12 results on '"Marnie Robinson"'
Search Results
2. The Efficacy and Safety of Probiotic and Peanut Oral Immunotherapy for inducing Desensitization and Sustained Unresponsiveness: Results from a Phase 2b Multi-center Randomized Trial (PPOIT-003)
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Dean Tey, Kuang-Chih Hsiao, Adriana Chebar Lozinsky, Mimi L.K. Tang, Marnie Robinson, Susan Fahy-Scheer, Michael O'Sullivan, Patrick Quinn, Jessica Metcalfe, Paxton Loke, Molly O'Sullivan, Christine Axelrad, Susan L. Prescott, Ee-Lyn Su, Michael Gold, and Francesca Orsini
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Probiotic ,Randomized controlled trial ,Oral immunotherapy ,law ,business.industry ,medicine.medical_treatment ,Immunology ,medicine ,Immunology and Allergy ,Pharmacology ,business ,law.invention ,Desensitization (medicine) - Published
- 2020
3. Increasing the accuracy of peanut allergy diagnosis by using Ara h 2
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Anne-Louise Ponsonby, Pamela E. Martin, Thanh D. Dang, Marnie Robinson, T. Tan, Mimi L.K. Tang, Lyle C. Gurrin, Katrina J. Allen, Paul V. Licciardi, Shyamali C. Dharmage, Dean Tey, Sharon Choo, and Jennifer J. Koplin
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Male ,Allergy ,Immunology ,Peanut allergy ,Population ,medicine.disease_cause ,Sensitivity and Specificity ,Allergen ,Food allergy ,medicine ,Humans ,Immunology and Allergy ,Peanut Hypersensitivity ,education ,Anaphylaxis ,Sensitization ,Glycoproteins ,Skin Tests ,education.field_of_study ,Oral food challenge ,business.industry ,fungi ,Infant ,Reproducibility of Results ,food and beverages ,Antigens, Plant ,Immunoglobulin E ,medicine.disease ,medicine.anatomical_structure ,Female ,business ,2S Albumins, Plant - Abstract
BACKGROUND: Measurement of whole peanut-specific IgE (sIgE) is often used to confirm sensitization but does not reliably predict allergy. Ara h 2 is the dominant peanut allergen detected in 90% to 100% of patients with peanut allergy and could help improve diagnosis. OBJECTIVES: We sought to determine whether Ara h 2 testing might improve the accuracy of diagnosing peanut allergy and therefore circumvent the need for an oral food challenge (OFC). METHODS: Infants from the population-based HealthNuts study underwent skin prick tests to determine peanut sensitization and subsequently underwent a peanut OFC to confirm allergy status. In a stratified random sample of 200 infants (100 with peanut allergy and 100 with peanut tolerance), whole peanut sIgE and Ara h 2 sIgE levels were quantified by using fluorescence enzyme immunoassay. RESULTS: By using the previously published 95% positive predictive value of 15 kU(A)/L for whole peanut sIgE, a corresponding specificity of 98% (95% CI, 93% to 100%) was found in this study cohort. At the equivalent specificity of 98%, the sensitivity of Ara h 2 sIgE is 60% (95% CI, 50% to 70%), correctly identifying 60% of subjects with true peanut allergy compared with only 26% correctly identified by using whole peanut sIgE. We report that when using a combined approach of plasma sIgE testing for whole peanut followed by Ara h 2 for the diagnosis of peanut allergy, the number of OFCs required is reduced by almost two thirds. CONCLUSION: Ara h 2 plasma sIgE test levels provide higher diagnostic accuracy than whole peanut plasma sIgE levels and could be considered a new diagnostic tool to distinguish peanut allergy from peanut tolerance, which might reduce the need for an OFC.
