1. Three new dammarane-type triterpene saponins from the leaves ofPanax ginsengC.A. Meyer
- Author
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Hongyu Zhou, Yongri Jin, Wei Wei, Xuwen Li, Bin Yang, Ming-Yu Gui, Nian-Bin Wang, and Guiying Liu
- Subjects
Ginsenosides ,Stereochemistry ,Saponin ,Panax ,Pharmaceutical Science ,Pharmacognosy ,Analytical Chemistry ,Ginseng ,chemistry.chemical_compound ,Triterpene ,Drug Discovery ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,Traditional medicine ,biology ,Organic Chemistry ,Dammarane ,Glycoside ,Stereoisomerism ,General Medicine ,Saponins ,biology.organism_classification ,Triterpenes ,Plant Leaves ,Complementary and alternative medicine ,chemistry ,Ginsenoside ,Molecular Medicine ,Araliaceae ,Drugs, Chinese Herbal - Abstract
Three new dammarane-type triterpene ginsenosides, together with six known ginsenosides, were isolated from the leaves of Panax ginseng C.A. Meyer. The new saponins were named as ginsenoside Rh₁₁, ginsenoside Rh₁₂, and ginsenoside Rh₁₃. Their structures were elucidated as (20S)-3β,6α,12β,20-tetrahydroxydammara-25-ene-24-one 20-O-β-d-glucopyranoside (1), (20S)-3β,12β,20,24,25-pentahydroxydammarane 20-O-β-d-glucopyranoside (2), and (20S,23E)-3β,12β,20,25-tetrahydroxydammara-23-ene 20-O-β-d-glucopyranoside (3) on the basis of 1D and 2D NMR experiments and mass spectra. The known ginsenosides were identified as ginsenoside M(₇cd), ginsenoside Rg₆, ginsenoside Rb₃, gypenoside XVII, gypenoside IX, and 20-(E)-ginsenoside F₄.
- Published
- 2010
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