Search

Your search keyword '"Liu, Ju-Yun"' showing total 4 results
Start Over Author "Liu, Ju-Yun" Journal journal of agricultural and food chemistry
4 results on '"Liu, Ju-Yun"'

4. Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways.

Author

Liu JY, Yang FL, Lu CP, Yang YL, Wen CL, Hua KF, and Wu SH

Subjects
Animals, Cell Line, Dioscorea immunology, Macrophages drug effects, Macrophages immunology, Mice, Plant Extracts chemistry, Plant Extracts pharmacology, Polysaccharides chemistry, Dioscorea chemistry, Polysaccharides pharmacology, Protein Kinases immunology, Signal Transduction drug effects, Toll-Like Receptor 4 immunology, Tumor Necrosis Factor-alpha immunology
Abstract

The bioactive polysaccharides (named ZPF1) from yam ( Dioscorea batatas) were chemically determined, suggesting repeating beta-1,4-mannan as mainly having a feature of acetylation on C2-OH and C3-OH, around 28%. The ZPF1 participated in the stimulation of murine wild-type macrophages predominantly in tumor necrosis factor-alpha (TNFalpha). Toll-like receptor 4 is proved to be one of the cellular receptors in ZPF1-mediated TNFalpha secretion. Reactive oxygen species transmission and PI3-kinase are found necessary for regulating TNFalpha secretion by ZPF1 stimulation. Moreover, we found that extracellular signal-regulated kinase 1/2, Jun N-terminal kinase 1/2, and p38 mitogen-activated protein kinase play important roles in the regulation of TNFalpha secretion in ZPF1-stimulated macrophages.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results