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1. 680 Multi-parametric assessment of the immune response to a trio immunotherapy in patients with recurrent or metastatic head and neck squamous cell carcinoma

Author: William L Redmond, Bernard A Fox, Tarsem Moudgil, Carlo Bifulco, Walter J Urba, Christopher Paustian, Hong-Ming Hu, Traci Hilton, Tyler Hulett, Yoshinobu Koguchi, Rom S Leidner, Shawn M Jensen, Brian Piening, Matthew H Taylor, Noriko Iwamoto, Takashi Shimada, Marcus Couey, Venkatesh Rajamanickam, Brady Bernard, Yuriko Minegishi, Lessli Rushforth, Ryan Meng, Tanisha Christie, R Bryan Bell, Koji Ueda, Noah Simons, Annie Stadum, Quyen Vu, and Abigail Peterson
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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2. 124 Location, location, location: spatial analysis of ultrahigh-plex immunofluorescence panel in head and neck cancer

Author: Bernard A Fox, Tarsem Moudgil, Christopher Paustian, Rom S Leidner, Shawn M Jensen, Venkatesh Rajamanickam, Oliver Braubach, Niyati Jhaveri, Aditya Pratapa, Noah Simons, and Quyen Vu
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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3. 679 Characterization of tumor specific CD8+ T cell responses in patients with recurrent/metastatic HPV16-positive head and neck cancer receiving HB-200 monotherapy as second or later line treatment in a phase 1 study

Author: Siqing Fu, Rom S Leidner, Ki Chung, Jiaxin Niu, Ilian Tchakov, Debra L Richardson, Xiaoping Qing, Jorge Nieva, Douglas Adkins, Alan L Ho, Minh Phan, Alexander T Pearson, Marshall R Posner, Lisle Nabell, Stuart Wong, Katerin Rojas, Ari J Rosenberg, Trisha Kaufmann, Christopher Plescia, Corinne Iacobucci, Kia Katchar, Klaus Orlinger, Katia Schlienger, and David G Pfister
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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4. 148 Characterizing cancer’s dark matter, short-lived proteins, and defective ribosomal products, presented by cancer and contained in the DPV-001 cancer vaccine

Author: William L Redmond, Bernard A Fox, Tarsem Moudgil, Carlo Bifulco, Walter J Urba, Hong-Ming Hu, Traci Hilton, Yoshinobu Koguchi, Rom S Leidner, Shawn M Jensen, Rachel E Sanborn, Brian Piening, Noriko Iwamoto, Takashi Shimada, Venkatesh Rajamanickam, Yuriko Minegishi, Ryan Meng, Tanisha Christie, Alexa Dowdell, R Bryan Bell, and Koji Ueda
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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5. First-in-human phase I/Ib study of NIZ985, a recombinant heterodimer of IL-15 and IL-15Rα, as a single agent and in combination with spartalizumab in patients with advanced and metastatic solid tumors

Author: Kevin Conlon, Robert Wesolowski, Douglas G McNeel, John A Thompson, Rom Leidner, Andrea Wang-Gillam, Sumati Gupta, Nancy Lewis, George N Pavlakis, Lang Ho Lee, Monica Chaudhari, Nadia Hassounah, Jong Bong Lee, and Jessica A O’Keeffe
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background Preclinically, interleukin-15 (IL-15) monotherapy promotes antitumor immune responses, which are enhanced when IL-15 is used in combination with immune checkpoint inhibitors (ICIs). This first-in-human study investigated NIZ985, a recombinant heterodimer comprising physiologically active IL-15 and IL-15 receptor α, as monotherapy and in combination with spartalizumab, an anti-programmed cell death protein-1 (anti-PD-1) monoclonal antibody, in patients with advanced solid tumors.Methods This phase I/Ib study had two dose-escalation arms: single-agent NIZ985 administered subcutaneously thrice weekly (TIW, 2 weeks on/2 weeks off) or once weekly (QW, 3 weeks on/1 week off), and NIZ985 TIW or QW administered subcutaneously plus spartalizumab (400 mg intravenously every 4 weeks (Q4W)). The dose-expansion phase investigated NIZ985 1 µg/kg TIW/spartalizumab 400 mg Q4W in patients with anti-PD-1–sensitive or anti-PD-1–resistant tumor types stratified according to approved indications. The primary objectives were the safety, tolerability, and the maximum tolerated doses (MTDs) and/or recommended dose for expansion (RDE) of NIZ985 for the dose-expansion phase.Results As of February 17, 2020, 83 patients (median age: 63 years; range: 28–85) were treated in dose escalation (N=47; single-agent NIZ985: n=27; NIZ985/spartalizumab n=20) and dose expansion (N=36). No dose-limiting toxicities occurred nor was the MTD identified. The most common treatment-related adverse event (TRAE) was injection site reaction (primarily grades 1–2; single-agent NIZ985: 85% (23/27)); NIZ985/spartalizumab: 89% [50/56]). The most common grade 3–4 TRAE was decreased lymphocyte count (single-agent NIZ985: 7% [2/27]; NIZ985/spartalizumab: 5% [3/56]). The best overall response was stable disease in the single-agent arm (30% (8/27)) and partial response in the NIZ985/spartalizumab arm (5% [3/56]; melanoma, pancreatic cancer, gastric cancer). In dose expansion, the disease control rate was 45% (5/11) in the anti-PD-1–sensitive and 20% (5/25) in the anti-PD-1–resistant tumor type cohorts. Pharmacokinetic parameters were similar across arms. The transient increase in CD8+ T cell and natural killer cell proliferation and induction of several cytokines occurred in response to the single-agent and combination treatments.Conclusions NIZ985 was well tolerated in the single-agent and NIZ985/spartalizumab regimens. The RDE was established at 1 µg/kg TIW. Antitumor activity of the combination was observed against tumor types known to have a poor response to ICIs.Trial registration number NCT02452268.
Published: 2023
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6. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)

Author: Cohen, Ezra EW, Bell, R Bryan, Bifulco, Carlo B, Burtness, Barbara, Gillison, Maura L, Harrington, Kevin J, Le, Quynh-Thu, Lee, Nancy Y, Leidner, Rom, Lewis, Rebecca L, Licitra, Lisa, Mehanna, Hisham, Mell, Loren K, Raben, Adam, Sikora, Andrew G, Uppaluri, Ravindra, Whitworth, Fernanda, Zandberg, Dan P, and Ferris, Robert L
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Vaccine Related, Immunization, Cancer, Clinical Research, Dental/Oral and Craniofacial Disease, Rare Diseases, Orphan Drug, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, B7-H1 Antigen, Consensus, Drug Approval, Head and Neck Neoplasms, Humans, Immunotherapy, Patient Selection, Practice Guidelines as Topic, Societies, Medical, Squamous Cell Carcinoma of Head and Neck, United States, United States Food and Drug Administration, Guidelines, Head and neck cancer, Head and neck squamous cell carcinoma, Immune checkpoint inhibitor, Oncology and carcinogenesis
Abstract: Head and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and 380,000 deaths worldwide per annum, and account for over 10,000 annual deaths in the United States alone. Improvement in outcomes are needed for patients with recurrent and or metastatic squamous cell carcinoma of the head and neck (HNSCC). In 2016, the US Food and Drug Administration (FDA) granted the first immunotherapeutic approvals - the anti-PD-1 immune checkpoint inhibitors nivolumab and pembrolizumab - for the treatment of patients with recurrent squamous cell carcinoma of the head and neck (HNSCC) that is refractory to platinum-based regimens. The European Commission followed in 2017 with approval of nivolumab for treatment of the same patient population, and shortly thereafter with approval of pembrolizumab monotherapy for the treatment of recurrent or metastatic HNSCC in adults whose tumors express PD-L1 with a ≥ 50% tumor proportion score and have progressed on or after platinum-containing chemotherapy. Then in 2019, the FDA granted approval for PD-1 inhibition as first-line treatment for patients with metastatic or unresectable, recurrent HNSCC, approving pembrolizumab in combination with platinum and fluorouracil for all patients with HNSCC and pembrolizumab as a single agent for patients with HNSCC whose tumors express a PD-L1 combined positive score ≥ 1. These approvals marked the first new therapies for these patients since 2006, as well as the first immunotherapeutic approvals in this disease. In light of the introduction of these novel therapies for the treatment of patients with head and neck cancer, The Society for Immunotherapy of Cancer (SITC) formed an expert committee tasked with generating consensus recommendations for emerging immunotherapies, including appropriate patient selection, therapy sequence, response monitoring, adverse event management, and biomarker testing. These consensus guidelines serve as a foundation to assist clinicians' understanding of the role of immunotherapies in this disease setting, and to standardize utilization across the field for patient benefit. Due to country-specific variances in approvals, availability and regulations regarding the discussed agents, this panel focused solely on FDA-approved drugs for the treatment of patients in the U.S.
Published: 2019

7. Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

Author: Kevin Conlon, Douglas G McNeel, John A Thompson, Sema Kurtulus, Rom Leidner, Thomas A Waldmann, Andrea Wang-Gillam, William D Figg, Sumati Gupta, Cristina Bergamaschi, George N Pavlakis, Antonio Valentin, Barbara K Felber, Mario Roederer, Dionysios C Watson, Cody J Peer, E Lake Potter, Nehal S Parikh, Debby Long, Lang Ho Lee, Niladri Roy Chowdhury, and Florent Bender
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2021
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8. Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial

Author: Bin Li, Jun Li, Tian Chen, Uwe M Martens, Lazar Vujanovic, Rom Leidner, Robert L Ferris, William Sharfman, Chrisann Kyi, Suzanne L Topalian, Janis M Taube, Christine H Chung, William C Spanos, Anthony Gonçalves, Lot A Devriese, Helene Gauthier, Simon I Chiosea, Julie E Stein, and Adam Barrows
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background Head and neck squamous cell carcinomas (HNSCCs) are common malignancies caused by carcinogens, including tobacco and alcohol, or infection with human papillomavirus (HPV). Immune checkpoint inhibitors targeting the programmed cell death 1 (PD-1) pathway are effective against unresectable recurrent/metastatic HNSCC. Here, we explored the safety and efficacy of anti-PD-1 therapy in at-risk resectable HPV-positive and HPV-negative HNSCC in the neoadjuvant setting.Methods The phase I/II CheckMate 358 trial in virus-associated cancers assessed neoadjuvant nivolumab in patients with previously untreated, resectable HPV-positive or HPV-negative HNSCC. Patients received nivolumab 240 mg intravenously on days 1 and 15, with surgery planned by day 29. Safety/tolerability (primary endpoint) was assessed by monitoring adverse events (AEs) and surgical delays. Radiographic response was measured before surgery using RECIST v1.1, adapted for a single post-nivolumab evaluation. Pathologic specimens were examined for treatment response using immune-based criteria.Results From November 2015 to December 2017, 52 patients with AJCC (seventh edition) stage III–IV resectable HNSCC received neoadjuvant nivolumab (26 HPV-positive, 26 HPV-negative). Any-grade treatment-related AEs (TRAEs) occurred in 19 patients (73.1%) and 14 patients (53.8%) in the HPV-positive and HPV-negative cohorts, respectively; grade 3–4 TRAEs occurred in five (19.2%) and three patients (11.5%), respectively. No patient had a protocol-defined TRAE-related surgical delay (>4 weeks). Thirty-eight patients were reported as undergoing complete surgical resection, 10 had a planned post-nivolumab biopsy instead of definitive surgery due to a protocol misinterpretation, and four did not undergo surgery or biopsy, including two with tumor progression. Radiographic response rates in 49 evaluable patients were 12.0% and 8.3% in the HPV-positive and HPV-negative cohorts, respectively. There were no complete pathologic responses by site or central review in operated patients. Among 17 centrally evaluable HPV-positive tumors, one (5.9%) achieved major pathological response and three (17.6%) achieved partial pathologic response (pPR); among 17 centrally evaluable HPV-negative tumors, one (5.9%) achieved pPR.Conclusions Neoadjuvant nivolumab was generally safe and induced pathologic regressions in HPV-positive (23.5%) and HPV-negative (5.9%) tumors. Combinatorial neoadjuvant treatment regimens, and continued postoperative therapy for high-risk tumors, are warranted in future trials to enhance the efficacy of this approach.Trial registration number ClinicalTrials.gov NCT02488759; https://clinicaltrials.gov/ct2/show/NCT02488759.
Published: 2021
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9. Delayed immune-related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance

Author: Marcus A. Couey, R. Bryan Bell, Ashish A. Patel, Meghan C. Romba, Marka R. Crittenden, Brendan D. Curti, Walter J. Urba, and Rom S. Leidner
Subjects: Immunotherapy, Checkpoint inhibitor, Costimulatory agonist, Delayed toxicity, Immune-related adverse events, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background The risk of delayed autoimmunity occurring months or years after discontinuation of immunotherapy is frequently asserted in the literature. However, specific cases were rarely described until 2018, when a wave of reports surfaced. With expanding I-O indications in the adjuvant/neoadjuvant curative setting, growing numbers of patients will receive limited courses of immunotherapy before entering routine surveillance. In this context, under-recognition of DIRE could pose a growing clinical hazard. Methods The aim of this study was to characterize DIRE through identification of existing reports of delayed post-treatment irAE in cancer patients treated with immunotherapy. We performed a PubMed literature review from 2008 through 2018 to determine the median data safety reporting window from existing I-O clinical trials, which we then applied to define the DIRE cutoff, and collated all qualifying reports over the same time span. DIRE was defined as new immune-related adverse events (irAE) manifesting ≥90 days after discontinuation of immunotherapy. Results Median duration of I-O clinical trials data safety reporting was 90 days (82% ≤ 90 days). DIRE cutoff was thus set as ≥90 days post-immunotherapy. We identified 23 qualifying cases; 21 by literature review and 2 from our institution. Median off-treatment interval to DIRE was 6 months (range: 3 to 28). Median cumulative immunotherapy exposure was 4 doses (range: 3 to 42). Involvement included endocrine, neurologic, GI, pulmonary, cardiac, rheumatologic and dermatologic irAE. Conclusions As immunotherapy indications expand into the curative setting, often with brief exposure and potentially sequenced with multimodality treatments, it will be necessary to recognize an emerging diagnostic complex, which we have termed delayed immune-related events (DIRE). Clinical vigilance has the potential to reduce morbidity from diagnostic delay, as irAE are generally manageable with prompt initiation of treatment – or from misdiagnosis - as misattribution can lead to unnecessary or harmful interventions as we describe. DIRE should therefore figure prominently in the differential diagnosis of patients presenting with illnesses of unclear etiology, irrespective of intervening treatments or interval post-immunotherapy, both of which can confound diagnosis. Increased recognition will rest on delineation of DIRE as a clinical diagnostic entity.
Published: 2019
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10. 407 Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors

