1. Cytotoxic triterpenoid saponins from the defatted seeds of Camellia oleifera Abel.
- Author
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Fu, Hui-Zheng, Wan, Kai-Hua, Yan, Qing-Wei, Zhou, Guo-Ping, Feng, Tong-Tong, Dai, Mian, and Zhong, Rui-Jian
- Subjects
ALTERNATIVE medicine ,ANTINEOPLASTIC agents ,BIOLOGICAL assay ,BIOLOGICAL models ,PHYSICAL & theoretical chemistry ,COLON tumors ,DOSE-effect relationship in pharmacology ,HEPATOCELLULAR carcinoma ,HIGH performance liquid chromatography ,LUNG tumors ,MEDICINAL plants ,NUCLEAR magnetic resonance spectroscopy ,OVARIAN tumors ,PROBABILITY theory ,RESEARCH funding ,SEEDS ,STOMACH tumors ,PLANT extracts ,DESCRIPTIVE statistics ,IN vitro studies ,PHARMACODYNAMICS - Abstract
Five new oleanane-type triterpenoid saponins, oleiferasaponins D
1 -D5 (1-5), were isolated from the defatted seeds of Camellia oleifera Abel. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of compounds 1-5 were evaluated against five human tumor cell lines (HCT-116, HepG2, BGC-823, NCI-H1650, and A2780). Compounds 1-2 exhibited cytotoxic activity against five human cancer cell lines, with IC50 values ranging from 3.31 to 10.23 μM. Compounds 3-5 showed moderate cytotoxic activities toward the tested cell lines. [ABSTRACT FROM AUTHOR]- Published
- 2018
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