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Background: Few studies have investigated depression-anxiety in adolescents/young adults in Greece. We examined the prevalence of depression/anxiety and its correlates in a large, representative, population-based sample of young Greeks. Methods: A structured telephone questionnaire was conducted in 2771 adolescents/young adults aged between 15 and 24 years (mean age: 20.47 ± 2.83 years). Depression/anxiety symptoms were assessed using the PHQ-9 and GAD-7 scales, respectively. Sociodemographics, mental health, and psychological parameters were also examined. Moderate to severe depression and anxiety symptoms were defined with PHQ-9≥10 and GAD-7≥10, respectively. Analysis was conducted using multivariable linear and logistic regression models. Results: In our sample, 803 (29%) and 416 (15%) participants reported depressive and anxiety symptoms, respectively. In multivariable analysis, depression was associated with female sex, younger age, mental health history, substance use, dyslexia, lower quality of life and social seclusion (all p

Background: Depression is a frequent and serious disease often undiagnosed in elderly. We aimed to examine (1) the prevalence/correlates associated with depression and (2) the magnitude of depression underdiagnosis/related factors, in a large community-dwelling elderly population in Crete/Greece visiting Primary Health Care (PHC) settings. Methods: A sub-sample of 2428 non-demented individuals with Mini Mental State Examination (MMSE)>19 were recruited from a population-based cohort of 3140 elderly (>60 years). In phase I, all participants were assessed with a structured questionnaire including demographics, life-style, sleep, physical health and cognitive function. Diagnosis of depression was based on history/treatment of depression. In phase II, in a sub-sample of 293 participants, depression was diagnosed after a thorough extensive neuropsychiatric/neuropsychological evaluation. Results: In phase I, 10.8% reported a diagnosis/treatment of depression. In multivariate analysis, female gender, lack of physical activity, caregiver dependence and use of benzodiazepines were associated with depression. In phase II, depression was prevalent in 28.7% of our sample, whereas about 61% of those diagnosed with depression were undetected in phase I. Factors associated with non-detection of depression were sleep complaints/subjective short sleep, low MMSE and medical comorbidities. Two screening questions related to mood increased possibility to detect undiagnosed depression up to 90%. Limitations: Due to the cross-sectional design, causality between correlated factors cannot be examined. Conclusion: Prevalence of depression is high and largely underdiagnosed in elderly in Crete/Greece. Sleep and memory complaints appear to be surrogate markers of depression, whereas screening mood in PHC settings may significantly increase detection of depression in elders.