Author: Adil Daud, Rom Leidner, Ezra Cohen, Matthew Reilley, Siwen Hu-Lieskovan, Raphael Clynes, Roger Cohen, John Thompson, Mark Stein, Alain Mita, Bartosz Chmielowski, Yana Najjar, Elaine Shum, R Donald Harvey, Catherine Fleener, Ying Ding, Sowmya Chollate, Hector Avina, Jolene Shorr, and Barbara Hickingbottom
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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11. 443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response

Author: Rom Leidner, Tarsem Moudgil, Carlo Bifulco, Bernard Fox, Christopher Paustian, Hong-Ming Hu, Traci Hilton, Rachel Sanborn, Bryan Bell, Shawn Jensen, Adi Mehta, Fridtjof Lund-Johansen, Madeleine Laws, Glenna McDonnell, Carmen Ballesteros Merino, and Marcus Couey
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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12. New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016

Author: Prasad S. Adusumilli, Edward Cha, Mark Cornfeld, Thomas Davis, Adi Diab, Thomas W. Dubensky, Elizabeth Evans, Jane L. Grogan, Bryan A. Irving, Rom S. Leidner, Shane A. Olwill, Patrick Soon-Shiong, Frederic Triebel, David Tuck, Adrian Bot, Roger D. Dansey, Charles G. Drake, Gordon J. Freeman, Ramy Ibrahim, Salil Patel, and Daniel S. Chen
Subjects: Immunotherapy, Cancer, Checkpoint inhibitors, PD-1, Combination therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract This report is a summary of ‘New Cancer Immunotherapy Agents in Development’ program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland. Presenters gave brief overviews of emerging clinical and pre-clinical immune-based agents and combinations, before participating in an extended panel discussion with multidisciplinary leaders, including members of the FDA, leading academic institutions and industrial drug developers, to consider topics relevant to the future of cancer immunotherapy.
Published: 2017
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13. Delayed immune-related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance

Author: Couey, Marcus A., Bell, R. Bryan, Patel, Ashish A., Romba, Meghan C., Crittenden, Marka R., Curti, Brendan D., Urba, Walter J., and Leidner, Rom S.
Published: 2019
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14. Responses of metastatic basal cell and cutaneous squamous cell carcinomas to anti-PD1 monoclonal antibody REGN2810

Author: Rom Leidner, Carlo Bifulco, Israel Lowy, Gerald S. Falchook, Elizabeth Stankevich, Brian Piening, and Matthew G. Fury
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) share exposure to UV light as the dominant risk factor, and these tumors therefore harbor high mutation burdens. In other malignancies, high mutation burden has been associated with clinical benefit from therapy with antibodies directed against the Programmed Death 1 (PD-1) immune checkpoint receptor. Highly mutated tumors are more likely to express immunogenic tumor neoantigens that attract effector T cells, which can be unleashed by blockade of the PD-1 immune checkpoint.Case presentations This report describes a patient with metastatic BCC and a patient with metastatic CSCC who were treated with REGN2810, a fully human anti-PD-1 monoclonal antibody, in an ongoing phase 1 trial (NCT02383212). The CSCC patient has experienced an ongoing complete response (16+ months), and the BCC patient has experienced an ongoing partial response (12+ months).Conclusions These case reports suggest that UV-associated skin cancers, beyond melanoma, are sensitive to PD-1 blockade.Trial registration Clinicaltrials.gov NCT02383212. Registered 2 February 2015.
Published: 2016
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15. 523 Preliminary clinical experience with XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors

Author: Catherine Fleener, Raphael Clynes, Ezra E.W. Cohen, Bartosz Chmielowski, Shubham Pant, Ying Ding, Joaquina Baranda, Barbara Hickingbottom, Rom Leidner, Yana G. Najjar, Adil Daud, Lei Bao, Roger B. Cohen, Siwen Hu-Lieskovan, Anthony F. Shields, Alain C. Mita, John A. Thompson, Elaine Shum, Sowmya Chollate, Matthew J. Reilley, Mark N. Stein, R. Donald Harvey, and Jolene Shorr
Subjects: Pharmacology, Oncology, Cancer Research, medicine.medical_specialty, Myeloid, business.industry, Melanoma, Immunology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Rash, Prostate cancer, medicine.anatomical_structure, Renal cell carcinoma, Internal medicine, Pharmacodynamics, medicine, Molecular Medicine, Immunology and Allergy, medicine.symptom, Ovarian cancer, Adverse effect, business, RC254-282
Abstract: BackgroundXmAb20717 is a humanized bispecific monoclonal antibody that simultaneously targets PD-1 and CTLA-4. We report updated data on patients treated at the recommended expansion dose from an ongoing, multicenter, Phase 1, dose-escalation and -expansion study of intravenous XmAb20717 in patients with selected advanced solid tumors that progressed after treatment with all standard therapies or with no standard therapeutic options.MethodsA maximum tolerated dose was not reached in dose escalation. XmAb20717 10 mg/kg every 2 weeks (Q2W) was selected as the expansion dose, based on consistent T-cell proliferation in peripheral blood indicative of dual PD-1/CTLA-4 checkpoint blockade, and response to treatment (RECIST[1.1]).1 Parallel expansion cohorts included ~20 patients each with melanoma, renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC), castration-resistant prostate cancer (CRPC), and a basket of tumor types without an FDA-approved checkpoint inhibitor (CI). Patients treated with 10 mg/kg in dose escalation were pooled with expansion cohorts for analysis of clinical activity and safety.ResultsAs of 9 June 2021, 110 patients, ranging in age from 39 to 89 years and 66.4% male, were treated, and 5 were continuing treatment. Patients had received a median of 4 prior systemic treatment regimens, including CI therapy for 64.5%. The objective response rate was 13.0% (10/77 patients evaluable for efficacy), including 1 complete response (melanoma [confirmed]) and 9 partial responses (confirmed: 1 melanoma, 2 RCC, 2 CRPC, 1 ovarian cancer; unconfirmed: 1 melanoma, 2 NSCLC). The CRPC responders (2/7 with RECIST-measurable disease) had confirmed PSA decreases ≥ 50% from baseline (to 0.02 and 0.3 ng/mL); neither had progression on bone scans. All responders had prior CI exposure, except those with CRPC. Robust CD4 and CD8 T-cell activation was seen. Low baseline tumoral expression of myeloid recruitment genes, including IL-8, was associated with clinical benefit. Grade ≥ 3 immunotherapy-related adverse events in ≥ 3 patients included rash (16.4%), transaminase elevations (9.1%), hyperglycemia (4.5%), acute kidney injury (3.6%), amylase and lipase increased (2.7%), and lipase increased (2.7%).ConclusionsPreliminary data indicate 10 mg/kg XmAb20717 Q2W was associated with complete and partial responses in multiple tumor types and was generally well-tolerated in these heavily pretreated patients with advanced cancer. Changes in T-cell populations in the periphery and tumor are consistent with robust dual checkpoint blockade. These findings support further development of XmAb20717 in advanced solid tumors, including metastatic prostate cancer.Trial RegistrationNCT03517488ReferencesShum E, Daud A, Reilley M, et al. Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors. JITC 2020;8(3):A247-8.Ethics ApprovalThe study was approved by each institution’s IRB.
Published: 2021

16. Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial

Author: Lazar Vujanovic, Jun Li, Anthony Gonçalves, Julie E. Stein, Chrisann Kyi, Rom Leidner, Christine H. Chung, Hélène Gauthier, Janis M. Taube, Uwe M Martens, Tian Chen, Robert L. Ferris, William H. Sharfman, Bin Li, Simon I. Chiosea, Lot A. Devriese, William C. Spanos, Suzanne L. Topalian, and Adam Barrows
Subjects: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Immunology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biopsy, Clinical endpoint, Immunology and Allergy, Medicine, Stage (cooking), Adverse effect, RC254-282, Pharmacology, medicine.diagnostic_test, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunotherapy, 030104 developmental biology, Tolerability, Tumor progression, 030220 oncology & carcinogenesis, Molecular Medicine, Nivolumab, business
Abstract: BackgroundHead and neck squamous cell carcinomas (HNSCCs) are common malignancies caused by carcinogens, including tobacco and alcohol, or infection with human papillomavirus (HPV). Immune checkpoint inhibitors targeting the programmed cell death 1 (PD-1) pathway are effective against unresectable recurrent/metastatic HNSCC. Here, we explored the safety and efficacy of anti-PD-1 therapy in at-risk resectable HPV-positive and HPV-negative HNSCC in the neoadjuvant setting.MethodsThe phase I/II CheckMate 358 trial in virus-associated cancers assessed neoadjuvant nivolumab in patients with previously untreated, resectable HPV-positive or HPV-negative HNSCC. Patients received nivolumab 240 mg intravenously on days 1 and 15, with surgery planned by day 29. Safety/tolerability (primary endpoint) was assessed by monitoring adverse events (AEs) and surgical delays. Radiographic response was measured before surgery using RECIST v1.1, adapted for a single post-nivolumab evaluation. Pathologic specimens were examined for treatment response using immune-based criteria.ResultsFrom November 2015 to December 2017, 52 patients with AJCC (seventh edition) stage III–IV resectable HNSCC received neoadjuvant nivolumab (26 HPV-positive, 26 HPV-negative). Any-grade treatment-related AEs (TRAEs) occurred in 19 patients (73.1%) and 14 patients (53.8%) in the HPV-positive and HPV-negative cohorts, respectively; grade 3–4 TRAEs occurred in five (19.2%) and three patients (11.5%), respectively. No patient had a protocol-defined TRAE-related surgical delay (>4 weeks). Thirty-eight patients were reported as undergoing complete surgical resection, 10 had a planned post-nivolumab biopsy instead of definitive surgery due to a protocol misinterpretation, and four did not undergo surgery or biopsy, including two with tumor progression. Radiographic response rates in 49 evaluable patients were 12.0% and 8.3% in the HPV-positive and HPV-negative cohorts, respectively. There were no complete pathologic responses by site or central review in operated patients. Among 17 centrally evaluable HPV-positive tumors, one (5.9%) achieved major pathological response and three (17.6%) achieved partial pathologic response (pPR); among 17 centrally evaluable HPV-negative tumors, one (5.9%) achieved pPR.ConclusionsNeoadjuvant nivolumab was generally safe and induced pathologic regressions in HPV-positive (23.5%) and HPV-negative (5.9%) tumors. Combinatorial neoadjuvant treatment regimens, and continued postoperative therapy for high-risk tumors, are warranted in future trials to enhance the efficacy of this approach.Trial registration numberClinicalTrials.gov NCT02488759; https://clinicaltrials.gov/ct2/show/NCT02488759.
Published: 2021

17. Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

Author: Conlon, Kevin, primary, Watson, Dionysios C, additional, Waldmann, Thomas A, additional, Valentin, Antonio, additional, Bergamaschi, Cristina, additional, Felber, Barbara K, additional, Peer, Cody J, additional, Figg, William D, additional, Potter, E Lake, additional, Roederer, Mario, additional, McNeel, Douglas G, additional, Thompson, John A, additional, Gupta, Sumati, additional, Leidner, Rom, additional, Wang-Gillam, Andrea, additional, Parikh, Nehal S, additional, Long, Debby, additional, Kurtulus, Sema, additional, Ho Lee, Lang, additional, Chowdhury, Niladri Roy, additional, Bender, Florent, additional, and Pavlakis, George N, additional
Published: 2021
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18. Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma

Author: Amber L. Watters, Marcus Couey, Carlo Bifulco, Yaping Wu, Walter J. Urba, Kristina H. Young, Michael J. Gough, R. Bryan Bell, Rom Leidner, Hong Xiao, Lessli Rushforth, Marka R. Crittenden, Allen C. Cheng, Ashish A. Patel, Shorin Nemeth, and George Morris
Subjects: 0301 basic medicine, Oncology, Male, Cancer Research, Time Factors, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Oregon, 0302 clinical medicine, Clinical endpoint, Immunology and Allergy, Immune Checkpoint Inhibitors, Neoadjuvant therapy, RC254-282, Clinical/Translational Cancer Immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Neoadjuvant Therapy, drug therapy, Nivolumab, Treatment Outcome, 030220 oncology & carcinogenesis, Radioimmunotherapy, Molecular Medicine, Female, immunotherapy, medicine.medical_specialty, Immunology, Radiosurgery, 03 medical and health sciences, Pharmacotherapy, head and neck neoplasms, Internal medicine, medicine, Humans, Aged, Neoplasm Staging, Pharmacology, combination, business.industry, Squamous Cell Carcinoma of Head and Neck, Head and neck cancer, medicine.disease, Head and neck squamous-cell carcinoma, Clinical trial, 030104 developmental biology, radioimmunotherapy, Radiotherapy, Adjuvant, Dose Fractionation, Radiation, business
Abstract: BackgroundCheckpoint inhibitors targeting programmed death receptor-1 (PD-1) have been tested in the neoadjuvant setting for the treatment of locoregionally advanced head and neck squamous cell carcinoma (HNSCC); however, response rates are modest. We hypothesized that adding stereotactic body radiation therapy (SBRT) to anti-PD-1 would be safe prior to definitive surgical resection and would enhance pathological response compared with historical cohorts of patients with locoregionally advanced HNSCC treated with checkpoint inhibitor alone.MethodsThe Neoadjuvant Immuno-Radiotherapy Trial was an investigator-initiated single institution phase Ib clinical trial that enrolled patients with previously untreated locally advanced HPV-positive and HPV-negative HNSCC between 2018 and 2019. Eligible patients were treated with neoadjuvant SBRT at a total dose of either 40 Gy in 5 fractions or 24 Gy in 3 fractions, delivered in a 1-week timespan, with or without nivolumab, prior to definitive surgical resection. Patients were then planned for treatment with adjuvant nivolumab for 3 months. The primary safety endpoint was unplanned delay in surgery considered to be at least possibly related to neoadjuvant treatment. The primary efficacy endpoints included pathological complete response (pCR), major pathological response (mPR), and the rate of clinical to pathological downstaging after neoadjuvant treatment.ResultsTwenty-one patients underwent neoadjuvant treatment, which was well tolerated and did not delay surgery, thus meeting the primary endpoint. Tissue responses were characterized by robust inflammatory infiltrates in the regression bed, plasma cells and cholesterol clefts. Among the entire study group, the mPR and pCR rate was 86% and 67%, respectively. Clinical to pathological downstaging occurred in 90% of the patients treated.ConclusionThese data demonstrate that radiation delivered only to the gross tumor volume combined with immunotherapy was safe, resulted in a high rate of mPR and should be further evaluated as a locally focused neoadjuvant therapy for patients with head and neck cancer.Trial registration numberThis study is registered with clinicaltrials.gov (NCT03247712) and is active, but closed to patient accrual.
Published: 2021

19. Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

Author: Yaping Wu, Brendan D. Curti, Zhaoyu Sun, William L. Redmond, Brady Bernard, Christopher B. Fountain, Peter G. Traber, Takashi Shimada, Yoshinobu Koguchi, Rom Leidner, Eliezer Zomer, Elizabeth Sturgill, George Morris, Venkatesh Rajamanickam, Noriko Iwamoto, Annah S Rolig, Ian Hilgart-Martiszus, J. Rex Horton, Shu Ching Chang, and Harold Shlevin
Subjects: 0301 basic medicine, Oncology, Male, Cancer Research, Time Factors, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Pembrolizumab, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Immunology and Allergy, Immune Checkpoint Inhibitors, T-lymphocytes, RC254-282, Clinical/Translational Cancer Immunotherapy, clinical trials as topic, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Blood Proteins, Middle Aged, Treatment Outcome, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, immunohistochemistry, Molecular Medicine, Pectins, Female, Multiple Myeloma, Adult, medicine.medical_specialty, Galectins, Immunology, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, Memory T Cells, Immune system, Internal medicine, medicine, Humans, Aged, Pharmacology, Autoimmune disease, business.industry, Squamous Cell Carcinoma of Head and Neck, Myeloid-Derived Suppressor Cells, Immunotherapy, medicine.disease, Head and neck squamous-cell carcinoma, Blockade, 030104 developmental biology, Myeloid-derived Suppressor Cell, business, CD8
Abstract: BackgroundPD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppression that contribute to immunotherapy resistance. We hypothesized that Gal-3 blockade with belapectin (GR-MD-02) plus anti-PD-1 (pembrolizumab) would enhance tumor response in patients with metastatic melanoma (MM) and head and neck squamous cell carcinoma (HNSCC).MethodsWe performed a phase I dose escalation study of belapectin+pembrolizumab in patients with advanced MM or HNSCC (NCT02575404). Belapectin was administered at 2, 4, or 8 mg/kg IV 60 min before pembrolizumab (200 mg IV every 3 weeks for five cycles). Responding patients continued pembrolizumab monotherapy for up to 17 cycles. Main eligibility requirements were a functional Eastern Cooperative Oncology Group status of 0–2, measurable or assessable disease, and no active autoimmune disease. Prior T-cell checkpoint antibody therapy was permitted.ResultsObjective response was observed in 50% of MM (7/14) and and 33% of HNSCC (2/6) patients. Belapectin+pembrolizumab was associated with fewer immune-mediated adverse events than anticipated with pembrolizumab monotherapy. There were no dose-limiting toxicities for belapectin within the dose range investigated. Significantly increased effector memory T-cell activation and reduced monocytic myeloid-derived suppressor cells (M-MDSCs) were observed in responders compared with non-responders. Increased baseline expression of Gal-3+ tumor cells and PD-1+CD8+ T cells in the periphery correlated with response as did higher serum trough levels of pembrolizumab.ConclusionsBelapectin+pembrolizumab therapy has activity in MM and HNSCC. Increased Gal-3 expression, expansion of effector memory T cells, and decreased M-MDSCs correlated with clinical response. Further investigation is planned.
Published: 2021

20. Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial

Author: Ferris, Robert L, primary, Spanos, William C, additional, Leidner, Rom, additional, Gonçalves, Anthony, additional, Martens, Uwe M, additional, Kyi, Chrisann, additional, Sharfman, William, additional, Chung, Christine H, additional, Devriese, Lot A, additional, Gauthier, Helene, additional, Chiosea, Simon I, additional, Vujanovic, Lazar, additional, Taube, Janis M, additional, Stein, Julie E, additional, Li, Jun, additional, Li, Bin, additional, Chen, Tian, additional, Barrows, Adam, additional, and Topalian, Suzanne L, additional
Published: 2021
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21. Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma

Author: Leidner, Rom, primary, Crittenden, Marka, additional, Young, Kristina, additional, Xiao, Hong, additional, Wu, Yaping, additional, Couey, Marcus A, additional, Patel, Ashish A, additional, Cheng, Allen C, additional, Watters, Amber L, additional, Bifulco, Carlo, additional, Morris, George, additional, Rushforth, Lessli, additional, Nemeth, Shorin, additional, Urba, Walter J, additional, Gough, Michael, additional, and Bell, R Bryan, additional
Published: 2021
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22. Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

Author: Curti, Brendan D, primary, Koguchi, Yoshinobu, additional, Leidner, Rom S, additional, Rolig, Annah S, additional, Sturgill, Elizabeth R, additional, Sun, Zhaoyu, additional, Wu, Yaping, additional, Rajamanickam, Venkatesh, additional, Bernard, Brady, additional, Hilgart-Martiszus, Ian, additional, Fountain, Christopher B, additional, Morris, George, additional, Iwamoto, Noriko, additional, Shimada, Takashi, additional, Chang, ShuChing, additional, Traber, Peter G, additional, Zomer, Eliezer, additional, Horton, J Rex, additional, Shlevin, Harold, additional, and Redmond, William L, additional
Published: 2021
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23. 443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response

Author: Fox, Bernard, primary, Moudgil, Tarsem, additional, Hilton, Traci, additional, Iwamoto, Noriko, additional, Paustian, Christopher, additional, Mehta, Adi, additional, Lund-Johansen, Fridtjof, additional, Sanborn, Rachel, additional, Bell, Bryan, additional, Laws, Madeleine, additional, McDonnell, Glenna, additional, Koguchi, Yoshinobu, additional, Bifulco, Carlo, additional, Piening, Brian, additional, Merino, Carmen Ballesteros, additional, Jensen, Shawn, additional, Shimada, Takashi, additional, Hu, Hong-Ming, additional, Urba, Walter, additional, Leidner, Rom, additional, and Couey, Marcus, additional
Published: 2020
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24. 386 Phase I/Ib first-in-human study of HEK-NIZ985, a recombinant IL-15/IL-15Rα heterodimer, alone and in combination with spartalizumab, in adults with advanced and metastatic solid tumors

Author: Leidner, Rom, primary, Wang-Gillam, Andrea, additional, Gupta, Sumati, additional, Wesolowski, Robert, additional, McNeel, Douglas, additional, Conlon, Kevin, additional, Parikh, Nehal, additional, O’Keeffe, Jessica, additional, Chowdhury, Niladri Roy, additional, Wang, Xiaoli, additional, Sullivan, Ryan, additional, and Thompson, John, additional
Published: 2020
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25. New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016

Author: Thomas Davis, Patrick Soon-Shiong, Edward Cha, Prasad S. Adusumilli, Jane L. Grogan, Charles G. Drake, Adi Diab, Rom Leidner, Adrian Bot, Gordon J. Freeman, Bryan Irving, Salil Patel, Ramy Ibrahim, Daniel S. Chen, David Tuck, Elizabeth E. Evans, Shane A. Olwill, Mark Cornfeld, Thomas W. Dubensky, Frédéric Triebel, and Roger D. Dansey
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Immune checkpoint inhibitors, Immunology, Alternative medicine, Review, Cancer Vaccines, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Cancer immunotherapy, Neoplasms, PD-1, Tumor Microenvironment, medicine, Humans, Immunology and Allergy, Combination therapy, Cancer, Panel discussion, Pharmacology, business.industry, Immunotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Family medicine, Molecular Medicine, business, Checkpoint inhibitors
Abstract: This report is a summary of ‘New Cancer Immunotherapy Agents in Development’ program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland. Presenters gave brief overviews of emerging clinical and pre-clinical immune-based agents and combinations, before participating in an extended panel discussion with multidisciplinary leaders, including members of the FDA, leading academic institutions and industrial drug developers, to consider topics relevant to the future of cancer immunotherapy.
Published: 2017

26. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Author: Sonja Althammer, Keith Steele, Marlon Rebelatto, Tze Heng Tan, Tobias Wiestler, Guenter Schmidt, Brandon Higgs, Xia Li, Li Shi, Xiaoping Jin, Joyce Antal, Ashok Gupta, Koustubh Ranade, Gerd Binning, Joaquim Bellmunt, Ronald de Wit, David J. Vaughn, Yves Fradet, Jae Lyun Lee, Lawrence Fong, Nicholas J. Vogelzang, Miguel A. Climent, Daniel P. Petrylak, Toni K. Choueiri, Andrea Necchi, Winald Gerritsen, Howard Gurney, David I. Quinn, Stéphane Culine, Cora N. Sternberg, Yabing Mai, Markus Puhlmann, Rodolfo F. Perini, Dean F. Bajorin, Padmanee Sharma, Margaret K. Callahan, Emiliano Calvo, Joseph W. Kim, Filipo de Braud, Patrick A. Ott, Petri Bono, Rathi N. Pillai, Michael Morse, Dung T. Le, Matthew Taylor, Pavlina Spilliopoulou, Johanna Bendell, Dirk Jaeger, Emily Chan, Scott J. Antonia, Paolo A. Ascierto, Delphine Hennicken, Marina Tschaika, Alex Azrilevich, Jonathan Rosenberg, Ofer Levy, Christopher Chan, Gady Cojocaru, Spencer Liang, Eran Ophir, Sudipto Ganguly, Amir Toporik, Maya Kotturi, Tal Fridman Kfir, Benjamin M. Murter, Kathryn Logronio, Liat Dassa, Ling Leung, Shirley Greenwald, Meir Azulay, Sandeep Kumar, Zoya Alteber, Xiaoyu Pan, Arthur Machlenkin, Yair Benita, Andrew W. Drake, Ayelet Chajut, Ran Salomon, Ilan Vankin, Einav Safyon, John Hunter, Zurit Levine, Mark White, Rom Leidner, Hyunseok Kang, Robert Haddad, Neil H. Segal, Lori J. Wirth, Robert L. Ferris, F. Stephen Hodi, Rachel E. Sanborn, Thomas F. Gajewski, William Sharfman, Dan McDonald, Shivani Srivastava, Xuemin Gu, Penny Phillips, Chaitali Passey, Tanguy Seiwert, Tsadik Habtetsion, Gang Zhou, Donastas Sakellariou-Thompson, Cara Haymaker, Caitlin Creasy, Mark Hurd, Naohiro Uraoka, Jaime Rodriguez Canales, Scott Koptez, Patrick Hwu, Anirban Maitra, Chantale Bernatchez, Scott M. Coyle, Kole T. Roybel, Levi J. Rupp, Stephen P. Santoro, Stephanie Secrest, Michael Spelman, Hanson Ho, Tina Gomes, Tiffany Tse, Chia Yung-Wu, Jack Taunton, Wendell Lim, Peter Emtage, Tarsem Moudgil, Carmen Ballesteros-Merino, Traci Hilton, Christopher Paustian, David Page, Walter Urba, Bernard Fox, Bryan Bell, Ashish Patel, Tove Olafsen, Daulet Satpayev, Michael Torgov, Filippo Marchioni, Jason Romero, Ziyue Karen Jiang, Charles Zamilpa, Jennifer S. Keppler, Alessandro Mascioni, Fang Jia, Chen-Yu Lee, Jean Gudas, Ryan J. Sullivan, Yujin Hoshida, Theodore Logan, Nikhil Khushalani, Anita Giobbie-Hurder, Kim Margolin, Joanna Roder, Rupal Bhatt, Henry Koon, Thomas Olencki, Thomas Hutson, Brendan Curti, Shauna Blackmon, James W. Mier, Igor Puzanov, Heinrich Roder, John Stewart, Asim Amin, Marc S. Ernstoff, Joseph I. Clark, Michael B. Atkins, Howard L. Kaufman, Jeffrey Sosman, Sabina Signoretti, David F. McDermott, Abraham A. Anderson, Mohammed M. Milhem, Robert H. I. Andtbacka, David Minor, Kevin S. Gorski, Daniel M. Baker, Omid Hamid, Emmanuel Akporiaye, Yoshinobu Koguchi, Kim Sutcliffe, Kristie Conder, Thomas Marron, Nina Bhardwaj, Linda Hammerich, Fiby George, Seunghee Kim-Schulze, Tibor Keler, Tom Davis, Elizabeth Crowley, Andres Salazar, Joshua Brody, Arta Monjazeb, Megan E. Daly, Jonathan Riess, Tianhong Li, William J. Murphy, Karen Kelly, Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth McMichael, Lianbo Yu, Bhuvaneswari Ramaswam, Cheryl A. London, Tian Xu, William Carson, Kathleen M. Kokolus, Elizabeth A. Repasky, Todd D. Schell, Joseph D. Drabick, David J. Messenheimer, Shawn Jensen, Mark Rubinstein, Kristina Andrijauskaite, Marzena Swiderska-syn, Kristin Lind, Agnes Choppin, Marina K. Roell, John Wrangle, Peter Rhode, Hing Wong, Shamim Ahmad, Mason Webb, Rasha Abu-Eid, Rajeev Shrimali, Vivek Verma, Atbin Doroodchi, Zuzana Berrong, David Yashar, Raed Samara, Mikayel Mkrtichyan, Samir Khleif, Steven Powell, Mark Gitau, Christopher Sumey, Andrew Terrell, Michele Lohr, Ryan K. Nowak, Steven McGraw, Ash Jensen, Miran Blanchard, Kathryn A. Gold, Ezra E. W. Cohen, Christie Ellison, Lora Black, John Lee, William Chad Spanos, Erik Wennerberg, Emily Schwitzer, Claire Lhuillier, Graeme Koelwyn, Rebecca Hiner, Lee Jones, Sandra Demaria, Vandeveer Amanda, John W. Greiner, Jeffrey Schlom, Michelle Bookstaver, Christopher M. Jewell, Andrew Gunderson, Brian Boulmay, Rui Li, Bradley Spieler, Kyle Happel, Zipei Feng, Christopher Dubay, Brenda Fisher, Sandra Aung, Eileen Mederos, Carlo B. Bifulco, Michael McNamara, Keith Bahjat, William Redmond, Augusto Ochoa, Hong-Ming Hu, Adi Mehta, Fridtjof Lund-Johansen, Frank Bedu-Addo, Greg Conn, Michael King, Panna Dutta, Robert Shepard, Mark Einstein, Sylvia Adams, Ena Wang, Ping Jin, Yelena Novik, Debra Morrison, Ruth Oratz, Franco M. Marincola, David Stroncek, Judith Goldberg, Silvia C. Formenti, Jérôme Galon, Bernhard Mlecnik, Florence Marliot, Fang-Shu Ou, Alessandro Lugli, Inti Zlobec, Tilman T. Rau, Iris D. Nagtegaal, Elisa Vink-Borger, Arndt Hartmann, Carol Geppert, Michael H. Roehrl, Prashant Bavi, Pamela S. Ohashi, Julia Y. Wang, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradley G. Wouters, Yutaka Kawakami, Boryana Papivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Kyogo Itoh, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Marc Van den Eynde, Anne Jouret-Mourin, Jean-Pascal Machiels, Tessa Fredriksen, Lucie Lafontaine, Bénédicte Buttard, Sarah Church, Pauline Maby, Helen Angell, Mihaela Angelova, Angela Vasaturo, Gabriela Bindea, Anne Berger, Christine Lagorce, Prabhu S. Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Giuseppe V. Masucci, Emilia K. Andersson, Fabio Grizzi, Luigi Laghi, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Cilberto, Franco Marincola, Daniel J. Sargent, Bernard A. Fox, Alain Algazi, Katy Tsai, Michael Rosenblum, Prachi Nandoskar, Amy Li, John Nonomura, Kathryn Takamura, Mary Dwyer, Erica Browning, Reneta Talia, Chris Twitty, Sharron Gargosky, Jean Campbell, Mai Le, Robert H. Pierce, Adil Daud, Robyn Gartrell, Douglas Marks, Edward Stack, Yan Lu, Daisuke Izaki, Kristen Beck, Dan Tong Jia, Paul Armenta, Ashley White-Stern, Yichun Fu, Zoe Blake, Bret Taback, Basil Horst, Yvonne M. Saenger, Steven Leonardo, Keith Gorden, Ross B. Fulton, Kathryn Fraser, Takashi O. Kangas, Richard Walsh, Kathleen Ertelt, Jeremy Graff, Mark Uhlik, Jennifer S. Sims, Liang Lei, Takashi Tsujiuchi, Jeffrey N. Bruce, Peter Canoll, Anthony W Tolcher, Evan W Alley, Gurunadh Chichili, Jan E Canoll, Paul Moore, Ezio Bonvini, Syd Johnson, Sadhna Shankar, James Vasselli, Jon Wigginton, and John Powderly
Subjects: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Durvalumab, medicine.medical_treatment, Immunology, Improved survival, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Immunology and Allergy, Pharmacology, business.industry, Cancer, Immunotherapy, medicine.disease, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Non small cell, business
Abstract: O1 Combinatorial CD8+ and PD-L1+ cell densities correlate with response and improved survival in non-small cell lung cancer (NSCLC) patients treated with durvalumab #### Sonja Althammer1, Keith Steele2, Marlon Rebelatto2, Tze Heng Tan1, Tobias Wiestler1, Guenter Schmidt1, Brandon Higgs2, Xia
Published: 2016

27. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Author: Casey Ager, Matthew Reilley, Courtney Nicholas, Todd Bartkowiak, Ashvin Jaiswal, Michael Curran, Tina C. Albershardt, Anshika Bajaj, Jacob F. Archer, Rebecca S. Reeves, Lisa Y. Ngo, Peter Berglund, Jan ter Meulen, Caroline Denis, Hormas Ghadially, Thomas Arnoux, Fabien Chanuc, Nicolas Fuseri, Robert W. Wilkinson, Nicolai Wagtmann, Yannis Morel, Pascale Andre, Michael B. Atkins, Matteo S. Carlino, Antoni Ribas, John A. Thompson, Toni K. Choueiri, F. Stephen Hodi, Wen-Jen Hwu, David F. McDermott, Victoria Atkinson, Jonathan S. Cebon, Bernie Fitzharris, Michael B. Jameson, Catriona McNeil, Andrew G. Hill, Eric Mangin, Malidi Ahamadi, Marianne van Vugt, Mariëlle van Zutphen, Nageatte Ibrahim, Georgina V. Long, Robyn Gartrell, Zoe Blake, Ines Simoes, Yichun Fu, Takuro Saito, Yingzhi Qian, Yan Lu, Yvonne M. Saenger, Sadna Budhu, Olivier De Henau, Roberta Zappasodi, Kyle Schlunegger, Bruce Freimark, Jeff Hutchins, Christopher A. Barker, Jedd D. Wolchok, Taha Merghoub, Elena Burova, Omaira Allbritton, Peter Hong, Jie Dai, Jerry Pei, Matt Liu, Joel Kantrowitz, Venus Lai, William Poueymirou, Douglas MacDonald, Ella Ioffe, Markus Mohrs, William Olson, Gavin Thurston, Cristian Capasso, Federica Frascaro, Sara Carpi, Siri Tähtinen, Sara Feola, Manlio Fusciello, Karita Peltonen, Beatriz Martins, Madeleine Sjöberg, Sari Pesonen, Tuuli Ranki, Lukasz Kyruk, Erkko Ylösmäki, Vincenzo Cerullo, Fabio Cerignoli, Biao Xi, Garret Guenther, Naichen Yu, Lincoln Muir, Leyna Zhao, Yama Abassi, Víctor Cervera-Carrascón, Mikko Siurala, João Santos, Riikka Havunen, Suvi Parviainen, Akseli Hemminki, Angus Dalgleish, Satvinder Mudan, Mark DeBenedette, Ana Plachco, Alicia Gamble, Elizabeth W. Grogan, John Krisko, Irina Tcherepanova, Charles Nicolette, Pooja Dhupkar, Ling Yu, Eugenie S. Kleinerman, Nancy Gordon, Italia Grenga, Lauren Lepone, Sofia Gameiro, Karin M. Knudson, Massimo Fantini, Kwong Tsang, James Hodge, Renee Donahue, Jeffrey Schlom, Elizabeth Evans, Holm Bussler, Crystal Mallow, Christine Reilly, Sebold Torno, Maria Scrivens, Cathie Foster, Alan Howell, Leslie Balch, Alyssa Knapp, John E. Leonard, Mark Paris, Terry Fisher, Siwen Hu-Lieskovan, Ernest Smith, Maurice Zauderer, William Fogler, Marilyn Franklin, Matt Thayer, Dan Saims, John L. Magnani, Jian Gong, Michael Gray, George Fromm, Suresh de Silva, Louise Giffin, Xin Xu, Jason Rose, Taylor H. Schreiber, Sofia R. Gameiro, Paul E. Clavijo, Clint T. Allen, James W. Hodge, Kwong Y. Tsang, Jane Grogan, Nicholas Manieri, Eugene Chiang, Patrick Caplazi, Mahesh Yadav, Patrick Hagner, Hsiling Chiu, Michelle Waldman, Anke Klippel, Anjan Thakurta, Michael Pourdehnad, Anita Gandhi, Ian Henrich, Laura Quick, Rob Young, Margaret Chou, Andrew Hotson, Stephen Willingham, Po Ho, Carmen Choy, Ginna Laport, Ian McCaffery, Richard Miller, Kimberly A. Tipton, Kenneth R. Wong, Victoria Singson, Chihunt Wong, Chanty Chan, Yuanhiu Huang, Shouchun Liu, Jennifer H. Richardson, W. Michael Kavanaugh, James West, Bryan A. Irving, Ritika Jaini, Matthew Loya, Charis Eng, Melissa L. Johnson, Alex A. Adjei, Mateusz Opyrchal, Suresh Ramalingam, Pasi A. Janne, George Dominguez, Dmitry Gabrilovich, Laura de Leon, Jeannette Hasapidis, Scott J. Diede, Peter Ordentlich, Scott Cruickshank, Michael L. Meyers, Matthew D. Hellmann, Pawel Kalinski, Amer Zureikat, Robert Edwards, Ravi Muthuswamy, Nataša Obermajer, Julie Urban, Lisa H. Butterfield, William Gooding, Herbert Zeh, David Bartlett, Olga Zubkova, Larissa Agapova, Marina Kapralova, Liudmila Krasovskaia, Armen Ovsepyan, Maxim Lykov, Artem Eremeev, Vladimir Bokovanov, Olga Grigoryeva, Andrey Karpov, Sergey Ruchko, Alexandr Shuster, Danny N. Khalil, Luis Felipe Campesato, Yanyun Li, Adam S. Lazorchak, Troy D. Patterson, Yueyun Ding, Pottayil Sasikumar, Naremaddepalli Sudarshan, Nagaraj Gowda, Raghuveer Ramachandra, Dodheri Samiulla, Sanjeev Giri, Rajesh Eswarappa, Murali Ramachandra, David Tuck, Timothy Wyant, Jasmin Leshem, Xiu-fen Liu, Tapan Bera, Masaki Terabe, Birgit Bossenmaier, Gerhard Niederfellner, Yoram Reiter, Ira Pastan, Leiming Xia, Yang Xia, Yangyang Hu, Yi Wang, Yangyi Bao, Fu Dai, Shiang Huang, Elaine Hurt, Robert E. Hollingsworth, Lawrence G. Lum, Alfred E. Chang, Max S. Wicha, Qiao Li, Thomas Mace, Neil Makhijani, Erin Talbert, Gregory Young, Denis Guttridge, Darwin Conwell, Gregory B. Lesinski, Rodney JM Macedo Gonzales, Austin P. Huffman, Ximi K. Wang, Ran Reshef, Andy MacKinnon, Jason Chen, Matt Gross, Gisele Marguier, Peter Shwonek, Natalija Sotirovska, Susanne Steggerda, Francesco Parlati, Amani Makkouk, Mark K. Bennett, Ethan Emberley, Tony Huang, Weiqun Li, Silinda Neou, Alison Pan, Jing Zhang, Winter Zhang, Netonia Marshall, Thomas U. Marron, Judith Agudo, Brian Brown, Joshua Brody, Christopher McQuinn, Matthew Farren, Hannah Komar, Reena Shakya, Thomas Ludwug, Y. Maurice Morillon, Scott A. Hammond, John W. Greiner, Pulak R. Nath, Anthony L. Schwartz, Dragan Maric, David D. Roberts, Aung Naing, Kyriakos P. Papadopoulos, Karen A. Autio, Deborah J. Wong, Manish Patel, Gerald Falchook, Shubham Pant, Patrick A. Ott, Melinda Whiteside, Amita Patnaik, John Mumm, Filip Janku, Ivan Chan, Todd Bauer, Rivka Colen, Peter VanVlasselaer, Gail L. Brown, Nizar M. Tannir, Martin Oft, Jeffrey Infante, Evan Lipson, Ajay Gopal, Sattva S. Neelapu, Philippe Armand, Stephen Spurgeon, John P. Leonard, Rachel E. Sanborn, Ignacio Melero, Thomas F. Gajewski, Matthew Maurer, Serena Perna, Andres A. Gutierrez, Raphael Clynes, Priyam Mitra, Satyendra Suryawanshi, Douglas Gladstone, Margaret K. Callahan, James Crooks, Sheila Brown, Audrey Gauthier, Marc Hillairet de Boisferon, Andrew MacDonald, Laura Rosa Brunet, William T. Rothwell, Peter Bell, James M. Wilson, Fumi Sato-Kaneko, Shiyin Yao, Shannon S. Zhang, Dennis A. Carson, Cristina Guiducci, Robert L. Coffman, Kazutaka Kitaura, Takaji Matsutani, Ryuji Suzuki, Tomoko Hayashi, Ezra E. W. Cohen, David Schaer, Yanxia Li, Julie Dobkin, Michael Amatulli, Gerald Hall, Thompson Doman, Jason Manro, Frank Charles Dorsey, Lillian Sams, Rikke Holmgaard, Krishnadatt Persaud, Dale Ludwig, David Surguladze, John S. Kauh, Ruslan Novosiadly, Michael Kalos, Kyla Driscoll, Hardev Pandha, Christy Ralph, Kevin Harrington, Brendan Curti, Wallace Akerley, Sumati Gupta, Alan Melcher, David Mansfield, David R. Kaufman, Emmett Schmidt, Mark Grose, Bronwyn Davies, Roberta Karpathy, Darren Shafren, Katerina Shamalov, Cyrille Cohen, Naveen Sharma, James Allison, Tala Shekarian, Sandrine Valsesia-Wittmann, Christophe Caux, Aurelien Marabelle, Brian M. Slomovitz, Kathleen M. Moore, Hagop Youssoufian, Marshall Posner, Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, Kithsiri Wijeratne, Leslie A. A. Gunatilaka, Thomas J. Sayers, John P. Vasilakos, Tesha Alston, Simon Dovedi, James Elvecrog, Iwen Grigsby, Ronald Herbst, Karen Johnson, Craig Moeckly, Stefanie Mullins, Kristen Siebenaler, Julius SternJohn, Ashenafi Tilahun, Mark A. Tomai, Katharina Vogel, Eveline E. Vietsch, Anton Wellstein, Martin Wythes, Stefano Crosignani, Joseph Tumang, Shilpa Alekar, Patrick Bingham, Sandra Cauwenberghs, Jenny Chaplin, Deepak Dalvie, Sofie Denies, Coraline De Maeseneire, JunLi Feng, Kim Frederix, Samantha Greasley, Jie Guo, James Hardwick, Stephen Kaiser, Katti Jessen, Erick Kindt, Marie-Claire Letellier, Wenlin Li, Karen Maegley, Reece Marillier, Nichol Miller, Brion Murray, Romain Pirson, Julie Preillon, Virginie Rabolli, Chad Ray, Kevin Ryan, Stephanie Scales, Jay Srirangam, Jim Solowiej, Al Stewart, Nicole Streiner, Vince Torti, Konstantinos Tsaparikos, Xianxian Zheng, Gregory Driessens, Bruno Gomes, Manfred Kraus, Chunxiao Xu, Yanping Zhang, Giorgio Kradjian, Guozhong Qin, Jin Qi, Xiaomei Xu, Bo Marelli, Huakui Yu, Wilson Guzman, Rober Tighe, Rachel Salazar, Kin-Ming Lo, Jessie English, Laszlo Radvanyi, Yan Lan, Michael Postow, Yasin Senbabaoglu, Billel Gasmi, Hong Zhong, Cailian Liu, Daniel Hirschhorhn-Cymerman, Yuanyuan Zha, Gregory Malnassy, Noreen Fulton, Jae-Hyun Park, Wendy Stock, Yusuke Nakamura, Hongtao Liu, Xiaoming Ju, Rachelle Kosoff, Kimberly Ramos, Brandon Coder, Robert Petit, Michael Princiotta, Kyle Perry, Jun Zou, Ainhoa Arina, Christian Fernandez, Wenxin Zheng, Michael A. Beckett, Helena J. Mauceri, Yang-Xin Fu, Ralph R. Weichselbaum, Whitney Lewis, Yanyan Han, Yeting Wu, Chou Yang, Jing Huang, Dongyun Wu, Jin Li, Xiaoling Liang, Xiangjun