1. Antiretroviral resistance at virological failure in the NEAT 001/ANRS 143 trial: raltegravir plus darunavir/ritonavir or tenofovir/emtricitabine plus darunavir/ritonavir as first-line ART
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Lambert Niclot, S, George, E. C., Pozniak, A., White, E., Schwimmer, C., Jessen, H., Johnson, M., Dunn, D., Perno, C. F., Clotet, B., Plettenberg, A., Blaxhult, A., Palmisano, L., Wittkop, L., Calvez, V., Marcelin, A. G., Raffi, F., Dedes, Nikos, Chěne, Geneviève, Allavena, Clotilde, Autran, Brigitte, Antinori, Andrea, Bucciardini, Raffaella, Vella, Stefano, Horban, Andrzej, Arribas, Jose, Babiker, Abdel G., Boffito, Marta, Pillay, Deenan, Pozniak, Anton, Franquet, Xavier, Schwarze, Siegfried, Grarup, Jesper, Fischer, Aurélie, Richert, Laura, Wallet, Cédrick, Raffi, François, Diallo, Alpha, Molina, Jean Michel, Saillard, Juliette, Moecklinghoff, Christiane, Stellbrink, Hans Jürgen, Van Leeuwen, Remko, Gatell, Jose, Sandstrom, Eric, Flepp, Markus, Ewings, Fiona, George, Elizabeth C., Hudson, Fleur, Pearce, Gillian, Quercia, Romina, Rogatto, Felipe, Leavitt, Randi, Nguyen, Bach Yen, Goebel, Frank, Marcotullio, Simone, Kaur, Navrup, Sasieni, Peter, Spencer Drake, Christina, Peto, Tim, Miller, Veronica, Arnault, Fabien, Boucherie, Céline, Jean, Delphine, Paniego, Virginie, Paraina, Felasoa, Rouch, Elodie, Schwimmer, Christine, Soussi, Malika, Taieb, Audrey, Termote, Monique, Touzeau, Guillaume, Cursley, Adam, Dodds, Wendy, Hoppe, Anne, Kummeling, Ischa, Pacciarini, Filippo, Paton, Nick, Russell, Charlotte, Taylor, Kay, Ward, Denise, Aagaard, Bitten, Eid, Marius, Gey, Daniela, Jensen, Birgitte Gram, Jakobsen, Marie Louise, Jansson, Per O., Jensen, Karoline, Joensen, Zillah Maria, Larsen, Ellen Moseholm, Pahl, Christiane, Pearson, Mary, Nielsen, Birgit Riis, Reilev, Søren Stentoft, Christ, Ilse, Lathouwers, Desiree, Manting, Corry, Mendy, Bienvenu Yves, Metro, Annie, Couffin Cadiergues, Sandrine, Knellwolf, Anne Laure, Palmisiano, Lucia, Aznar, Esther, Barea, Cristina, Cotarelo, Manuel, Esteban, Herminia, Girbau, Iciar, Moyano, Beatriz, Ramirez, Miriam, Saiz, Carmen, Sanchez, Isabel, Yllescas, Maria, Binelli, Andrea, Colasanti, Valentina, Massella, Maurizio, Anagnostou, Olga, Gioukari, Vicky, Touloumi, Giota, Schmied, Brigitte, Rieger, Armin, Vetter, Norbert, De Wit, Stephane, Florence, Eric, Vandekerckhove, Linos, Gerstoft, Jan, Mathiesen, Lars, Katlama, Christine, Cabie, Andre, Cheret, Antoine, Dupon, Michel, Ghosn, Jade, Girard, Pierre Marie, Goujard, Cécile, Lévy, Yves, Morlat, Philippe, Neau, Didier, Obadia, Martine, Perre, Philippe, Reynes, Jacques, Tattevin, Pierre, Ragnaud, Jean Marie, Weiss, Laurence, Yazdan, Yazdanpanah, Yeni, Patrick, Zucman, David, Behrens, Georg, Esser, Stefan, Fätkenheuer, Gerd, Hoffmann, Christian, Jessen, Heiko, Rockstroh, Jürgen, Schmidt, Reinhold, Stephan, Christoph, Unger, Stefan, Hatzakis, Angelos, Daikos, George L., Papadopoulos, Antonios, Skoutelis, Athamasios, Banhegyi, Denes, Mallon, Paddy, Mulcahy, Fiona, Andreoni, Massimo, Bonora, Stefano, Castelli, Francesco, Monforte, Antonella D'Arminio, DI PERRI, Giovanni, Galli, Massimo, Lazzarin, Adriano, Mazzotta, Francesco, Carlo, Torti, Vullo, Vincenzo, Prins, Jan, Richter, Clemens, Verhagen, Dominique, Van Eeden, Arne, Doroana, Manuela, Antunes, Francisco, Maltez, Fernando, Sarmento Castro, Rui, Garcia, Juan Gonzalez, Aldeguer, José López, Clotet, Bonaventura, Domingo, Pere, Gatell, Jose M., Knobel, Hernando, Marquez, Manuel, Miralles, Martin Pilar, Portilla, Joaquin, Soriano, Vicente, Tellez, Maria Jesus, Thalme, Anders, Blaxhult, Anders, Gisslen, Magnus, Winston, Alan, Fox, Julie, Gompels, Mark, Herieka, Elbushra, Johnson, Margaret, Leen, Clifford, Teague, Alastair, Williams, Ian, Boyd, Mark