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Three new benzolactones (1–3), together with four known ones (4–7), were isolated from the whole herb ofLavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New compounds were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxic activities. The results revealed that compounds1–3showed obvious anti-TMV activities with inhibition rates of 26.9, 30.2, and 28.4%, which were at the same grade as positive control. Compounds1–3also showed weak inhibitory activities against some tested human tumor cell lines with IC50values in the range of 32.1–7.6 μM. [ABSTRACT FROM PUBLISHER]