1. Two new 12-membered macrolides from the endophytic fungal strain Cladosprium colocasiae A801 of Callistemon viminalis
- Author
-
Haibo Tan, Sheng-Xiang Qiu, Yuchan Chen, Hongxin Liu, Hao-Hua Li, Weimin Zhang, and Saini Li
- Subjects
Pharmacology ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Pharmaceutical Science ,General Medicine ,Endophytic fungus ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Polyketide ,Complementary and alternative medicine ,Callistemon viminalis ,Chemical constituents ,Drug Discovery ,Botany ,Molecular Medicine ,Fungal strain - Abstract
Two new polyketide metabolites, the 12-membered macrolides 4-hydroxy-12-methyloxacyclododecane-2,5,6-trione (1) and 12-methyloxacyclododecane-2,5,6-trione (2), were isolated from the endophytic fungal strain Cladosprium colocasiae A801 of the plant Callistemon viminalis, together with five known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. The antibacterial, cytotoxic, and α-glucosidase inhibitory activities of the new compounds 1 and 2 were evaluated.
- Published
- 2018