Search

Your search keyword '"Wei, Xuetao"' showing total 5 results
Start Over Author "Wei, Xuetao" Journal journal of agricultural and food chemistry
5 results on '"Wei, Xuetao"'

3. Effects of Anthocyanin Extracts from Bilberry (Vaccinium myrtillus L.) and Purple Potato (Solanum tuberosum L. var. ‘Synkeä Sakari’) on the Plasma Metabolomic Profile of Zucker Diabetic Fatty Rats

Author

Chen, Kang, primary, Wei, Xuetao, additional, Zhang, Jian, additional, Pariyani, Raghunath, additional, Jokioja, Johanna, additional, Kortesniemi, Maaria, additional, Linderborg, Kaisa M., additional, Heinonen, Jari, additional, Sainio, Tuomo, additional, Zhang, Yumei, additional, and Yang, Baoru, additional

Published
2020
Full Text
View/download PDF

4. Effects of Anthocyanin Extracts from Bilberry (Vaccinium myrtillusL.) and Purple Potato (Solanum tuberosumL. var. ‘Synkeä Sakari’) on the Plasma Metabolomic Profile of Zucker Diabetic Fatty Rats

Author

Chen, Kang, Wei, Xuetao, Zhang, Jian, Pariyani, Raghunath, Jokioja, Johanna, Kortesniemi, Maaria, Linderborg, Kaisa M., Heinonen, Jari, Sainio, Tuomo, Zhang, Yumei, and Yang, Baoru

Abstract

This study compared the effects of the nonacylated and acylated anthocyanin-rich extracts on plasma metabolic profiles of Zucker diabetic fatty rats. The rats were fed with the nonacylated anthocyanin extract from bilberries (NAAB) or the acylated anthocyanin extract from purple potatoes (AAPP) at daily doses of 25 and 50 mg/kg body weight for 8 weeks. 1H NMR metabolomics was used to study the changes in plasma metabolites. A reduced fasting plasma glucose level was seen in all anthocyanin-fed groups, especially in the groups fed with NAAB. Both NAAB and AAPP decreased the levels of branched-chain amino acids and improved lipid profiles. AAPP increased the glutamine/glutamate ratio and decreased the levels of glycerol and metabolites involved in glycolysis, suggesting improved insulin sensitivity, gluconeogenesis, and glycolysis. AAPP decreased the hepatic TBC1D1and G6PCmessenger RNA level, suggesting regulation of gluconeogenesis and lipogenesis. This study indicated that AAPP and NAAB affected the plasma metabolic profile of diabetic rats differently.

Published
2020
Full Text
View/download PDF

5. 1 H NMR Metabolomics and Full-Length RNA-Seq Reveal Effects of Acylated and Nonacylated Anthocyanins on Hepatic Metabolites and Gene Expression in Zucker Diabetic Fatty Rats.

Author

Chen K, Wei X, Pariyani R, Kortesniemi M, Zhang Y, and Yang B

Subjects
Animals, Gene Expression, Metabolomics, Proton Magnetic Resonance Spectroscopy, RNA-Seq, Rats, Rats, Zucker, Anthocyanins, Diabetes Mellitus, Experimental
Abstract

Anthocyanins have been reported to possess antidiabetic effects. Recent studies indicate acylated anthocyanins have better stability and antioxidative activity compared to their nonacylated counterparts. This study compared the effects of nonacylated and acylated anthocyanins on hepatic gene expression and metabolic profile in diabetic rats, using full-length transcriptomics and 1 H NMR metabolomics. Zucker diabetic fatty (ZDF) rats were fed with nonacylated anthocyanin extract from bilberries (NAAB) or acylated anthocyanin extract from purple potatoes (AAPP) at daily doses of 25 and 50 mg/kg body weight for 8 weeks. Both anthocyanin extracts restored the levels of multiple metabolites (glucose, lactate, alanine, and pyruvate) and expression of genes ( G6pac , Pck1 , Pklr , and Gck ) involved in glycolysis and gluconeogenesis. AAPP decreased the hepatic glutamine level. NAAB regulated the expression of Mgat4a , Gstm6 , and Lpl , whereas AAPP modified the expression of Mgat4a , Jun , Fos , and Egr1 . This study indicated different effects of AAPP and NAAB on the hepatic transcriptomic and metabolic profiles of diabetic rats.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results