1. Changes in life expectancy for cancer patients over time since diagnosis
- Author
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Botta, L., Dal Maso, L., Guzzinati, S., Panato, C., Gatta, G., Trama, A., Rugge, M., Tagliabue, G., Casella, C., Caruso, B., Michiara, M., Ferretti, S., Sensi, F., Tumino, R., Toffolutti, F., Russo, A. G., Caiazzo, A. L., Mangone, L., Mazzucco, W., Iacovacci, S., Ricci, P., Gola, G., Candela, G., Sardo, A. S., De Angelis, R., Buzzoni, C., Capocaccia, R., AIRTUM Working Group, Botta, Laura, Dal Maso, Luigino, Guzzinati, Stefano, Panato, Chiara, Gatta, Gemma, Trama, Annalisa, Rugge, Massimo, Tagliabue, Giovanna, Casella, Claudia, Caruso, Bianca, Michiara, Maria, Ferretti, Stefano, Sensi, Flavio, Tumino, Rosario, Toffolutti, Federica, Giampiero Russo, Antonio, Luisa Caiazzo, Anna, Mangone, Lucia, Mazzucco, Walter, Iacovacci, Silvia, Ricci, Paolo, Gola, Gemma, Candela, Giuseppa, Sutera Sardo, Antonella, De Angelis, Roberta, Buzzoni, Carlotta, and Capocaccia, Riccardo
- Subjects
0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,cancer survivor ,Life expectancy ,Cancer survivors ,Population ,YLL, years of life lost ,(ICD-O-3), international classification of diseases for oncology, third revision ,Socio-culturale ,Life expectancy, Population-based cancer registry, Relative survival, Cancer, Cancer survivors, Italy ,Settore MED/42 - Igiene Generale E Applicata ,Relative survival ,03 medical and health sciences ,0302 clinical medicine ,Health care ,Medicine ,education ,lcsh:Science (General) ,Population-based cancer registry ,Thyroid cancer ,Cancer ,RS, relative survival ,education.field_of_study ,lcsh:R5-920 ,Multidisciplinary ,business.industry ,Absolute risk reduction ,medicine.disease ,LE, life expectancy ,NHL, non-Hodgkin lymphoma ,030104 developmental biology ,Years of potential life lost ,Italy ,ISTAT, national institute of statistics ,030220 oncology & carcinogenesis ,(ICD-10), international classification of diseases tenth revision ,Original Article ,business ,lcsh:Medicine (General) ,lcsh:Q1-390 - Abstract
Highlights • Research question: how cancer impacts on LE changes during patients’ entire life • LE increased in patients surviving the first years and decreasing thereafter. • Patients’ LE in the end approached but seldom reached the general population’s LE. • This method describes when cancer survivors’ excess risk of death became negligible. • Life expectancy indicator is easy to be understood and interpreted by patients., Graphical abstract, The aims of this study were to provide life expectancy (LE) estimates of cancer patients at diagnosis and LE changes over time since diagnosis to describe the impact of cancer during patients' entire lives. Cancer patients' LE was calculated by standard period life table methodology using the relative survival of Italian patients diagnosed in population-based cancer registries in 1985–2011 with follow-up to 2013. Data were smoothed using a polynomial model and years of life lost (YLL) were calculated as the difference between patients' LE and that of the age- and sex-matched general population. The YLL at diagnosis was highest at the youngest age at diagnosis, steadily decreasing thereafter. For patients diagnosed at age 45 years, the YLL was above 20 for lung and ovarian cancers and below 6 for thyroid cancer in women and melanoma in men. LE progressively increased in patients surviving the first years, decreasing thereafter, to approach that of the general population. YLL in the long run mainly depends on attained age. Providing quantitative data is essential to better define clinical follow-up and plan health care resource allocation. These results help assess when the excess risk of death from tumour becomes negligible in cancer survivors.
- Published
- 2019