1. Effects of bilberry (Vaccinium myrtillus) in combination with lactic acid bacteria on intestinal oxidative stress induced by ischemia-reperfusion in mouse.
- Author
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Jakesevic M, Xu J, Aaby K, Jeppsson B, Ahrné S, and Molin G
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal chemistry, Antioxidants chemistry, Fruit chemistry, Intestinal Mucosa blood supply, Intestinal Mucosa immunology, Intestinal Mucosa microbiology, Intestinal Mucosa pathology, Intestines immunology, Intestines microbiology, Intestines pathology, Ischemia immunology, Ischemia microbiology, Ischemia pathology, Lactobacillus plantarum growth & development, Lactobacillus plantarum isolation & purification, Male, Mice, Mice, Inbred BALB C, Pediococcus growth & development, Pediococcus isolation & purification, Random Allocation, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Antioxidants therapeutic use, Dietary Supplements analysis, Dietary Supplements microbiology, Intestines blood supply, Oxidative Stress, Reperfusion Injury prevention & control, Vaccinium myrtillus chemistry
- Abstract
Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A bilberry diet without addition of bacteria significantly decreased both lipid peroxidation (p = 0.001) and mucosal injury in the ileum. Of 14 anthocyanins identified in bilberry, anthocyanin arabinosides were the most resistant to absorption and microbial degradation in the intestines. Cyanidin-3-glucoside and delphinidin-3-glucoside seemed to be mostly absorbed in the stomach and upper part of the small intestine, while malvidin-3-galactoside, peonidin-3-glucoside, peonidin-3-galactoside, and petunidin-3-galactoside seemed to be digested by the microbiota in the cecum. Bilberry strongly influenced the composition of the cecal microbiota. In conclusion, a food supplement of bilberry protected small intestine against oxidative stress and inflammation induced by ischemia-reperfusion.
- Published
- 2013
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