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Purpose There are no sufficient evidences for the sedative effect of gabapentin during anesthesia, especially intravenous sedation (IVS). The purpose of this study was to evaluate the sedative effect of gabapentin as preanesthetic medication during the IVS with propofol. Methods 10 volunteer subjects joined this study. They underwent propofol IVS three times on separate days. On the first day, the IVS without gabapentin was performed as a control. On the second and the third day, gabapentin 200 mg and 400 mg were administered before the IVS, respectively. The target blood concentration (C.sub.T) of propofol was gradually increased, and the bispectral index (BIS) value and Ramsay sedation score (RSS) were evaluated at each propofol C.sub.T. Postanesthetic complications and influences on vital signs were also evaluated. Results Compared to the control group, the propofol C.sub.Ts in the gabapentin 400 mg group significantly reduced at the BIS values of 60 and 70 (p = 0.031 and p = 0.043, respectively), and at RSS 3, 4, 5 and 6 (p = 0.040, p = 0.004, p = 0.001 and p = 0.004, respectively). There was no significant difference in propofol C.sub.Ts between the control group and the gabapentin 200 mg group. There were no abnormality and no deterioration in circulation and respiration in all groups. There were no significant increases in complications with the administration of gabapentin. Conclusion The oral administration of 400 mg dose of gabapentin reduced the propofol C.sub.Ts for achieving an adequate sedation level on IVS., Author(s): Rumiko Hosokawa [sup.1] , Shinichi Ito [sup.1] , Jun Hirokawa [sup.1] , Yu Oshima [sup.1] , Takeshi Yokoyama [sup.1] Author Affiliations: (Aff1) 0000 0001 2242 4849, grid.177174.3, Department of [...]

Purpose The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respiration, and postanesthetic complications. Methods Ten healthy young volunteers underwent 1 h of IVS using propofol, three times per subject, on separate days (first time, no pregabalin; second time, pregabalin 100 mg; third time, pregabalin 200 mg). The target blood concentration (C.sub.T) of propofol was increased in a stepwise fashion based on the bispectral index (BIS) value. Ramsay's sedation score (RSS) was determined at each propofol C.sub.T. Propofol C.sub.T was analyzed at each sedation level. Circulation and respiration during IVS and complications were also verified. Results Propofol C.sub.T was reduced at BIS values of 60 and 70 in both premedicated groups (100 mg: p = 0.043 and 0.041; 200 mg: p = 0.004 and 0.016, respectively) and at a BIS value of 80 in the pregabalin 200 mg group (p < 0.001). Propofol C.sub.T was decreased at RSS 4-6 in the pregabalin 100 mg group (RSS 4: p = 0.047; RSS 5: p = 0.007; RSS 6: p = 0.014), and at RSS 3-6 in the pregabalin 200 mg group (RSS 3-5: p < 0.001; RSS 6: p = 0.002). Conclusion We conclude that oral premedication with pregabalin reduces the amount of propofol required to obtain an acceptable and adequate sedation level., Author(s): Noriko Karube [sup.1] , Shinichi Ito [sup.1] , Saori Sako [sup.1] , Jun Hirokawa [sup.1] , Takeshi Yokoyama [sup.1] Author Affiliations: (1) Department of Dental Anesthesiology, Faculty of Dental [...]