1. Determinants of exercise capacity in children and adolescents with severe therapy-resistant asthma
- Author
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Cláudia Silva Schindel, Paulo Márcio Pitrez, Natália Evangelista Campos, Daniele Schiwe, Márcio Vinícius Fagundes Donadio, Mailise Fatima Gheller, and João Paulo Heinzmann-Filho
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Therapy resistant ,Exercise Tolerance ,Adolescent ,business.industry ,Exercise capacity ,medicine.disease ,Asthma ,03 medical and health sciences ,Cross-Sectional Studies ,0302 clinical medicine ,030228 respiratory system ,Forced Expiratory Volume ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Exercise Test ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Child ,business - Abstract
To evaluate the exercise capacity of children and adolescents with severe therapy resistant asthma (STRA) aiming to identify its main determinants.Cross-sectional study including individuals aged 6-18 years with a diagnosis of STRA. Clinical (age and gender), anthropometric (weight, height and body mass index) and disease control data were collected. Lung function (spirometry), cardiopulmonary exercise testing (CPET) and exercise-induced bronchoconstriction (EIB) test were performed.Twenty-four patients aged 11.5 ± 2.6 years were included. The mean forced expiratory volume in one second (FEVExercise capacity is impaired in approximately 30% of children and adolescents with STRA. The results indicate that different aspects of aerobic fitness are influenced by distinct determinants, including lung function and EIB.
- Published
- 2020