- Author
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Lech Zareba, Bogdan Jakiela, Krzysztof Sładek, Agnieszka Gawlewicz-Mroczka, Krzysztof Okoń, Jerzy Soja, Marek Przybyszowski, Weronika Zastrzeżyńska, Stanisława Bazan-Socha, Jacek Musiał, and Hanna Plutecka
- Subjects
Pulmonary and Respiratory Medicine ,Omalizumab ,Matrix metalloproteinase ,Extracellular matrix ,03 medical and health sciences ,0302 clinical medicine ,Hypersensitivity ,Humans ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,Asthma ,Bronchial wall ,medicine.diagnostic_test ,business.industry ,Airway inflammation ,Allergic asthma ,respiratory system ,medicine.disease ,Fibronectins ,respiratory tract diseases ,Bronchoalveolar lavage ,Matrix Metalloproteinase 9 ,030228 respiratory system ,Pediatrics, Perinatology and Child Health ,Immunology ,Airway Remodeling ,Collagen ,business ,Bronchoalveolar Lavage Fluid ,medicine.drug - Abstract
Airway inflammation in asthma is accompanied by reconstruction of the bronchial wall extracellular matrix that most likely occurs with a contribution of matrix metalloproteinases (MMPs). Recently we have reported that omalizumab may decrease reticular basement membrane (RBM) thickness together with fibronectin deposits in asthmatic airways, although mechanisms involved are unknown.In the present study, we have investigated the impact of omalizumab on MMPs concentrations in bronchoalveolar lavage fluid (BAL) of asthmatic subjects in relation to airway remodeling changes in histology.The study group consisted of 13 severe allergic asthmatics treated with omalizumab for at least 12 months. In each subject, clinical and laboratory parameters, bronchoscopy with BAL, and endobronchial biopsy were evaluated before and after the biologic therapy. RBM thickness, fibronectin, and collagen deposits in bronchial mucosa specimens were analyzed in histology. The investigations also included BAL cytology and BAL concentrations of MMP-2, -3, and -9.Omalizumab was related to a decrease in all measured MMPs in BAL (Our data suggest that omalizumab therapy is associated with decreased BAL MMPs concentration in the subgroup of asthma patients. The decline was linked with a reduction in the RBM thickness what might play a beneficial role in airway remodeling.
- Published
- 2021