1. History of cancer and fertility treatment outcomes: a registry linkage study in Massachusetts.
- Author
-
Farland, Leslie V., Stern, Judy E., Hwang, Sunah S., Liu, Chia-ling, Cabral, Howard, Knowlton, Richard, Gershman, Susan T., Coddington III, Charles C., and Missmer, Stacey A.
- Subjects
TREATMENT effectiveness ,INDUCED ovulation ,GENERALIZED estimating equations ,REPRODUCTIVE technology ,MISCARRIAGE ,HUMAN in vitro fertilization - Abstract
Purpose: To investigate assisted reproductive technology (ART) outcomes among adolescent and young-adult female cancer survivors. Methods: The Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) data were linked to the Massachusetts Cancer Registry for 90,928 ART cycles in Massachusetts to women ≥ 18 years old from 2004 to 2013. To estimate relative risks (RR) and 95% confidence intervals (CI), we used generalized estimating equations with a log link that accounted for multiple cycles per woman and a priori adjusted for maternal age and cycle year. The main outcomes of interest were ART treatment patterns; number of autologous oocytes retrieved, fertilized, and transferred; and rates of implantation, clinical intrauterine gestation (CIG), live birth, and pregnancy loss. Results: We saw no difference in number of oocytes retrieved (aRR: 0.95 (0.89–1.02)) or proportion of autologous oocytes fertilized (aRR: 0.99 (0.95–1.03)) between autologous cycles with and without a history of cancer; however, cancer survivors required a higher total FSH administered (aRR: 1.12 (1.06–1.19)). Among autologous cycle starts, cycles in women with a history of cancer were less likely to result in CIG compared to no history of cancer (aRR: 0.73 (0.65–0.83)); this relationship was absent from donor cycles (aRR: 1.01 (0.85–1.20)). Once achieving CIG, donor cycles for women with a history of cancer were two times more likely to result in pregnancy loss (aRR: 1.99 (1.26–3.16)). Conclusions: Our analysis suggests that cancer may influence ovarian stimulation response, requiring more FSH and resulting in lower CIG among cycle starts. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF