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Your search keyword '"Matheux A"' showing total 3 results
Start Over Author "Matheux A" Journal journal of analytical toxicology
3 results on '"Matheux A"'

1. Liquid Chromatography–High-Resolution Mass Spectrometry (LC–HRMS) Analysis Following Voluntary Carvedilol Poisoning in a Subject with Cirrhosis: A Case Report

Author

Joseph Berthier, Agathe Pasquet, Pascal Guerard, and Alice Matheux

Subjects
Chemical Health and Safety, Health, Toxicology and Mutagenesis, Environmental Chemistry, Toxicology, Analytical Chemistry
Abstract

Accidental or intentional carvedilol poisoning is rarely reported. Here, we describe a case of attempted suicide with a large quantity of immediate-release carvedilol (75 mg) and alcohol. In order to determine the kinetics, liquid chromatography–high-resolution mass spectrometry analyses were performed. The results for the plasma concentration of carvedilol were 906 µg/L 3 h after ingestion, 288 µg/L 12 h after ingestion and 103 µg/L 24 h after ingestion. A one-compartment model with linear and first order best described the elimination of the carvedilol, and the estimated half-life was 5.8 h. The result 3 h after ingestion represented the highest concentration ever observed for this drug. However, the patient was cirrhotic, and liver function was impaired with decreased Factor V (45%) and prothrombin ratio (61%). These conditions may explain the high concentrations of carvedilol. The patient was treated with glucagon and discharged from the hospital the following day.

Published
2022

3. Liquid Chromatography–High-Resolution Mass Spectrometry (LC–HRMS) Analysis Following Voluntary Carvedilol Poisoning in a Subject with Cirrhosis: A Case Report.

Author

Berthier, Joseph, Pasquet, Agathe, Guerard, Pascal, and Matheux, Alice

Subjects
CARVEDILOL, MASS spectrometry, HOSPITAL admission & discharge, CIRRHOSIS of the liver, ATTEMPTED suicide, RIBAVIRIN
Abstract

Accidental or intentional carvedilol poisoning is rarely reported. Here, we describe a case of attempted suicide with a large quantity of immediate-release carvedilol (75 mg) and alcohol. In order to determine the kinetics, liquid chromatography–high-resolution mass spectrometry analyses were performed. The results for the plasma concentration of carvedilol were 906 µg/L 3 h after ingestion, 288 µg/L 12 h after ingestion and 103 µg/L 24 h after ingestion. A one-compartment model with linear and first order best described the elimination of the carvedilol, and the estimated half-life was 5.8 h. The result 3 h after ingestion represented the highest concentration ever observed for this drug. However, the patient was cirrhotic, and liver function was impaired with decreased Factor V (45%) and prothrombin ratio (61%). These conditions may explain the high concentrations of carvedilol. The patient was treated with glucagon and discharged from the hospital the following day. [ABSTRACT FROM AUTHOR]

Published
2023
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