Search

Your search keyword '"Zhou, Xiaoying"' showing total 19 results
Start Over Author "Zhou, Xiaoying" Journal journal of allergy and clinical immunology
19 results on '"Zhou, Xiaoying"'

11. Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired

Author

Pellerin, Laurence, primary, Jenks, Jennifer Anne, additional, Chinthrajah, Sharon, additional, Dominguez, Tina, additional, Block, Whitney, additional, Zhou, Xiaoying, additional, Noshirvan, Arram, additional, Gregori, Silvia, additional, Roncarolo, Maria Grazia, additional, Nadeau, Kari Christine, additional, and Bacchetta, Rosa, additional

Published
2018
Full Text
View/download PDF

14. Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

Author

Hinks, Timothy S.C., primary, Zhou, Xiaoying, additional, Staples, Karl J., additional, Dimitrov, Borislav D., additional, Manta, Alexander, additional, Petrossian, Tanya, additional, Lum, Pek Y., additional, Smith, Caroline G., additional, Ward, Jon A., additional, Howarth, Peter H., additional, Walls, Andrew F., additional, Gadola, Stephan D., additional, and Djukanović, Ratko, additional

Published
2015
Full Text
View/download PDF

17. Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

Author

Hinks, Timothy, Zhou, Xiaoying, Staples, Karl J., Dimitrov, Borislav D., Manta, Alexander, Petrossian, Tanya, Lum, Pek Y., Smith, Caroline G., Ward, Jon A., Howarth, Peter H., Walls, Andrew F., Gadola, Stephan D., and Djukanović, Ratko

Subjects
TH2, mucosal-associated invariant T-cell, phenotype, Immunology, T lymphocytes, Immunology and Allergy, mast cells, TH17, endotype, Asthma, cytokines, regulatory T
Abstract

BackgroundAsthma is a chronic inflammatory disease involving diverse cells and mediators whose interconnectivity and relationships to asthma severity are unclear.ObjectiveWe performed a comprehensive assessment of TH17 cells, regulatory T cells, mucosal-associated invariant T (MAIT) cells, other T-cell subsets, and granulocyte mediators in asthmatic patients.MethodsSixty patients with mild-to-severe asthma and 24 control subjects underwent detailed clinical assessment and provided induced sputum, endobronchial biopsy, bronchoalveolar lavage, and blood samples. Adaptive and invariant T-cell subsets, cytokines, mast cells, and basophil mediators were analyzed.ResultsSignificant heterogeneity of T-cell phenotypes was observed, with levels of IL-13–secreting T cells and type 2 cytokines increased at some, but not all, asthma severities. TH17 cells and ??-17 cells, proposed drivers of neutrophilic inflammation, were not strongly associated with asthma, even in severe neutrophilic forms. MAIT cell frequencies were strikingly reduced in both blood and lung tissue in relation to corticosteroid therapy and vitamin D levels, especially in patients with severe asthma in whom bronchoalveolar lavage regulatory T-cell numbers were also reduced. Bayesian network analysis identified complex relationships between pathobiologic and clinical parameters. Topological data analysis identified 6 novel clusters that are associated with diverse underlying disease mechanisms, with increased mast cell mediator levels in patients with severe asthma both in its atopic (type 2 cytokine–high) and nonatopic forms.ConclusionThe evidence for a role for TH17 cells in patients with severe asthma is limited. Severe asthma is associated with a striking deficiency of MAIT cells and high mast cell mediator levels. This study provides proof of concept for disease mechanistic networks in asthmatic patients with clusters that could inform the development of new therapies.

Full Text
View/download PDF

19. Allergen-specific CD8 + T cells in peanut-allergic individuals.

Author

Yu W, Zhou X, Dunham D, Lyu SC, Manohar M, Zhang W, Zhao F, Davis MM, and Nadeau K

Subjects
Adolescent, Adult, Child, Child, Preschool, Female, Humans, Immunoglobulin E immunology, Male, Middle Aged, Young Adult, Allergens immunology, Arachis immunology, CD8-Positive T-Lymphocytes immunology, Peanut Hypersensitivity immunology, Peptides immunology, Plant Proteins immunology
Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results