Alastair, Møller, Nina Friis, Larsen, Ellen Frøsig Moseholm, Piroth, Lionel, Le Moing, Vincent, Wit, Ferdinand W. N. M., Kowalska, Justyna, Berenguer, Juan, Moreno, Santiago, Müller, Nicolas J., Török, Estée, Post, Frank, Angus, Brian, Calvez, Vincent, Boucher, Charles, Collins, Simon, Dunn, David, Lambert, Sidonie, Marcelin, Anne Geneviève, Perno, Carlo Federico, White, Ellen, Ammassari, Adriana, Stoehr, Wolgang, Schmidt, Reinhold Ernst, Odermarsky, Michal, Smith, Colette, Thiébaut, Rodolphe, De La Serna, Jose Ignacio Bernardino, Castagna, Antonella, Furrer, Hans Jackob, Mocroft, Amanda, Reiss, Peter, Fragola, Vincenzo, Lauriola, Marco, Murri, Rita, Nieuwkerk, Pythia, Spire, Bruno, Volny Anne, Alain, West, Brian, Amieva, Hélène, Codina, Josep Maria Llibre, Braggion, Marco, Focá, Emanuele, Lambert-Niclot, S., George, E. C., Pozniak, A., White, E., Schwimmer, C., Jessen, H., Johnson, M., Dunn, D., Perno, C. F., Clotet, B., Plettenberg, A., Blaxhult, A., Palmisano, L., Wittkop, L., Calvez, V., Marcelin, A. G., Raffi, F., on behalf of NEAT 001/ANRS 143 Study, Group, Castagna, A, Global Health, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam Public Health, and Medical Psychology
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Male ,0301 basic medicine ,Adult ,Anti-HIV Agents ,CD4 Lymphocyte Count ,Female ,Follow-Up Studies ,HIV Infections ,HIV-1 ,Humans ,Microbial Sensitivity Tests ,Middle Aged ,Mutation ,Treatment Failure ,Treatment Outcome ,Antiretroviral Therapy, Highly Active ,Drug Resistance, Viral ,Viral Load ,Drug Resistance ,Gene mutation ,0302 clinical medicine ,1108 Medical Microbiology ,Medicine ,HIV Infection ,Pharmacology (medical) ,Viral ,030212 general & internal medicine ,Microbial Sensitivity Test ,Proteolytic enzymes ,virus diseases ,Settore MED/07 - Microbiologia e Microbiologia Clinica ,Infectious Diseases ,Viral load ,0605 Microbiology ,Human ,medicine.drug ,Microbiology (medical) ,030106 microbiology ,Antiretroviral Therapy ,Emtricitabine ,Microbiology ,Follow-Up Studie ,NEAT 001/ANRS 143 Study Group ,03 medical and health sciences ,Highly Active ,Darunavir ,Pharmacology ,business.industry ,Anti-HIV Agent ,Raltegravir ,Virology ,Regimen ,1115 Pharmacology And Pharmaceutical Sciences ,Ritonavir ,business - Abstract
Objectives: To describe the pattern of drug resistance at virological failure in the NEAT001/ANRS143 trial (first-line treatment with ritonavir-boosted darunavir plus either tenofovir/emtricitabine or raltegravir). Methods: Genotypic testing was performed at baseline for reverse transcriptase (RT) and protease genes and for RT, protease and integrase (IN) genes for patients with a confirmed viral load (VL) >50 copies/mL or any single VL >500 copies/mL during or after week 32. Results: A resistance test was obtained for 110/805 (13.7%) randomized participants qualifying for resistance analysis (61/401 of participants in the raltegravir arm and 49/404 of participants in the tenofovir/emtricitabine arm). No resistance-associated mutation (RAM) was observed in the tenofovir/emtricitabine plus darunavir/ritonavir arm, and all further analyses were limited to the raltegravir plus darunavir arm. In this group, 15/55 (27.3%) participants had viruses with IN RAMs (12 N155H alone, 1 N155H + Q148R, 1 F121Y and 1 Y143C), 2/53 (3.8%) with nucleotide analogue RT inhibitor RAMs (K65R, M41L) and 1/57 (1.8%) with primary protease RAM (L76V). The frequency of IN mutations at failure was significantly associated with baseline VL: 7.1% for a VL of
- Published
- 2016
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