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- 2012
4. Reactions to Peanut during a Double-Blind Placebo Controlled Food Challenge (DBPCFC) for Enrolment in a Randomized Trial
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Paxton Loke, Francesca Orsini, Michael Gold, Mimi L.K. Tang, Michael O'Sullivan, Christine Axerald, Adriana Chebar Lozinsky, Kuang-Chih Hsiao, Patrick Quinn, Katarina Jane Allen, Dean Tey, Ee-Lyn Su, Susan L. Prescott, Anne-Louise Ponsonby, Sigrid Pitkin, and Marnie Robinson
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Double blind ,medicine.medical_specialty ,Randomized controlled trial ,business.industry ,law ,Internal medicine ,Immunology ,medicine ,Immunology and Allergy ,Placebo ,business ,law.invention - Published
- 2018
5. Administration of a probiotic with peanut oral immunotherapy: A randomized trial
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Ee Lyn Su, Susan Donath, Marnie Robinson, Anne-Louise Ponsonby, Paul V. Licciardi, Mimi L.K. Tang, Wesley Burks, Dean Tey, and Francesca Orsini
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Male ,medicine.medical_specialty ,Allergy ,Arachis ,medicine.medical_treatment ,Immunology ,Peanut allergy ,Administration, Oral ,Placebo ,Gastroenterology ,law.invention ,Probiotic ,Double-Blind Method ,Randomized controlled trial ,law ,Food allergy ,Internal medicine ,Humans ,Immunology and Allergy ,Medicine ,Peanut Hypersensitivity ,Child ,Skin Tests ,business.industry ,Probiotics ,Infant ,food and beverages ,Allergens ,Immunoglobulin E ,medicine.disease ,Tolerance induction ,Treatment Outcome ,Desensitization, Immunologic ,Child, Preschool ,Immunoglobulin G ,Female ,business ,Adjuvant - Abstract
Coadministration of a bacterial adjuvant with oral immunotherapy (OIT) has been suggested as a potential treatment for food allergy.To evaluate a combined therapy comprising a probiotic together with peanut OIT.We performed a double-blind, placebo-controlled randomized trial of the probiotic Lactobacillus rhamnosus CGMCC 1.3724 and peanut OIT (probiotic and peanut oral immunotherapy [PPOIT]) in children (1-10 years) with peanut allergy. The primary outcome was induction of sustained unresponsiveness 2 to 5 weeks after discontinuation of treatment (referred to as possible sustained unresponsiveness). Secondary outcomes were desensitization, peanut skin prick test, and specific IgE and specific IgG4 measurements.Sixty-two children were randomized and stratified by age (≤5 and5 years) and peanut skin test wheal size (≤10 and10 mm); 56 reached the trial's end. Baseline demographics were similar across groups. Possible sustained unresponsiveness was achieved in 82.1% receiving PPOIT and 3.6% receiving placebo (P.001). Nine children need to be treated for 7 to achieve sustained unresponsiveness (number needed to treat, 1.27; 95% CI, 1.06-1.59). Of the subjects, 89.7% receiving PPOIT and 7.1% receiving placebo were desensitized (P.001). PPOIT was associated with reduced peanut skin prick test responses and peanut-specific IgE levels and increased peanut-specific IgG4 levels (all P.001). PPOIT-treated participants reported a greater number of adverse events, mostly with maintenance home dosing.This is the first randomized placebo-controlled trial evaluating the novel coadministration of a probiotic and peanut OIT and assessing sustained unresponsiveness in children with peanut allergy. PPOIT was effective in inducing possible sustained unresponsiveness and immune changes that suggest modulation of the peanut-specific immune response. Further work is required to confirm sustained unresponsiveness after a longer period of secondary peanut elimination and to clarify the relative contributions of probiotics versus OIT.
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- 2015
6. The natural history and clinical predictors of egg allergy in the first 2 years of life: A prospective, population-based cohort study
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Katrina J. Allen, Shyamali C. Dharmage, Jennifer J. Koplin, Nicholas J. Osborne, Mimi L.K. Tang, Rachel L. Peters, Anne-Louise Ponsonby, Helen Czech, Adrian J. Lowe, Leone Thiele, Marnie Robinson, Lyle C. Gurrin, David J. Hill, and Dean Tey
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Male ,medicine.medical_specialty ,Eggs ,Immunology ,Population ,Filaggrin Proteins ,Risk Factors ,Food allergy ,Internal medicine ,Immune Tolerance ,medicine ,Humans ,Immunology and Allergy ,Prospective Studies ,Egg Hypersensitivity ,Prospective cohort study ,education ,Skin Tests ,education.field_of_study ,Oral food challenge ,business.industry ,Infant ,Odds ratio ,Immunoglobulin E ,medicine.disease ,Phenotype ,Child, Preschool ,Egg allergy ,embryonic structures ,Cohort ,Female ,business ,Cohort study - Abstract
Background There is a paucity of data examining the natural history of and risk factors for egg allergy persistence, the most common IgE-mediated food allergy in infants. Objective We aimed to assess the natural history of egg allergy and identify clinical predictors for persistent egg allergy in a population-based cohort. Methods The HealthNuts study is a prospective, population-based cohort study of 5276 infants who underwent skin prick tests to 4 allergens, including egg. Infants with a detectable wheal were offered hospital-based oral food challenges (OFCs) to egg, irrespective of skin prick test wheal sizes. Infants with challenge-confirmed raw egg allergy were offered baked egg OFCs at age 1 year and follow-up at age 2 years, with repeat OFCs to raw egg. Results One hundred forty infants with challenge-confirmed egg allergy at age 1 year participated in the follow-up. Egg allergy resolved in 66 (47%) infants (95% CI, 37% to 56%) by 2 years of age; however, resolution was lower in children with baked egg allergy at age 1 year compared with baked egg tolerance (13% and 56%, respectively; adjusted odds ratio, 5.27; 95% CI, 1.36-20.50; P = .02). In the subgroup of infants who were tolerant to baked egg at age 1 year, frequent ingestion of baked egg (≥5 times per month) compared with infrequent ingestion (0-4 times per month) increased the likelihood of tolerance (adjusted odds ratio, 3.52; 95% CI, 1.38-8.98; P = .009). Mutation in the filaggrin gene was not associated with the resolution of either egg allergy or egg sensitization at age 2 years. Conclusion Phenotyping of egg allergy (baked egg tolerant vs allergic) should be considered in the management of this allergy because it has prognostic implications and eases dietary restrictions. Randomized controlled trials for egg oral immunotherapy should consider stratifying at baseline by the baked egg subphenotype to account for the differential rate of tolerance development.
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- 2014
7. The Natural History and Clinical Predictors Of Egg Allergy In The First 2 Years Of Life: A Prospective, Population-Based, Cohort Study
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Rachel Peters, Shyamali Dharmage, Lyle Gurrin, Jennifer Koplin, Anne-Louise Ponsonby, Adrian Lowe, Mimi L.K. Tang, Dean Tey, David Hill, Marnie Robinson, Helen Czech, Leone Thiele, Nicholas Osborne, and Katrina Jane Allen
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Immunology ,Immunology and Allergy - Published
- 2014
8. Vitamin D insufficiency is associated with challenge-proven food allergy in infants
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Lyle C. Gurrin, Nicholas J. Osborne, Giovanni A. Zurzolo, Mimi L.K. Tang, Leone Thiele, Melissa Wake, Jeeva Sanjeevan, Marnie Robinson, Jennifer J. Koplin, Anne-Louise Ponsonby, Pamela E. Martin, Dean Tey, Hern-Tze Tina Tan, Katrina J. Allen, Thanh D. Dang, Shyamali C. Dharmage, David J. Hill, Helen Czech, Adrian J. Lowe, Deborah Anderson, Terence Dwyer, Peter Vuillermin, and Melanie C. Matheson
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medicine.medical_specialty ,Allergy ,Immunology ,Peanut allergy ,Population ,population ,vitamin D deficiency ,oral food challenge ,Food allergy ,Internal medicine ,medicine ,Vitamin D and neurology ,Immunology and Allergy ,Vitamin D ,education ,food allergy ,education.field_of_study ,Oral food challenge ,business.industry ,peanut allergy ,egg allergy ,medicine.disease ,Egg allergy ,eczema ,business ,epigenetic - Abstract
Background Epidemiological evidence has shown that pediatric food allergy is more prevalent in regions further from the equator, suggesting that vitamin D insufficiency may play a role in this disease. Objective To investigate the role of vitamin D status in infantile food allergy. Methods A population sample of 5276 one-year-old infants underwent skin prick testing to peanut, egg, sesame, and cow's milk or shrimp. All those with a detectable wheal and a random sample of participants with negative skin prick test results attended a hospital-based food challenge clinic. Blood samples were available for 577 infants (344 with challenge-proven food allergy, 74 sensitized but tolerant to food challenge, 159 negative on skin prick test and food challenge). Serum 25-hydroxyvitamin D levels were measured by using liquid chromatography tandem mass spectrometry. Associations between serum 25-hydroxyvitamin D and food allergy were examined by using multiple logistic regression, adjusting for potential risk and confounding factors. Results Infants of Australian-born parents, but not of parents born overseas, with vitamin D insufficiency (≤50 nmol/L) were more likely to be peanut (adjusted odds ratio [aOR], 11.51; 95% CI, 2.01-65.79; P = .006) and/or egg (aOR, 3.79; 95% CI, 1.19-12.08; P = .025) allergic than were those with adequate vitamin D levels independent of eczema status. Among those with Australian-born parents, infants with vitamin D insufficiency were more likely to have multiple food allergies (≥2) rather than a single food allergy (aOR, 10.48; 95% CI, 1.60-68.61 vs aOR, 1.82; 95% CI, 0.38-8.77, respectively). Conclusions These results provide the first direct evidence that vitamin D sufficiency may be an important protective factor for food allergy in the first year of life.
