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Start Over Author "Najvar LK" Journal journal of antimicrobial chemotherapy (jac)
2 results on '"Najvar LK"'

2. SCH56592 treatment of murine invasive aspergillosis.

Author

Graybill, JR, Bocanegra, R, Najvar, LK, Luthe, MF, Loebenberg, D, Graybill, J R, Najvar, L K, and Luther, M F

Abstract

Mice were immunosuppressed using corticosteroids and infected with conidia of Aspergillus fumigatus. Beginning 1 day after injection, mice were treated orally either with Noble agar or with SCH56592 suspended in Noble agar, or intraperitoneally with amphotericin B. SCH56592 prolonged survival and reduced lung tissue counts of A. fumigatus, while amphotericin B had marginal benefit. SCH56592 merits further development for treatment of aspergillosis. [ABSTRACT FROM PUBLISHER]

Published
1998
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