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Your search keyword '"Reden J"' showing total 4 results
Start Over Author "Reden J" Journal journal of antibiotics
4 results on '"Reden J"'

1. Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series.

Author

Blumbach J, Dürckheimer W, Ehlers E, Fleischmann K, Klesel N, Limbert M, Mencke B, Reden J, Scheunemann KH, and Schrinner E

Subjects
Animals, Bacteria drug effects, Cefotaxime chemical synthesis, Cefotaxime metabolism, Cefotaxime pharmacology, Dogs, Half-Life, Indicators and Reagents, Kinetics, Mice, Microbial Sensitivity Tests, Structure-Activity Relationship, Cefotaxime analogs & derivatives
Abstract

The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs.

Published
1987
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3. Stereochemistry of the epoxydon group antibiotic G7063-2 isolated from a Streptomyces species HPL Y-25711.

Author

Reddy GC, Sood RS, Nadkarni SR, Reden J, Ganguli BN, Fehlhaber HW, and Snatzke G

Subjects
Molecular Conformation, Quinones, Anti-Bacterial Agents, Streptomyces metabolism
Abstract

The absolute configuration of the ring system of the antibiotic G7063-2 has been established as being the same as that reported for terreic acid, based on circular dichroism data. During structure elucidation experiments, reaction with ethereal diazomethane gave an adduct whose structure is proposed.

Published
1984
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