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- 2013
9. Vitamin D Insufficiency is Strongly Associated with Challenge-proven Infantile Food Allergy in the Healthnuts Population-based Study
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Katrina J. Allen, A. Lowe, Pamela E. Martin, A. Ponsonby, Mimi L.K. Tang, Shyamali C. Dharmage, Nicholas J. Osborne, Marnie Robinson, Lyle C. Gurrin, and Jennifer J. Koplin
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Population based study ,Pediatrics ,medicine.medical_specialty ,Allergy ,business.industry ,Food allergy ,Immunology ,medicine ,Vitamin D and neurology ,Immunology and Allergy ,business ,medicine.disease - Published
- 2012
10. Do Factors Known to Alter Infant Microbial Exposures Alter the Risk of Food Allergy and Eczema in a Population-based Infant Study?
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Mimi L.K. Tang, Jennifer J. Koplin, Shyamali C. Dharmage, Pamela E. Martin, Lyle C. Gurrin, Marnie Robinson, Nicholas J. Osborne, Katrina J. Allen, Adrian J. Lowe, and A. Ponsonby
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Food allergy ,business.industry ,Environmental health ,Immunology ,medicine ,Immunology and Allergy ,Population based ,medicine.disease ,business - Published
- 2012
11. Filaggrin Mutations are Associated with an Increased Risk of Infantile Food Allergy and Sensitization
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Thanh D. Dang, Shyamali C. Dharmage, A. Ponsonby, Nicholas J. Osborne, Melanie C. Matheson, Katrina J. Allen, Pamela E. Martin, T. Tan, Jennifer J. Koplin, Marnie Robinson, Justine A. Ellis, David J. Hill, Mimi L.K. Tang, and A. Lowe
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Allergy ,medicine.anatomical_structure ,Increased risk ,business.industry ,Food allergy ,Immunology ,Immunology and Allergy ,Medicine ,business ,medicine.disease ,Sensitization ,Filaggrin - Published
- 2012
12. Doctor - How Do I Use my Epipen?
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Sam Mehr, Mimi L.K. Tang, and Marnie Robinson
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Male ,Pediatrics ,medicine.medical_specialty ,Scoring system ,Medical staff ,Epinephrine ,Trainer ,education ,Immunology ,Patient Education as Topic ,Physicians ,Medical Staff, Hospital ,medicine ,Humans ,Immunology and Allergy ,Contributory factor ,Anaphylaxis ,business.industry ,Syringes ,Hospitals, Pediatric ,medicine.disease ,Accidental ,Pediatrics, Perinatology and Child Health ,Female ,Medical emergency ,business - Abstract
Parents and children who have been prescribed an Epipen are often unable to demonstrate its correct administration. One contributory factor may be that doctors are unfamiliar with the EpiPen and are unable to demonstrate the correct administration of the pen to the family. The aim of this study was to determine the rate of correct EpiPen demonstration by junior and Senior Medical Staff at a major tertiary paediatric Hospital. Junior and Senior medical staff were scored on their ability to correctly use the EpiPen trainer. A 6 step scoring system was used. One-hundred doctors were recruited (Residents n = 31, Senior Residents n = 39, Fellow/Consultants n = 30). Junior and Senior Medical staff had similar scores for EpiPen demonstration, the number that needed to read the EpiPen instructions prior to use and the frequancy of accidental self-injection into the thumb. Only two doctors (2%) demonstrated all 6 administration steps correctly. The most frequent errors made were not holding the pen in place for >5 seconds (57%), failure to apply pressure to activate (21%), and self-injection into the thumb (16%). Ninety five doctors needed to read the instructions, and of these, only 39 (41%) then proceeded to correctly demonstrate the remaining 5 steps. Forty-five doctors had previously dispensed an EpiPen, but only three demonstrated its use to parents/children with a trainer. The majority of doctors do not know how to use an Epipen and are unable to provide appropriate education to parents/children. In 37% of cases, the demonstration would not have delivered adrenaline to a patient.
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- 2006
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