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Your search keyword '"Liu, Yan"' showing total 3 results
3 results on '"Liu, Yan"'

1. Two new iridoid glycosides from the whole plant of Rehmania piasezkii.

Author

Zhou, Jie, Shi, Guo-Ru, Zhang, Wan-Qi, Yu, De-Quan, and Liu, Yan-Fei

Subjects
CHINESE medicine, RESEARCH funding, NUCLEAR magnetic resonance spectroscopy, HERBAL medicine, SPECTROPHOTOMETERS, THIN layer chromatography, DESCRIPTIVE statistics, PLANT extracts, CELL lines, MEDICINAL plants, GLYCOSIDES, MOLECULAR structure, BIOLOGICAL assay, HEPATOCELLULAR carcinoma, ACETAMINOPHEN
Abstract

Two new iridoid glycosides, piasezkiiosides A (1) and B (2), were isolated from aqueous extract of the whole plant of Rehmannia piasezkii. Their structures were established from the spectroscopic data, chemical transformation, and X-ray diffraction analysis. Compound 1 exhibited weak hepatoprotective activity against APAP-induced HepG2 cell damage. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice.

Author

Chen, Zi-Han, Liu, Yan-Xin, Chen, Zhi-Wei, Lin, Mo-Di, Zhang, Jin-Lan, Wang, Zhe, and Sun, Hua

Subjects
*MYOCARDIAL infarction, *BIOLOGICAL models, *IN vitro studies, *MITOCHONDRIA, *T-test (Statistics), *STATISTICAL significance, *RESEARCH funding, *APOPTOSIS, *OXIDATIVE stress, *PEPTIDE hormones, *IN vivo studies, *DESCRIPTIVE statistics, *ISOPROTERENOL, *CELL lines, *MICE, *REACTIVE oxygen species, *HYPERTROPHY, *CREATINE kinase, *ISOENZYMES, *CALCIUM, *ENERGY metabolism, *MEDICINAL plants, *ANIMAL experimentation, *MOLECULAR structure, *MYOCARDIUM, *ATRIAL natriuretic peptides, *ONE-way analysis of variance, *DATA analysis software, *HEART cells
Abstract

We established myocardial injury models in vivo and in vitro to investigate the cardioprotective effect of gomisin D obtained from Schisandra chinensis. Gomisin D significantly inhibited isoproterenol-induced apoptosis and hypertrophy in H9C2 cells. Gomisin D decreased serum BNP, ANP, CK-MB, cTn-T levels and histopathological alterations, and inhibited myocardial hypertrophy in mice. In mechanisms research, gomisin D reversed ISO-induced accumulation of intracellular ROS and Ca2+. Gomisin D further improved mitochondrial energy metabolism disorders by regulating the TCA cycle. These results demonstrated that gomisin D had a significant effect on isoproterenol-induced myocardial injury by inhibiting oxidative stress, calcium overload and improving mitochondrial energy metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Four new iridoid glycosides from the roots of Rehmannia glutinosa.

Author

Liu, Yan-Fei, Zhang, Wan-Qi, Zhou, Jie, Shi, Guo-Ru, Li, Xin-Yue, Sun, Ming-Hui, Chen, Ruo-Yun, and Yu, De-Quan

Subjects
*CHINESE medicine, *RESEARCH funding, *CELL proliferation, *HEXOSES, *PLANT roots, *DESCRIPTIVE statistics, *PLANT extracts, *CELL lines, *GLYCOSIDES, *MEDICINAL plants, *MOLECULAR structure, *LACTOBACILLUS
Abstract

Four new iridoid glycosides (1–4), rehmaglutosides L–O, were isolated from the air-dried roots of Rehmannia glutinosa. Their structures were established from the spectroscopic data obtained and by chemical evidence. The known mellittoside (5) and ajugol (6) were also obtained in the current investigation, and the structure of mellittoside was unequivocally defined using X-ray diffraction data. Compounds 1–6 were tested for their cytotoxicity against five human tumor cell lines and proliferation effects on Lactobacillus Reuteri. [ABSTRACT FROM AUTHOR]

Published
2024
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