1. The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia.
- Author
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Phyo, Aung Zaw Zaw, Gonzalez-Chica, David A., Stocks, Nigel P., Storey, Elsdon, Woods, Robyn L., Murray, Anne M., Orchard, Suzanne G., Shah, Raj C., Gasevic, Danijela, Freak-Poli, Rosanne, Ryan, Joanne, and ASPREE Investigator Group
- Subjects
QUALITY of life ,COGNITION disorders ,DEMENTIA ,GENDER ,OLDER people ,MENTAL health ,RESEARCH ,CROSS-sectional method ,RESEARCH methodology ,COGNITION ,DISEASE incidence ,MEDICAL cooperation ,EVALUATION research ,NEUROPSYCHOLOGICAL tests ,COMPARATIVE studies ,INDEPENDENT living ,QUESTIONNAIRES ,RESEARCH funding - Abstract
Background: Health-related quality of life (HRQoL) has been shown to predict adverse health outcome in the general population.Objective: We examined the cross-sectional association between HRQoL and cognitive performance at baseline. Next, we explored whether baseline HRQoL predicted 5-year incident cognitive decline and dementia and whether there were gender differences.Methods: 19,106 community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, aged 65-98 years, free of major cognitive impairments, and completed the HRQoL 12-item short-form (SF-12) at baseline (2010-2014), were followed until June 2017. The physical (PCS) and mental component scores (MCS) of SF-12 were calculated. The cognitive tests were assessed at baseline, year 1, 3, 5, and 7 or close-out visit. Cognitive decline was defined as > 1.5 SD drop from baseline on any of the cognitive tests. Dementia was adjudicated according to DSM-IV criteria. Linear and Cox proportional-hazards regressions were used to examine the cross-sectional and longitudinal associations respectively.Results: At baseline, higher PCS and MCS were associated with better cognition. Over a median 4.7-year follow-up, higher MCS was associated with a reduced risk of cognitive decline and dementia (12% and 15% respectively, per 10-unit increase) and a 10-unit higher PCS was associated with a 6% decreased risk of cognitive decline. PCS did not predict dementia incidence. Findings were not different by gender.Conclusion: Our study found that higher HRQoL, in particular MCS, predicted a reduced risk of cognitive decline and dementia over time in community-dwelling older people. [ABSTRACT FROM AUTHOR]- Published
- 2021
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