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Your search keyword '"Quevedo, João"' showing total 34 results
Start Over Author "Quevedo, João" Journal journal of affective disorders
34 results on '"Quevedo, João"'

1. Prevalence of cognitive impairment and associated factors in older people

Author

Campos, Ana Carolina Brunatto Falchetti, Teixeira, Iara Gonçalves, Moraes, Nayara de Souza, Cadorin, Isabela de Jesus, Morelli, Patrícia Mariotto, Lidio, Adrielly Vargas, Medeiros, Eduarda Behenck, Garcez, Michelle Lima, Keller, Gabriela Serafim, Kucharska, Ewa, da Rosa, Maria Inês, Ceretta, Luciane Bisognin, Quevedo, João, and Budni, Josiane

Published
2024
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4. Stress levels, psychological symptoms, and C-reactive protein levels in COVID-19: A cross-sectional study

Author

de Azevedo Cardoso, Taiane, Silva, Ritele H., Fernandes, Jessica L., Arent, Camila O., Amboni, Graziela, Borba, Laura A., Padilha, Alex Paulo Z., Botelho, Maria Eduarda M., Maciel, Amanda L., Barichello, Tatiana, Morales, Rodrigo, Soares, Silvio José B., Bagatini, Margarete D., Dallagnol, Claudia, Brighenti, Marta Elisa, Ignácio, Zuleide Maria, Quevedo, João, Ceretta, Luciane B., and Réus, Gislaine Z.

Published
2023
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34. Antimanic activity of minocycline in a GBR12909-induced model of mania in mice: Possible role of antioxidant and neurotrophic mechanisms.

Author

de Queiroz, Ana Isabelle G, Chaves Filho, Adriano José Maia, Araújo, Tatiane da Silva, Lima, Camila Nayane Carvalho, Machado, Michel de Jesus Souza, Carvalho, André F, Vasconcelos, Silvania Maria Mendes, de Lucena, David Freitas, Quevedo, João, and Macedo, Danielle

Subjects
*THERAPEUTIC use of lithium, *ANIMAL experimentation, *ANTIOXIDANTS, *BIOLOGICAL models, *BRAIN, *HIPPOCAMPUS (Brain), *LITHIUM, *BIPOLAR disorder, *LIPID peroxidation (Biology), *MICE, *TRANQUILIZING drugs, *VALPROIC acid, *MINOCYCLINE, *PHARMACODYNAMICS, *THERAPEUTICS
Abstract

Background: Mania/hypomania is the cardinal feature of bipolar disorder. Recently, single administration of the dopamine transporter (DAT) inhibitor, GBR12909, was related to mania-like alterations. In the present study we aimed at testing behavioral and brain oxidant/neurotrophic alterations induced by the repeated administration of GBR12909 and its prevention/reversal by the mood stabilizing drugs, lithium (Li) and valproate (VAL) as well as by the neuroprotective drug, minocycline (Mino).Methods: Adult Swiss mice were submitted to 14 days protocols namely prevention and reversal. In the reversal protocol mice were given GBR12909 or saline and between days 8 and 14 received Li, VAL, Mino (25 or 50mg/kg) or saline. In the prevention treatment, mice were pretreated with Li, VAL, Mino or saline prior to GBR12909.Results: GBR12909 repeated administration induced hyperlocomotion and increased risk taking behavior that were prevented and reversed by the mood stabilizers and both doses of Mino. Li, VAL or Mino were more effective in the reversal of striatal GSH alterations induced by GBR12909. Regarding lipid peroxidation Mino was more effective in the prevention and reversal of lipid peroxidation in the hippocampus whereas Li and VAL prevented this alteration in the striatum and PFC. Li, VAL and Mino25 reversed the decrease in BDNF levels induced by GBR12909.Conclusion: GBR12909 repeated administration resembles manic phenotype. Similarly to classical mood-stabilizing agents, Mino prevented and reversed GBR12909 manic-like behavior in mice. Thus, our data provide preclinical support to the design of trials investigating Mino's possible antimanic effects. [ABSTRACT FROM AUTHOR]

Published
2017
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