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Author(s): Victoria A. Eley [sup.1] [sup.2] [sup.4], Louis Guy [sup.1] [sup.2], Christine Woods [sup.1], Stacey Llewellyn [sup.3], Andre A. J. Van Zundert [sup.1] [sup.2] Author Affiliations: (1) https://ror.org/05p52kj31, grid.416100.2, 0000 [...], Transcutaneous carbon dioxide measurement (TcCO.sub.2) offers the ability to continuously and non-invasively monitor carbon dioxide (CO.sub.2) tensions when end-tidal monitoring is not possible. The accuracy of TcCO.sub.2 has not been established in anesthetized apneic patients with obesity. In this secondary publication, we present a methods comparison analysis of TcCO.sub.2 with the gold standard arterial PCO.sub.2, in adult patients with body mass index (BMI) > 35kg/m.sup.2 who were randomized to receive high flow or low flow nasal oxygenation during post-induction apnea. Agreement between PaCO.sub.2 and TcCO.sub.2 at baseline, the start of apnea and the end of apnea were assessed using a non-parametric difference plot. Forty-two participants had a median (IQR) BMI of 52 (40-58.5) kg/m.sup.2. The mean (SD) PaCO.sub.2 was 33.9 (4.0) mmHg at baseline and 51.4 (7.5) mmHg at the end of apnea. The bias was the greatest at the end of apnea median (95% CI, 95% limits of agreement) 1.90 mmHg (-2.64 to 6.44, -7.10 to 22.90). Findings did not suggest significant systematic differences between the PaCO.sub.2 and TcCO.sub.2 measures. For a short period of apnea, TcCO.sub.2 showed inadequate agreement with PaCO.sub.2 in patients with BMI > 35 kg/m.sup.2. These techniques require comparison in a larger population, with more frequent sampling and over a longer timeframe, before TcCO.sub.2 can be confidently recommended in this setting.

Transcutaneous carbon dioxide measurement (TcCO2) offers the ability to continuously and non-invasively monitor carbon dioxide (CO2) tensions when end-tidal monitoring is not possible. The accuracy of TcCO2 has not been established in anesthetized apneic patients with obesity. In this secondary publication, we present a methods comparison analysis of TcCO2 with the gold standard arterial PCO2, in adult patients with body mass index (BMI) > 35kg/m2 who were randomized to receive high flow or low flow nasal oxygenation during post-induction apnea. Agreement between PaCO2 and TcCO2 at baseline, the start of apnea and the end of apnea were assessed using a non-parametric difference plot. Forty-two participants had a median (IQR) BMI of 52 (40–58.5) kg/m2. The mean (SD) PaCO2 was 33.9 (4.0) mmHg at baseline and 51.4 (7.5) mmHg at the end of apnea. The bias was the greatest at the end of apnea median (95% CI, 95% limits of agreement) 1.90 mmHg (−2.64 to 6.44, −7.10 to 22.90). Findings did not suggest significant systematic differences between the PaCO2 and TcCO2 measures. For a short period of apnea, TcCO2 showed inadequate agreement with PaCO2 in patients with BMI > 35 kg/m2. These techniques require comparison in a larger population, with more frequent sampling and over a longer timeframe, before TcCO2 can be confidently recommended in this setting. [ABSTRACT FROM AUTHOR]