1. Comparison between in vivo and in vitro pharmacokinetics of succinylcholine in humans
- Author
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Takaaki Shiratori, Makoto Yamamuro, Yasuhiko Hashimoto, Shu Matsukawa, Shinobu Haga, Izadi Mobarakeh Jalal, Masato Kato, and Kunihiko Hoshi
- Subjects
medicine.medical_specialty ,biology ,business.industry ,organic chemicals ,Pain medicine ,Pharmacology ,In vitro ,carbohydrates (lipids) ,Anesthesiology and Pain Medicine ,nervous system ,Pharmacokinetics ,In vivo ,Anesthesia ,Anesthesiology ,polycyclic compounds ,biology.protein ,Medicine ,heterocyclic compounds ,business ,Cholinesterase - Abstract
To compare the in vivo and in vitro pharmacokinetics of succinylcholine (SCh) in humans.A bolus of SCh 1 mg.kg(-1) (n = 7) or 2 mg.kg(-1) (n = 11) was given to 18 patients anesthetized with thiopental. Arterial blood samples for determination of in vivo SCh concentrations were collected every 30 s for 5 min. Another 20-ml blood sample was obtained before induction of anesthesia for determination of in vitro SCh. Concentrations of SCh were measured by high-performance liquid chromatography. In vivo and in vitro concentrations of SCh vs time data were analyzed by the one-compartment model.The respective in vivo and in vitro pharmacokinetic parameters (SCh 1 mg.kg(-1) vs SCh 2 mg.kg(-1)) were as follows: Plasma clearance was 4.17 +/- 2.37 and 1.85 +/- 0.28 l.min(-1), P0.05, vs 2.91 +/- 2.01 and 1.27 +/- 0.43 l.min(-1), P0.05. Elimination half-life was 25.4 +/- 10.6 and 47.4 +/- 5.4 s, P0.002 vs 26.3 +/- 10.0 and 75.2 +/- 21.8 s, P0.00005.These results suggest that the rapid disappearance of SCh from the circulation is due to diffusion out of the blood vessels rather than to enzymatic hydrolysis.
- Published
- 1999
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