Zhou, Jinlin Hou, Raffit Hassan, Thierry Jahan, Scott J. Antonia, Hedy L. Kindler, Evan W. Alley, Somayeh Honarmand, Weiqun Liu, Meredith L. Leong, Chan C. Whiting, Nitya Nair, Amanda Enstrom, Edward E. Lemmens, Takahiro Tsujikawa, Sushil Kumar, Lisa M. Coussens, Aimee L. Murphy, Dirk G. Brockstedt, Sven D. Koch, Martin Sebastian, Christian Weiss, Martin Früh, Miklos Pless, Richard Cathomas, Wolfgang Hilbe, Georg Pall, Thomas Wehler, Jürgen Alt, Helge Bischoff, Michael Geissler, Frank Griesinger, Jens Kollmeier, Alexandros Papachristofilou, Fatma Doener, Mariola Fotin-Mleczek, Madeleine Hipp, Henoch S. Hong, Karl-Josef Kallen, Ute Klinkhardt, Claudia Stosnach, Birgit Scheel, Andreas Schroeder, Tobias Seibel, Ulrike Gnad-Vogt, Alfred Zippelius, Ha-Ram Park, Yong-Oon Ahn, Tae Min Kim, Soyeon Kim, Seulki Kim, Yu Soo Lee, Bhumsuk Keam, Dong-Wan Kim, Dae Seog Heo, Shari Pilon-Thomas, Amy Weber, Jennifer Morse, Krithika Kodumudi, Hao Liu, John Mullinax, Amod A. Sarnaik, Luke Pike, Andrew Bang, Tracy Balboni, Allison Taylor, Alexander Spektor, Tyler Wilhite, Monica Krishnan, Daniel Cagney, Brian Alexander, Ayal Aizer, Elizabeth Buchbinder, Mark Awad, Leena Ghandi, Jonathan Schoenfeld, Elizabeth Lessey-Morillon, Lisa Ridnour, Neil H. Segal, Manish Sharma, Dung T. Le, Robert L. Ferris, Andrew D. Zelenetz, Ronald Levy, Izidore S. Lossos, Caron Jacobson, Radhakrishnan Ramchandren, John Godwin, A. Dimitrios Colevas, Roland Meier, Suba Krishnan, Xuemin Gu, Jaclyn Neely, John Timmerman, Claire I. Vanpouille-Box, Silvia C. Formenti, Sandra Demaria, Erik Wennerberg, Aranzazu Mediero, Bruce N. Cronstein, Michael P. Gustafson, AriCeli DiCostanzo, Courtney Wheatley, Chul-Ho Kim, Svetlana Bornschlegl, Dennis A. Gastineau, Bruce D. Johnson, Allan B. Dietz, Cameron MacDonald, Mark Bucsek, Guanxi Qiao, Bonnie Hylander, Elizabeth Repasky, William J. Turbitt, Yitong Xu, Andrea Mastro, Connie J. Rogers, Sita Withers, Ziming Wang, Lam T. Khuat, Cordelia Dunai, Bruce R. Blazar, Dan Longo, Robert Rebhun, Steven K. Grossenbacher, Arta Monjazeb, William J. Murphy, Scott Rowlinson, Giulia Agnello, Susan Alters, David Lowe, Nicole Scharping, Ashley V. Menk, Ryan Whetstone, Xue Zeng, Greg M. Delgoffe, Patricia M. Santos, Jian Shi, Greg Delgoffe, Misako Nagasaka, Ammar Sukari, Miranda Byrne-Steele, Wenjing Pan, Xiaohong Hou, Brittany Brown, Mary Eisenhower, Jian Han, Natalie Collins, Robert Manguso, Hans Pope, Yashaswi Shrestha, Jesse Boehm, W. Nicholas Haining, Kyle R. Cron, Ayelet Sivan, Keston Aquino-Michaels, Marco Orecchioni, Davide Bedognetti, Wouter Hendrickx, Claudia Fuoco, Filomena Spada, Francesco Sgarrella, Gianni Cesareni, Francesco Marincola, Kostas Kostarelos, Alberto Bianco, Lucia Delogu, Jessica Roelands, Sabri Boughorbel, Julie Decock, Scott Presnell, Ena Wang, Franco M. Marincola, Peter Kuppen, Michele Ceccarelli, Darawan Rinchai, Damien Chaussabel, Lance Miller, Andrew Nguyen, J. Zachary Sanborn, Charles Vaske, Shahrooz Rabizadeh, Kayvan Niazi, Steven Benz, Shashank Patel, Nicholas Restifo, James White, Sam Angiuoli, Mark Sausen, Sian Jones, Maria Sevdali, John Simmons, Victor Velculescu, Luis Diaz, Theresa Zhang, Jennifer S. Sims, Sunjay M. Barton, Angela Kadenhe-Chiweshe, Filemon Dela Cruz, Andrew T. Turk, Christopher F. Mazzeo, Andrew L. Kung, Jeffrey N. Bruce, Darrell J. Yamashiro, Eileen P. Connolly, Jason Baird, Marka Crittenden, David Friedman, Hong Xiao, Rom Leidner, Bryan Bell, Kristina Young, Michael Gough, Zhen Bian, Koby Kidder, Yuan Liu, Emily Curran, Xiufen Chen, Leticia P. Corrales, Justin Kline, Ethan G. Aguilar, Jennifer Guerriero, Alaba Sotayo, Holly Ponichtera, Alexandra Pourzia, Sara Schad, Ruben Carrasco, Suzan Lazo, Roderick Bronson, Anthony Letai, Richard S. Kornbluth, Sachin Gupta, James Termini, Elizabeth Guirado, Geoffrey W. Stone, Christina Meyer, Laura Helming, Nicholas Wilson, Robert Hofmeister, Natalie J. Neubert, Laure Tillé, David Barras, Charlotte Soneson, Petra Baumgaertner, Donata Rimoldi, David Gfeller, Mauro Delorenzi, Silvia A. Fuertes Marraco, Daniel E. Speiser, Tara S. Abraham, Bo Xiang, Michael S. Magee, Scott A. Waldman, Adam E. Snook, Wojciech Blogowski, Ewa Zuba-Surma, Marta Budkowska, Daria Salata, Barbara Dolegowska, Teresa Starzynska, Leo Chan, Srinivas Somanchi, Kelsey McCulley, Dean Lee, Nico Buettner, Feng Shi, Paisley T. Myers, Stuart Curbishley, Sarah A. Penny, Lora Steadman, David Millar, Ellen Speers, Nicola Ruth, Gabriel Wong, Robert Thimme, David Adams, Mark Cobbold, Remy Thomas, Mariam Al-Muftah, Michael KK Wong, Michael Morse, Joseph I. Clark, Howard L. Kaufman, Gregory A. Daniels, Hong Hua, Tharak Rao, Janice P. Dutcher, Kai Kang, Yogen Saunthararajah, Vamsidhar Velcheti, Vikas Kumar, Firoz Anwar, Amita Verma, Zinal Chheda, Gary Kohanbash, John Sidney, Kaori Okada, Shruti Shrivastav, Diego A. Carrera, Shuming Liu, Naznin Jahan, Sabine Mueller, Ian F. Pollack, Angel M. Carcaboso, Alessandro Sette, Yafei Hou, Hideho Okada, Jessica J. Field, Weiping Zeng, Vincent FS Shih, Che-Leung Law, Peter D. Senter, Shyra J. Gardai, Nicole M. Okeley, Jennifer G. Abelin, Abu Z. Saeed, Stacy A. Malaker, Jeffrey Shabanowitz, Stephen T. Ward, Donald F. Hunt, Pam Profusek, Laura Wood, Dale Shepard, Petros Grivas, Kerstin Kapp, Barbara Volz, Detlef Oswald, Burghardt Wittig, Manuel Schmidt, Julian P. Sefrin, Lars Hillringhaus, Valeria Lifke, Alexander Lifke, Anna Skaletskaya, Jose Ponte, Thomas Chittenden, Yulius Setiady, Eva Sivado, Vincent Thomas, Meddy El Alaoui, Sébastien Papot, Charles Dumontet, Mike Dyson, John McCafferty, Said El Alaoui, Praveen K. Bommareddy, Andrew Zloza, Frederick Kohlhapp, Ann W. Silk, Sachin Jhawar, Tomas Paneque, Jenna Newman, Pedro Beltran, Felicia Cao, Bang-Xing Hong, Tania Rodriguez-Cruz, Xiao-Tong Song, Stephen Gottschalk, Hugo Calderon, Sam Illingworth, Alice Brown, Kerry Fisher, Len Seymour, Brian Champion, Emma Eriksson, Jessica Wenthe, Ann-Charlotte Hellström, Gabriella Paul-Wetterberg, Angelica Loskog, Ioanna Milenova, Magnus Ståhle, Justyna Jarblad-Leja, Gustav Ullenhag, Anna Dimberg, Rafael Moreno, Ramon Alemany, Sharad Goyal, Ann Silk, Janice Mehnert, Nashat Gabrail, Jennifer Bryan, Daniel Medina, Leah Mitchell, Kader Yagiz, Fernando Lopez, Daniel Mendoza, Anthony Munday, Harry Gruber, Douglas Jolly, Steven Fuhrmann, Sasa Radoja, Wei Tan, Aldo Pourchet, Alan Frey, Ian Mohr, Matthew Mulvey, Robert H. I. Andtbacka, Merrick Ross, Sanjiv Agarwala, Kenneth Grossmann, Matthew Taylor, John Vetto, Rogerio Neves, Adil Daud, Hung Khong, Stephanie M. Meek, Richard Ungerleider, Scott Welden, Maki Tanaka, Matthew Williams, Sigrun Hallmeyer, Bernard Fox, Zipei Feng, Christopher Paustian, Carlo Bifulco, Sadia Zafar, Otto Hemminki, Simona Bramante, Lotta Vassilev, Hongjie Wang, Andre Lieber, Silvio Hemmi, Tanja de Gruijl, Anna Kanerva, Tameem Ansari, Srividya Sundararaman, Diana Roen, Paul Lehmann, Anja C. Bloom, Lewis H. Bender, Ian B. Walters, Jay A. Berzofsky, Fanny Chapelin, Eric T. Ahrens, Jeff DeFalco, Michael Harbell, Amy Manning-Bog, Alexander Scholz, Danhui Zhang, Gilson Baia, Yann Chong Tan, Jeremy Sokolove, Dongkyoon Kim, Kevin Williamson, Xiaomu Chen, Jillian Colrain, Gregg Espiritu Santo, Ngan Nguyen, Wayne Volkmuth, Norman Greenberg, William Robinson, Daniel Emerling, Charles G. Drake, Daniel P. Petrylak, Emmanuel S. Antonarakis, Adam S. Kibel, Nancy N. Chang, Tuyen Vu, Dwayne Campogan, Heather Haynes, James B. Trager, Nadeem A. Sheikh, David I. Quinn, Peter Kirk, Murali Addepalli, Thomas Chang, Ping Zhang, Marina Konakova, Katsunobu Hagihara, Steven Pai, Laurie VanderVeen, Palakshi Obalapur, Peiwen Kuo, Phi Quach, Lawrence Fong, Deborah H. Charych, Jonathan Zalevsky, John L. Langowski, Yolanda Kirksey, Ravi Nutakki, Shalini Kolarkar, Rhoneil Pena, Ute Hoch, Stephen K. Doberstein, John Cha, Zach Mallon, Myra Perez, Amanda McDaniel, Snjezana Anand, Darrin Uecker, Richard Nuccitelli, Eva Wieckowski, Ravikumar Muthuswamy, Roshni Ravindranathan, Ariana N. Renrick, Menaka Thounaojam, Portia Thomas, Samuel Pellom, Anil Shanker, Duafalia Dudimah, Alan Brooks, Yu-Lin Su, Tomasz Adamus, Qifang Zhang, Sergey Nechaev, Marcin Kortylewski, Spencer Wei, Clark Anderson, Chad Tang, Jonathan Schoenhals, Efrosini Tsouko, John Heymach, Patricia de Groot, Joe Chang, Kenneth R. Hess, Adi Diab, Padmanee Sharma, David Hong, James Welsh, Andrea J. Parsons, Jardin Leleux, Stephane Ascarateil, Marie Eve Koziol, Dina Bai, Peihong Dai, Weiyi