1. Bioactive amides from Polygonum cuspidatum
- Author
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Zi-Ming Feng, Jian-Shuang Jiang, Fu Liu, Ya-Nan Yang, Xu Zhang, and Pei-Cheng Zhang
- Subjects
Pharmacology ,biology ,010405 organic chemistry ,Stereochemistry ,Chemistry ,Organic Chemistry ,Pharmaceutical Science ,General Medicine ,biology.organism_classification ,01 natural sciences ,Nmr data ,Polygonaceae ,0104 chemical sciences ,Analytical Chemistry ,Rhizome ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Drug Discovery ,Molecular Medicine ,Enantiomer ,POLYGONUM CUSPIDATUM - Abstract
One pair of new amides enantiomers (1a and 1b) and two known amides were isolated from the rhizomes of Polygonum cuspidatum. Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations were determined by the ECD method. All compounds were evaluated for their α-glucosidase inhibitory activity and compounds 2 and 3 showed significant inhibitory activity with IC50 values of 2.82 and 13.06 μmol/L, respectively (positive control acarbose, IC50 385 μmol/L).
- Published
- 2021