1. Antimalarial and cytotoxic quassinoids from the roots of Brucea javanica.
- Author
-
Chumkaew P and Srisawat T
- Subjects
- Animals, Antimalarials chemistry, Humans, Inhibitory Concentration 50, Molecular Structure, Quassins chemistry, Antimalarials isolation & purification, Antimalarials pharmacology, Brucea chemistry, Plant Roots chemistry, Plasmodium falciparum drug effects, Quassins isolation & purification, Quassins pharmacology
- Abstract
Two new quassinoids, brujavanol A (1) and brujavanol B (2), along with five known quassinoids (3-7), were isolated from the roots of Brucea javanica. Their structures were elucidated by spectroscopic methods. The antimalarial and cytotoxic activities of the isolated compounds were also assessed. Compounds 1 and 2 exhibited significant in vitro cytotoxicity against human oral cavity cancer (KB) cells with IC
50 values of 1.30 and 2.36 μg/ml, respectively, whereas compound 3 showed excellent antiplasmodial activity against the Plasmodium falciparum strains, K1 (IC50 = 0.58 μg/ml).- Published
- 2017
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