Wang, Ning Yang, Stewart Shuman, Liang Deng, Patrick Dillon, Gina Petroni, David Brenin, Kim Bullock, Walter Olson, Mark E. Smolkin, Kelly Smith, Carmel Nail, Craig L. Slingluff, Meenu Sharma, Faisal Fa’ak, Louise Janssen, Hiep Khong, Zhilan Xiao, Yared Hailemichael, Manisha Singh, Christina Vianden, Willem W. Overwijk, Andrea Facciabene, Pierini Stefano, Fang Chongyung, Stavros Rafail, Michael Nielsen, Peter Vanderslice, Darren G. Woodside, Robert V. Market, Ronald J. Biediger, Upendra K. Marathi, Kevin Hollevoet, Nick Geukens, Paul Declerck, Nathalie Joly, Laura McIntosh, Eustache Paramithiotis, Magnus Rizell, Malin Sternby, Bengt Andersson, Alex Karlsson-Parra, Rui Kuai, Lukasz Ochyl, Anna Schwendeman, James Moon, Weiwen Deng, Thomas E. Hudson, Bill Hanson, Chris S. Rae, Joel Burrill, Justin Skoble, George Katibah, Michele deVries, Peter Lauer, Thomas W. Dubensky, Xin Chen, Li Zhou, Xiubao Ren, Charu Aggarwal, Drishty Mangrolia, Roger Cohen, Gregory Weinstein, Matthew Morrow, Joshua Bauml, Kim Kraynyak, Jean Boyer, Jian Yan, Jessica Lee, Laurent Humeau, Sandra Oyola, Susan Duff, David Weiner, Zane Yang, Mark Bagarazzi, Douglas G. McNeel, Jens Eickhoff, Robert Jeraj, Mary Jane Staab, Jane Straus, Brian Rekoske, Glenn Liu, Marit Melssen, William Grosh, Nikole Varhegyi, Nadejda Galeassi, Donna H. Deacon, Elizabeth Gaughan, Maurizio Ghisoli, Minal Barve, Robert Mennel, Gladice Wallraven, Luisa Manning, Neil Senzer, John Nemunaitis, Masahiro Ogasawara, Shuichi Ota, Kaitlin M. Peace, Diane F. Hale, Timothy J. Vreeland, Doreen O. Jackson, John S. Berry, Alfred F. Trappey, Garth S. Herbert, Guy T. Clifton, Mark O. Hardin, Anne Toms, Na Qiao, Jennifer Litton, George E. Peoples, Elizabeth A. Mittendorf, Lila Ghamsari, Emilio Flano, Judy Jacques, Biao Liu, Jonathan Havel, Vladimir Makarov, Timothy A. Chan, Jessica B. Flechtner, John Facciponte, Stefano Ugel, Francesco De Sanctis, George Coukos, Sébastien Paris, Agnes Pottier, Laurent Levy, Bo Lu, Federica Cappuccini, Emily Pollock, Richard Bryant, Freddie Hamdy, Adrian Hill, Irina Redchenko, Hussein Sultan, Takumi Kumai, Valentyna Fesenkova, Esteban Celis, Ingrid Fernando, Claudia Palena, Justin M. David, Elizabeth Gabitzsch, Frank Jones, James L. Gulley, Mireia Uribe Herranz, Hiroshi Wada, Atsushi Shimizu, Toshihiro Osada, Satoshi Fukaya, Eiji Sasaki, Milad Abolhalaj, David Askmyr, Kristina Lundberg, Ann-Sofie Albrekt, Lennart Greiff, Malin Lindstedt, Dallas B. Flies, Tomoe Higuchi, Wojciech Ornatowski, Jaryse Harris, Sarah F. Adams, Todd Aguilera, Marjan Rafat, Laura Castellini, Hussein Shehade, Mihalis Kariolis, Dadi Jang, Rie vonEbyen, Edward Graves, Lesley Ellies, Erinn Rankin, Albert Koong, Amato Giaccia, Reham Ajina, Shangzi Wang, Jill Smith, Mariaelena Pierobon, Sandra Jablonski, Emanuel Petricoin, Louis M. Weiner, Lorcan Sherry, John Waller, Mark Anderson, Alison Bigley, Chantale Bernatchez, Cara Haymaker, Harriet Kluger, Michael Tetzlaff, Natalie Jackson, Ivan Gergel, Mary Tagliaferri, Patrick Hwu, Mario Snzol, Michael Hurwitz, Theresa Barberi, Allison Martin, Rahul Suresh, David Barakat, Sarah Harris-Bookman, Charles Drake, Alan Friedman, Sara Berkey, Stephanie Downs-Canner, Robert P. Edwards, Tyler Curiel, Kunle Odunsi, Tullia C. Bruno, Brandon Moore, Olivia Squalls, Peggy Ebner, Katherine Waugh, John Mitchell, Wilbur Franklin, Daniel Merrick, Martin McCarter, Brent Palmer, Jeffrey Kern, Dario Vignali, Jill Slansky, Anissa S. H. Chan, Xiaohong Qiu, Kathryn Fraser, Adria Jonas, Nadine Ottoson, Keith Gordon, Takashi O. Kangas, Steven Leonardo, Kathleen Ertelt, Richard Walsh, Mark Uhlik, Jeremy Graff, Nandita Bose, Ravi Gupta, Nitin Mandloi, Kiran Paul, Ashwini Patil, Rekha Sathian, Aparna Mohan, Malini Manoharan, Amitabha Chaudhuri, Yu Chen, Jing Lin, Yun-bin Ye, Chun-wei Xu, Gang Chen, Zeng-qing Guo, Andrey Komarov, Alex Chenchik, Michael Makhanov, Costa Frangou, Yi Zheng, Carla Coltharp, Darryn Unfricht, Ryan Dilworth, Leticia Fridman, Linying Liu, Milind Rajopadhye, Peter Miller, Fernando Concha-Benavente, Julie Bauman, Sumita Trivedi, Raghvendra Srivastava, James Ohr, Dwight Heron, Uma Duvvuri, Seungwon Kim, Heather Torrey, Toshi Mera, Yoshiaki Okubo, Eva Vanamee, Rosemary Foster, Denise Faustman, Edward Stack, Daisuke Izaki, Kristen Beck, Dan Tong Jia, Paul Armenta, Ashley White-Stern, Douglas Marks, Bret Taback, Basil Horst, Laura Hix Glickman, David B. Kanne, Kelsey S. Gauthier, Anthony L. Desbien, Brian Francica, Justin L. Leong, Leonard Sung, Ken Metchette, Shailaja Kasibhatla, Anne Marie Pferdekamper, Lianxing Zheng, Charles Cho, Yan Feng, Jeffery M. McKenna, John Tallarico, Steven Bender, Chudi Ndubaku, Sarah M. McWhirter, Elena Gonzalez Gugel, Charles J. M. Bell, Adiel Munk, Luciana Muniz, Nina Bhardwaj, Fei Zhao, Kathy Evans, Christine Xiao, Alisha Holtzhausen, Brent A. Hanks, Nathalie Scholler, Catherine Yin, Pien Van der Meijs, Andrew M. Prantner, Cecile M. Krejsa, Leia Smith, Brian Johnson, Daniel Branstetter, Paul L. Stein, Juan C. Jaen, Joanne BL Tan, Ada Chen, Timothy Park, Jay P. Powers, Holly Sexton, Guifen Xu, Steve W. Young, Ulrike Schindler, Wentao Deng, David John Klinke, Hannah M. Komar, Gregory Serpa, Omar Elnaggar, Philip Hart, Carl Schmidt, Mary Dillhoff, Ming Jin, Michael C. Ostrowski, Madhuri Koti, Katrina Au, Nichole Peterson, Peter Truesdell, Gillian Reid-Schachter, Charles Graham, Andrew Craig, Julie-Ann Francis, Beatrix Kotlan, Timea Balatoni, Emil Farkas, Laszlo Toth, Mihaly Ujhelyi, Akos Savolt, Zoltan Doleschall, Szabolcs Horvath, Klara Eles, Judit Olasz, Orsolya Csuka, Miklos Kasler, Gabriella Liszkay, Eytan Barnea, Collin Blakely, Patrick Flynn, Reid Goodman, Raphael Bueno, David Sugarbaker, David Jablons, V. Courtney Broaddus, Brian West, Paul R. Kunk, Joseph M. Obeid, Kevin Winters, Patcharin Pramoonjago, Edward B. Stelow, Todd W. Bauer, Osama E. Rahma, Adam Lamble, Yoko Kosaka, Fei Huang, Kate A. Saser, Homer Adams, Christina E. Tognon, Ted Laderas, Shannon McWeeney, Marc Loriaux, Jeffery W. Tyner, Brian J. Druker, Evan F. Lind, Zhuqing Liu, Shanhong Lu, Lawrence P. Kane, Gulidanna Shayan, Julia Femel, Ryan Lane, Jamie Booth, Amanda W. Lund, Anthony Rodriguez, Victor H. Engelhard, Alessandra Metelli, Bill X. Wu, Caroline W. Fugle, Rachidi Saleh, Shaoli Sun, Jennifer Wu, Bei Liu, Zihai Li, Zachary S. Morris, Emily I. Guy, Clinton Heinze, Jasdeep Kler, Monica M. Gressett, Lauryn R. Werner, Stephen D. Gillies, Alan J. Korman, Hans Loibner, Jacquelyn A. Hank, Alexander L. Rakhmilevich, Paul M. Harari, Paul M. Sondel, Erica Huelsmann, Joseph Broucek, Dorothee Brech, Tobias Straub, Martin Irmler, Johannes Beckers, Florian Buettner, Elke Schaeffeler, Matthias Schwab, Elfriede Noessner, Alison Wolfreys, Andre Da Costa, John Silva, Andrea Crosby, Ludovicus Staelens, Graham Craggs, Annick Cauvin, Sean Mason, Alison M. Paterson, Andrew C. Lake, Caroline M. Armet, Rachel W. O’Connor, Jonathan A. Hill, Emmanuel Normant, Ammar Adam, Detlev M. Biniszkiewicz, Scott C. Chappel, Vito J. Palombella, Pamela M. Holland, Annette Becker, Manmohan R. Leleti, Eric Newcomb, Joanne B. L. Tan, Suthee Rapisuwon, Arash Radfar, Kellie Gardner, Geoffrey Gibney, Michael Atkins, Keith R. Rennier, Robert Crowder, Ping Wang, Russell K. Pachynski, Rosa M. Santana Carrero, Sarai Rivas, Figen Beceren-Braun, Scott Anthony, Kimberly S. Schluns, Deepali Sawant, Maria Chikina, Hiroshi Yano, Creg Workman, Elise Salerno, Ileana Mauldin, Donna Deacon, Sofia Shea, Joel Pinczewski, Thomas Gajewski, Stefani Spranger, Brendan Horton, Akiko Suzuki, Pamela Leland, Bharat H. Joshi, Raj K. Puri, Randy F. Sweis, Riyue Bao, Jason Luke, Marie-Nicole Theodoraki, Frances-Mary Mogundo, Haejung Won, Dayson Moreira, Chan Gao, Xingli Zhao, Priyanka Duttagupta, Jeremy Jones, Massimo D’Apuzzo, and Sumanta Pal
Subjects: 0301 basic medicine, Pharmacology, Cancer Research, medicine.medical_specialty, business.industry, medicine.medical_treatment, Immunology, Cancer, Immunotherapy, medicine.disease, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Family medicine, Molecular Medicine, Immunology and Allergy, Medicine, business
Abstract: O1 IL-15 primes an mTOR-regulated gene-expression program to prolong anti-tumor capacity of human natural killer cells #### Andreas Lundqvist1, Vincent van Hoef1, Xiaonan Zhang1, Erik Wennerberg2, Julie Lorent1, Kristina Witt1, Laia Masvidal Sanz1, Shuo Liang1, Shannon Murray3, Ola Larsson1
Published: 2016

28. New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016

Author: Adusumilli, Prasad S., primary, Cha, Edward, additional, Cornfeld, Mark, additional, Davis, Thomas, additional, Diab, Adi, additional, Dubensky, Thomas W., additional, Evans, Elizabeth, additional, Grogan, Jane L., additional, Irving, Bryan A., additional, Leidner, Rom S., additional, Olwill, Shane A., additional, Soon-Shiong, Patrick, additional, Triebel, Frederic, additional, Tuck, David, additional, Bot, Adrian, additional, Dansey, Roger D., additional, Drake, Charles G., additional, Freeman, Gordon J., additional, Ibrahim, Ramy, additional, Patel, Salil, additional, and Chen, Daniel S., additional
Published: 2017
Full Text: View/download PDF

29. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Author: Althammer, Sonja, primary, Steele, Keith, additional, Rebelatto, Marlon, additional, Tan, Tze Heng, additional, Wiestler, Tobias, additional, Schmidt, Guenter, additional, Higgs, Brandon, additional, Li, Xia, additional, Shi, Li, additional, Jin, Xiaoping, additional, Antal, Joyce, additional, Gupta, Ashok, additional, Ranade, Koustubh, additional, Binning, Gerd, additional, Bellmunt, Joaquim, additional, de Wit, Ronald, additional, Vaughn, David J., additional, Fradet, Yves, additional, Lee, Jae Lyun, additional, Fong, Lawrence, additional, Vogelzang, Nicholas J., additional, Climent, Miguel A., additional, Petrylak, Daniel P., additional, Choueiri, Toni K., additional, Necchi, Andrea, additional, Gerritsen, Winald, additional, Gurney, Howard, additional, Quinn, David I., additional, Culine, Stéphane, additional, Sternberg, Cora N., additional, Mai, Yabing, additional, Puhlmann, Markus, additional, Perini, Rodolfo F., additional, Bajorin, Dean F., additional, Sharma, Padmanee, additional, Callahan, Margaret K., additional, Calvo, Emiliano, additional, Kim, Joseph W., additional, de Braud, Filipo, additional, Ott, Patrick A., additional, Bono, Petri, additional, Pillai, Rathi N., additional, Morse, Michael, additional, Le, Dung T., additional, Taylor, Matthew, additional, Spilliopoulou, Pavlina, additional, Bendell, Johanna, additional, Jaeger, Dirk, additional, Chan, Emily, additional, Antonia, Scott J., additional, Ascierto, Paolo A., additional, Hennicken, Delphine, additional, Tschaika, Marina, additional, Azrilevich, Alex, additional, Rosenberg, Jonathan, additional, Levy, Ofer, additional, Chan, Christopher, additional, Cojocaru, Gady, additional, Liang, Spencer, additional, Ophir, Eran, additional, Ganguly, Sudipto, additional, Toporik, Amir, additional, Kotturi, Maya, additional, Kfir, Tal Fridman, additional, Murter, Benjamin M., additional, Logronio, Kathryn, additional, Dassa, Liat, additional, Leung, Ling, additional, Greenwald, Shirley, additional, Azulay, Meir, additional, Kumar, Sandeep, additional, Alteber, Zoya, additional, Pan, Xiaoyu, additional, Machlenkin, Arthur, additional, Benita, Yair, additional, Drake, Andrew W., additional, Chajut, Ayelet, additional, Salomon, Ran, additional, Vankin, Ilan, additional, Safyon, Einav, additional, Hunter, John, additional, Levine, Zurit, additional, White, Mark, additional, Leidner, Rom, additional, Kang, Hyunseok, additional, Haddad, Robert, additional, Segal, Neil H., additional, Wirth, Lori J., additional, Ferris, Robert L., additional, Hodi, F. Stephen, additional, Sanborn, Rachel E., additional, Gajewski, Thomas F., additional, Sharfman, William, additional, McDonald, Dan, additional, Srivastava, Shivani, additional, Gu, Xuemin, additional, Phillips, Penny, additional, Passey, Chaitali, additional, Seiwert, Tanguy, additional, Habtetsion, Tsadik, additional, Zhou, Gang, additional, Sakellariou-Thompson, Donastas, additional, Haymaker, Cara, additional, Creasy, Caitlin, additional, Hurd, Mark, additional, Uraoka, Naohiro, additional, Canales, Jaime Rodriguez, additional, Koptez, Scott, additional, Hwu, Patrick, additional, Maitra, Anirban, additional, Bernatchez, Chantale, additional, Coyle, Scott M., additional, Roybel, Kole T., additional, Rupp, Levi J., additional, Santoro, Stephen P., additional, Secrest, Stephanie, additional, Spelman, Michael, additional, Ho, Hanson, additional, Gomes, Tina, additional, Tse, Tiffany, additional, Yung-Wu, Chia, additional, Taunton, Jack, additional, Lim, Wendell, additional, Emtage, Peter, additional, Moudgil, Tarsem, additional, Ballesteros-Merino, Carmen, additional, Hilton, Traci, additional, Paustian, Christopher, additional, Page, David, additional, Urba, Walter, additional, Fox, Bernard, additional, Bell, Bryan, additional, Patel, Ashish, additional, Olafsen, Tove, additional, Satpayev, Daulet, additional, Torgov, Michael, additional, Marchioni, Filippo, additional, Romero, Jason, additional, Jiang, Ziyue Karen, additional, Zamilpa, Charles, additional, Keppler, Jennifer S., additional, Mascioni, Alessandro, additional, Jia, Fang, additional, Lee, Chen-Yu, additional, Gudas, Jean, additional, Sullivan, Ryan J., additional, Hoshida, Yujin, additional, Logan, Theodore, additional, Khushalani, Nikhil, additional, Giobbie-Hurder, Anita, additional, Margolin, Kim, additional, Roder, Joanna, additional, Bhatt, Rupal, additional, Koon, Henry, additional, Olencki, Thomas, additional, Hutson, Thomas, additional, Curti, Brendan, additional, Blackmon, Shauna, additional, Mier, James W., additional, Puzanov, Igor, additional, Roder, Heinrich, additional, Stewart, John, additional, Amin, Asim, additional, Ernstoff, Marc S., additional, Clark, Joseph I., additional, Atkins, Michael B., additional, Kaufman, Howard L., additional, Sosman, Jeffrey, additional, Signoretti, Sabina, additional, McDermott, David F., additional, Anderson, Abraham A., additional, Milhem, Mohammed M., additional, Andtbacka, Robert H. I., additional, Minor, David, additional, Gorski, Kevin S., additional, Baker, Daniel M., additional, Hamid, Omid, additional, Akporiaye, Emmanuel, additional, Koguchi, Yoshinobu, additional, Sutcliffe, Kim, additional, Conder, Kristie, additional, Marron, Thomas, additional, Bhardwaj, Nina, additional, Hammerich, Linda, additional, George, Fiby, additional, Kim-Schulze, Seunghee, additional, Keler, Tibor, additional, Davis, Tom, additional, Crowley, Elizabeth, additional, Salazar, Andres, additional, Brody, Joshua, additional, Monjazeb, Arta, additional, Daly, Megan E., additional, Riess, Jonathan, additional, Li, Tianhong, additional, Murphy, William J., additional, Kelly, Karen, additional, Hu, Zhiwei, additional, Shen, Rulong, additional, Campbell, Amanda, additional, McMichael, Elizabeth, additional, Yu, Lianbo, additional, Ramaswam, Bhuvaneswari, additional, London, Cheryl A., additional, Xu, Tian, additional, Carson, William, additional, Kokolus, Kathleen M., additional, Repasky, Elizabeth A., additional, Schell, Todd D., additional, Drabick, Joseph D., additional, Messenheimer, David J., additional, Jensen, Shawn, additional, Rubinstein, Mark, additional, Andrijauskaite, Kristina, additional, Swiderska-syn, Marzena, additional, Lind, Kristin, additional, Choppin, Agnes, additional, Roell, Marina K., additional, Wrangle, John, additional, Rhode, Peter, additional, Wong, Hing, additional, Ahmad, Shamim, additional, Webb, Mason, additional, Abu-Eid, Rasha, additional, Shrimali, Rajeev, additional, Verma, Vivek, additional, Doroodchi, Atbin, additional, Berrong, Zuzana, additional, Yashar, David, additional, Samara, Raed, additional, Mkrtichyan, Mikayel, additional, Khleif, Samir, additional, Powell, Steven, additional, Gitau, Mark, additional, Sumey, Christopher, additional, Terrell, Andrew, additional, Lohr, Michele, additional, Nowak, Ryan K., additional, McGraw, Steven, additional, Jensen, Ash, additional, Blanchard, Miran, additional, Gold, Kathryn A., additional, Cohen, Ezra E. W., additional, Ellison, Christie, additional, Black, Lora, additional, Lee, John, additional, Spanos, William Chad, additional, Wennerberg, Erik, additional, Schwitzer, Emily, additional, Lhuillier, Claire, additional, Koelwyn, Graeme, additional, Hiner, Rebecca, additional, Jones, Lee, additional, Demaria, Sandra, additional, Amanda, Vandeveer, additional, Greiner, John W., additional, Schlom, Jeffrey, additional, Bookstaver, Michelle, additional, Jewell, Christopher M., additional, Gunderson, Andrew, additional, Boulmay, Brian, additional, Li, Rui, additional, Spieler, Bradley, additional, Happel, Kyle, additional, Feng, Zipei, additional, Dubay, Christopher, additional, Fisher, Brenda, additional, Aung, Sandra, additional, Mederos, Eileen, additional, Bifulco, Carlo B., additional, McNamara, Michael, additional, Bahjat, Keith, additional, Redmond, William, additional, Ochoa, Augusto, additional, Hu, Hong-Ming, additional, Mehta, Adi, additional, Lund-Johansen, Fridtjof, additional, Bedu-Addo, Frank, additional, Conn, Greg, additional, King, Michael, additional, Dutta, Panna, additional, Shepard, Robert, additional, Einstein, Mark, additional, Adams, Sylvia, additional, Wang, Ena, additional, Jin, Ping, additional, Novik, Yelena, additional, Morrison, Debra, additional, Oratz, Ruth, additional, Marincola, Franco M., additional, Stroncek, David, additional, Goldberg, Judith, additional, Formenti, Silvia C., additional, Galon, Jérôme, additional, Mlecnik, Bernhard, additional, Marliot, Florence, additional, Ou, Fang-Shu, additional, Lugli, Alessandro, additional, Zlobec, Inti, additional, Rau, Tilman T., additional, Nagtegaal, Iris D., additional, Vink-Borger, Elisa, additional, Hartmann, Arndt, additional, Geppert, Carol, additional, Roehrl, Michael H., additional, Bavi, Prashant, additional, Ohashi, Pamela S., additional, Wang, Julia Y., additional, Nguyen, Linh T., additional, Han, SeongJun, additional, MacGregor, Heather L., additional, Hafezi-Bakhtiari, Sara, additional, Wouters, Bradley G., additional, Kawakami, Yutaka, additional, Papivanova, Boryana, additional, Xu, Mingli, additional, Fujita, Tomonobu, additional, Hazama, Shoichi, additional, Suzuki, Nobuaki, additional, Nagano, Hiroaki, additional, Okuno, Kiyotaka, additional, Itoh, Kyogo, additional, Zavadova, Eva, additional, Vocka, Michal, additional, Spacek, Jan, additional, Petruzelka, Lubos, additional, Konopasek, Bohuslav, additional, Dundr, Pavel, additional, Skalova, Helena, additional, Torigoe, Toshihiko, additional, Sato, Noriyuki, additional, Furuhata, Tomohisa, additional, Takemasa, Ichiro, additional, Van den Eynde, Marc, additional, Jouret-Mourin, Anne, additional, Machiels, Jean-Pascal, additional, Fredriksen, Tessa, additional, Lafontaine, Lucie, additional, Buttard, Bénédicte, additional, Church, Sarah, additional, Maby, Pauline, additional, Angell, Helen, additional, Angelova, Mihaela, additional, Vasaturo, Angela, additional, Bindea, Gabriela, additional, Berger, Anne, additional, Lagorce, Christine, additional, Patel, Prabhu S., additional, Vora, Hemangini H., additional, Shah, Birva, additional, Patel, Jayendrakumar B., additional, Rajvik, Kruti N., additional, Pandya, Shashank J., additional, Shukla, Shilin N., additional, Wang, Yili, additional, Zhang, Guanjun, additional, Masucci, Giuseppe V., additional, Andersson, Emilia K., additional, Grizzi, Fabio, additional, Laghi, Luigi, additional, Botti, Gerardo, additional, Tatangelo, Fabiana, additional, Delrio, Paolo, additional, Cilberto, Gennaro, additional, Marincola, Franco, additional, Sargent, Daniel J., additional, Fox, Bernard A., additional, Algazi, Alain, additional, Tsai, Katy, additional, Rosenblum, Michael, additional, Nandoskar, Prachi, additional, Li, Amy, additional, Nonomura, John, additional, Takamura, Kathryn, additional, Dwyer, Mary, additional, Browning, Erica, additional, Talia, Reneta, additional, Twitty, Chris, additional, Gargosky, Sharron, additional, Campbell, Jean, additional, Le, Mai, additional, Pierce, Robert H., additional, Daud, Adil, additional, Gartrell, Robyn, additional, Marks, Douglas, additional, Stack, Edward, additional, Lu, Yan, additional, Izaki, Daisuke, additional, Beck, Kristen, additional, Jia, Dan Tong, additional, Armenta, Paul, additional, White-Stern, Ashley, additional, Fu, Yichun, additional, Blake, Zoe, additional, Taback, Bret, additional, Horst, Basil, additional, Saenger, Yvonne M., additional, Leonardo, Steven, additional, Gorden, Keith, additional, Fulton, Ross B., additional, Fraser, Kathryn, additional, Kangas, Takashi O., additional, Walsh, Richard, additional, Ertelt, Kathleen, additional, Graff, Jeremy, additional, Uhlik, Mark, additional, Sims, Jennifer S., additional, Lei, Liang, additional, Tsujiuchi, Takashi, additional, Bruce, Jeffrey N., additional, Canoll, Peter, additional, Tolcher, Anthony W, additional, Alley, Evan W, additional, Chichili, Gurunadh, additional, Canoll, Jan E, additional, Moore, Paul, additional, Bonvini, Ezio, additional, Johnson, Syd, additional, Shankar, Sadhna, additional, Vasselli, James, additional, Wigginton, Jon, additional, and Powderly, John, additional
Published: 2016
Full Text: View/download PDF

30. Responses of metastatic basal cell and cutaneous squamous cell carcinomas to anti-PD1 monoclonal antibody REGN2810

Author: Falchook, Gerald S., primary, Leidner, Rom, additional, Stankevich, Elizabeth, additional, Piening, Brian, additional, Bifulco, Carlo, additional, Lowy, Israel, additional, and Fury, Matthew G., additional
Published: 2016
Full Text: View/download PDF

31. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Author: Ager, Casey, primary, Reilley, Matthew, additional, Nicholas, Courtney, additional, Bartkowiak, Todd, additional, Jaiswal, Ashvin, additional, Curran, Michael, additional, Albershardt, Tina C., additional, Bajaj, Anshika, additional, Archer, Jacob F., additional, Reeves, Rebecca S., additional, Ngo, Lisa Y., additional, Berglund, Peter, additional, ter Meulen, Jan, additional, Denis, Caroline, additional, Ghadially, Hormas, additional, Arnoux, Thomas, additional, Chanuc, Fabien, additional, Fuseri, Nicolas, additional, Wilkinson, Robert W., additional, Wagtmann, Nicolai, additional, Morel, Yannis, additional, Andre, Pascale, additional, Atkins, Michael B., additional, Carlino, Matteo S., additional, Ribas, Antoni, additional, Thompson, John A., additional, Choueiri, Toni K., additional, Hodi, F. Stephen, additional, Hwu, Wen-Jen, additional, McDermott, David F., additional, Atkinson, Victoria, additional, Cebon, Jonathan S., additional, Fitzharris, Bernie, additional, Jameson, Michael B., additional, McNeil, Catriona, additional, Hill, Andrew G., additional, Mangin, Eric, additional, Ahamadi, Malidi, additional, van Vugt, Marianne, additional, van Zutphen, Mariëlle, additional, Ibrahim, Nageatte, additional, Long, Georgina V., additional, Gartrell, Robyn, additional, Blake, Zoe, additional, Simoes, Ines, additional, Fu, Yichun, additional, Saito, Takuro, additional, Qian, Yingzhi, additional, Lu, Yan, additional, Saenger, Yvonne M., additional, Budhu, Sadna, additional, De Henau, Olivier, additional, Zappasodi, Roberta, additional, Schlunegger, Kyle, additional, Freimark, Bruce, additional, Hutchins, Jeff, additional, Barker, Christopher A., additional, Wolchok, Jedd D., additional, Merghoub, Taha, additional, Burova, Elena, additional, Allbritton, Omaira, additional, Hong, Peter, additional, Dai, Jie, additional, Pei, Jerry, additional, Liu, Matt, additional, Kantrowitz, Joel, additional, Lai, Venus, additional, Poueymirou, William, additional, MacDonald, Douglas, additional, Ioffe, Ella, additional, Mohrs, Markus, additional, Olson, William, additional, Thurston, Gavin, additional, Capasso, Cristian, additional, Frascaro, Federica, additional, Carpi, Sara, additional, Tähtinen, Siri, additional, Feola, Sara, additional, Fusciello, Manlio, additional, Peltonen, Karita, additional, Martins, Beatriz, additional, Sjöberg, Madeleine, additional, Pesonen, Sari, additional, Ranki, Tuuli, additional, Kyruk, Lukasz, additional, Ylösmäki, Erkko, additional, Cerullo, Vincenzo, additional, Cerignoli, Fabio, additional, Xi, Biao, additional, Guenther, Garret, additional, Yu, Naichen, additional, Muir, Lincoln, additional, Zhao, Leyna, additional, Abassi, Yama, additional, Cervera-Carrascón, Víctor, additional, Siurala, Mikko, additional, Santos, João, additional, Havunen, Riikka, additional, Parviainen, Suvi, additional, Hemminki, Akseli, additional, Dalgleish, Angus, additional, Mudan, Satvinder, additional, DeBenedette, Mark, additional, Plachco, Ana, additional, Gamble, Alicia, additional, Grogan, Elizabeth W., additional, Krisko, John, additional, Tcherepanova, Irina, additional, Nicolette, Charles, additional, Dhupkar, Pooja, additional, Yu, Ling, additional, Kleinerman, Eugenie S., additional, Gordon, Nancy, additional, Grenga, Italia, additional, Lepone, Lauren, additional, Gameiro, Sofia, additional, Knudson, Karin M., additional, Fantini, Massimo, additional, Tsang, Kwong, additional, Hodge, James, additional, Donahue, Renee, additional, Schlom, Jeffrey, additional, Evans, Elizabeth, additional, Bussler, Holm, additional, Mallow, Crystal, additional, Reilly, Christine, additional, Torno, Sebold, additional, Scrivens, Maria, additional, Foster, Cathie, additional, Howell, Alan, additional, Balch, Leslie, additional, Knapp, Alyssa, additional, Leonard, John E., additional, Paris, Mark, additional, Fisher, Terry, additional, Hu-Lieskovan, Siwen, additional, Smith, Ernest, additional, Zauderer, Maurice, additional, Fogler, William, additional, Franklin, Marilyn, additional, Thayer, Matt, additional, Saims, Dan, additional, Magnani, John L., additional, Gong, Jian, additional, Gray, Michael, additional, Fromm, George, additional, de Silva, Suresh, additional, Giffin, Louise, additional, Xu, Xin, additional, Rose, Jason, additional, Schreiber, Taylor H., additional, Gameiro, Sofia R., additional, Clavijo, Paul E., additional, Allen, Clint T., additional, Hodge, James W., additional, Tsang, Kwong Y., additional, Grogan, Jane, additional, Manieri, Nicholas, additional, Chiang, Eugene, additional, Caplazi, Patrick, additional, Yadav, Mahesh, additional, Hagner, Patrick, additional, Chiu, Hsiling, additional, Waldman, Michelle, additional, Klippel, Anke, additional, Thakurta, Anjan, additional, Pourdehnad, Michael, additional, Gandhi, Anita, additional, Henrich, Ian, additional, Quick, Laura, additional, Young, Rob, additional, Chou, Margaret, additional, Hotson, Andrew, additional, Willingham, Stephen, additional, Ho, Po, additional, Choy, Carmen, additional, Laport, Ginna, additional, McCaffery, Ian, additional, Miller, Richard, additional, Tipton, Kimberly A., additional, Wong, Kenneth R., additional, Singson, Victoria, additional, Wong, Chihunt, additional, Chan, Chanty, additional, Huang, Yuanhiu, additional, Liu, Shouchun, additional, Richardson, Jennifer H., additional, Kavanaugh, W. Michael, additional, West, James, additional, Irving, Bryan A., additional, Jaini, Ritika, additional, Loya, Matthew, additional, Eng, Charis, additional, Johnson, Melissa L., additional, Adjei, Alex A., additional, Opyrchal, Mateusz, additional, Ramalingam, Suresh, additional, Janne, Pasi A., additional, Dominguez, George, additional, Gabrilovich, Dmitry, additional, de Leon, Laura, additional, Hasapidis, Jeannette, additional, Diede, Scott J., additional, Ordentlich, Peter, additional, Cruickshank, Scott, additional, Meyers, Michael L., additional, Hellmann, Matthew D., additional, Kalinski, Pawel, additional, Zureikat, Amer, additional, Edwards, Robert, additional, Muthuswamy, Ravi, additional, Obermajer, Nataša, additional, Urban, Julie, additional, Butterfield, Lisa H., additional, Gooding, William, additional, Zeh, Herbert, additional, Bartlett, David, additional, Zubkova, Olga, additional, Agapova, Larissa, additional, Kapralova, Marina, additional, Krasovskaia, Liudmila, additional, Ovsepyan, Armen, additional, Lykov, Maxim, additional, Eremeev, Artem, additional, Bokovanov, Vladimir, additional, Grigoryeva, Olga, additional, Karpov, Andrey, additional, Ruchko, Sergey, additional, Shuster, Alexandr, additional, Khalil, Danny N., additional, Campesato, Luis Felipe, additional, Li, Yanyun, additional, Lazorchak, Adam S., additional, Patterson, Troy D., additional, Ding, Yueyun, additional, Sasikumar, Pottayil, additional, Sudarshan, Naremaddepalli, additional, Gowda, Nagaraj, additional, Ramachandra, Raghuveer, additional, Samiulla, Dodheri, additional, Giri, Sanjeev, additional, Eswarappa, Rajesh, additional, Ramachandra, Murali, additional, Tuck, David, additional, Wyant, Timothy, additional, Leshem, Jasmin, additional, Liu, Xiu-fen, additional, Bera, Tapan, additional, Terabe, Masaki, additional, Bossenmaier, Birgit, additional, Niederfellner, Gerhard, additional, Reiter, Yoram, additional, Pastan, Ira, additional, Xia, Leiming, additional, Xia, Yang, additional, Hu, Yangyang, additional, Wang, Yi, additional, Bao, Yangyi, additional, Dai, Fu, additional, Huang, Shiang, additional, Hurt, Elaine, additional, Hollingsworth, Robert E., additional, Lum, Lawrence G., additional, Chang, Alfred E., additional, Wicha, Max S., additional, Li, Qiao, additional, Mace, Thomas, additional, Makhijani, Neil, additional, Talbert, Erin, additional, Young, Gregory, additional, Guttridge, Denis, additional, Conwell, Darwin, additional, Lesinski, Gregory B., additional, Gonzales, Rodney JM Macedo, additional, Huffman, Austin P., additional, Wang, Ximi K., additional, Reshef, Ran, additional, MacKinnon, Andy, additional, Chen, Jason, additional, Gross, Matt, additional, Marguier, Gisele, additional, Shwonek, Peter, additional, Sotirovska, Natalija, additional, Steggerda, Susanne, additional, Parlati, Francesco, additional, Makkouk, Amani, additional, Bennett, Mark K., additional, Emberley, Ethan, additional, Huang, Tony, additional, Li, Weiqun, additional, Neou, Silinda, additional, Pan, Alison, additional, Zhang, Jing, additional, Zhang, Winter, additional, Marshall, Netonia, additional, Marron, Thomas U., additional, Agudo, Judith, additional, Brown, Brian, additional, Brody, Joshua, additional, McQuinn, Christopher, additional, Farren, Matthew, additional, Komar, Hannah, additional, Shakya, Reena, additional, Ludwug, Thomas, additional, Morillon, Y. Maurice, additional, Hammond, Scott A., additional, Greiner, John W., additional, Nath, Pulak R., additional, Schwartz, Anthony L., additional, Maric, Dragan, additional, Roberts, David D., additional, Naing, Aung, additional, Papadopoulos, Kyriakos P., additional, Autio, Karen A., additional, Wong, Deborah J., additional, Patel, Manish, additional, Falchook, Gerald, additional, Pant, Shubham, additional, Ott, Patrick A., additional, Whiteside, Melinda, additional, Patnaik, Amita, additional, Mumm, John, additional, Janku, Filip, additional, Chan, Ivan, additional, Bauer, Todd, additional, Colen, Rivka, additional, VanVlasselaer, Peter, additional, Brown, Gail L., additional, Tannir, Nizar M., additional, Oft, Martin, additional, Infante, Jeffrey, additional, Lipson, Evan, additional, Gopal, Ajay, additional, Neelapu, Sattva S., additional, Armand, Philippe, additional, Spurgeon, Stephen, additional, Leonard, John P., additional, Sanborn, Rachel E., additional, Melero, Ignacio, additional, Gajewski, Thomas F., additional, Maurer, Matthew, additional, Perna, Serena, additional, Gutierrez, Andres A., additional, Clynes, Raphael, additional, Mitra, Priyam, additional, Suryawanshi, Satyendra, additional, Gladstone, Douglas, additional, Callahan, Margaret K., additional, Crooks, James, additional, Brown, Sheila, additional, Gauthier, Audrey, additional, de Boisferon, Marc Hillairet, additional, MacDonald, Andrew, additional, Brunet, Laura Rosa, additional, Rothwell, William T., additional, Bell, Peter, additional, Wilson, James M., additional, Sato-Kaneko, Fumi, additional, Yao, Shiyin, additional, Zhang, Shannon S., additional, Carson, Dennis A., additional, Guiducci, Cristina, additional, Coffman, Robert L., additional, Kitaura, Kazutaka, additional, Matsutani, Takaji, additional, Suzuki, Ryuji, additional, Hayashi, Tomoko, additional, Cohen, Ezra E. W., additional, Schaer, David, additional, Li, Yanxia, additional, Dobkin, Julie, additional, Amatulli, Michael, additional, Hall, Gerald, additional, Doman, Thompson, additional, Manro, Jason, additional, Dorsey, Frank Charles, additional, Sams, Lillian, additional, Holmgaard, Rikke, additional, Persaud, Krishnadatt, additional, Ludwig, Dale, additional, Surguladze, David, additional, Kauh, John S., additional, Novosiadly, Ruslan, additional, Kalos, Michael, additional, Driscoll, Kyla, additional, Pandha, Hardev, additional, Ralph, Christy, additional, Harrington, Kevin, additional, Curti, Brendan, additional, Akerley, Wallace, additional, Gupta, Sumati, additional, Melcher, Alan, additional, Mansfield, David, additional, Kaufman, David R., additional, Schmidt, Emmett, additional, Grose, Mark, additional, Davies, Bronwyn, additional, Karpathy, Roberta, additional, Shafren, Darren, additional, Shamalov, Katerina, additional, Cohen, Cyrille, additional, Sharma, Naveen, additional, Allison, James, additional, Shekarian, Tala, additional, Valsesia-Wittmann, Sandrine, additional, Caux, Christophe, additional, Marabelle, Aurelien, additional, Slomovitz, Brian M., additional, Moore, Kathleen M., additional, Youssoufian, Hagop, additional, Posner, Marshall, additional, Tewary, Poonam, additional, Brooks, Alan D., additional, Xu, Ya-Ming, additional, Wijeratne, Kithsiri, additional, Gunatilaka, Leslie A. A., additional, Sayers, Thomas J., additional, Vasilakos, John P., additional, Alston, Tesha, additional, Dovedi, Simon, additional, Elvecrog, James, additional, Grigsby, Iwen, additional, Herbst, Ronald, additional, Johnson, Karen, additional, Moeckly, Craig, additional, Mullins, Stefanie, additional, Siebenaler, Kristen, additional, SternJohn, Julius, additional, Tilahun, Ashenafi, additional, Tomai, Mark A., additional, Vogel, Katharina, additional, Vietsch, Eveline E., additional, Wellstein, Anton, additional, Wythes, Martin, additional, Crosignani, Stefano, additional, Tumang, Joseph, additional, Alekar, Shilpa, additional, Bingham, Patrick, additional, Cauwenberghs, Sandra, additional, Chaplin, Jenny, additional, Dalvie, Deepak, additional, Denies, Sofie, additional, De Maeseneire, Coraline, additional, Feng, JunLi, additional, Frederix, Kim, additional, Greasley, Samantha, additional, Guo, Jie, additional, Hardwick, James, additional, Kaiser, Stephen, additional, Jessen, Katti, additional, Kindt, Erick, additional, Letellier, Marie-Claire, additional, Li, Wenlin, additional, Maegley, Karen, additional, Marillier, Reece, additional, Miller, Nichol, additional, Murray, Brion, additional, Pirson, Romain, additional, Preillon, Julie, additional, Rabolli, Virginie, additional, Ray, Chad, additional, Ryan, Kevin, additional, Scales, Stephanie, additional, Srirangam, Jay, additional, Solowiej, Jim, additional, Stewart, Al, additional, Streiner, Nicole, additional, Torti, Vince, additional, Tsaparikos, Konstantinos, additional, Zheng, Xianxian, additional, Driessens, Gregory, additional, Gomes, Bruno, additional, