1. Chemical modification of fortimicin A.
- Author
-
Suami T, Tadano K, and Matsuzawa K
- Subjects
- Aminoglycosides pharmacology, Bacteria drug effects, Chemical Phenomena, Chemistry, Drug Resistance, Microbial, Molecular Conformation, Structure-Activity Relationship, Anti-Bacterial Agents
- Abstract
Chlorination of antibiotic fortimicin A with triphenylphosphine and carbon tetrachloride has been attempted, and 2-chloro-, 2,5-dichloro-, and 2-chloro-4-ene derivatives have been obtained. Successive dehalogenation of the chlorinated fortimicins A with tributylstannane gave the corresponding deoxyfortimicins A. Among five deoxyfortimicins A, 2-deoxyfortimicin A exhibits improved antimicrobial activity, compared to the parent fortimicin A.
- Published
- 1980
- Full Text
- View/download PDF