1. Two triterpenoid glycosides from the roots of Camellia oleifera and their cytotoxic activity.
- Author
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Yang, Ping, Li, Xia, Liu, Yan-Li, Xu, Qiong-Ming, Li, Yun-Qiu, and Yang, Shi-Lin
- Subjects
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ANIMAL experimentation , *ANTINEOPLASTIC agents , *BIOLOGICAL assay , *CELL culture , *CELL lines , *CHROMATOGRAPHIC analysis , *GLYCOSIDES , *INFRARED spectroscopy , *MASS spectrometry , *MICE , *NUCLEAR magnetic resonance spectroscopy , *RESEARCH funding , *PLANT roots , *TERPENES , *TOXICITY testing , *DESCRIPTIVE statistics , *IN vitro studies - Abstract
Two new triterpenoid saponins, oleiferoside N and oleiferoside O, were isolated from the EtOH extract from the roots ofCamellia oleiferaC. Abel. Their structures were elucidated as 16α-acetoxy-21β,22α-O-diangeloyloxy-23,28-dihydroxyolean-12-ene 3β-O-β-d-xylopyranosyl-(1 → 3)-α-l-arabinopyranosyl-(1 → 3)-β-d-glucuronopyranoside (1), 16α-acetoxy-21β-O-angeloyloxy-23,28-dihydroxy-22α-O-(2-methylbutanoyloxy)olean-12-ene 3β-O-β-d-xylopyranosyl-(1 → 3)-α-l-arabinopyranosyl-(1 → 3)-β-d-glucuronopyranoside (2), on the basis of spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR) and acid hydrolysis. Both were characterized to be oleanane-type saponins with sugar moieties linked to C-3 of the aglycone. Cytotoxic activities of two saponins were evaluated against four human tumor cell lines (A549, B16, BEL-7402, and MCF-7) by using the MTTin vitroassay. Compounds1and2showed moderate cytotoxic activities toward the tested cell lines. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
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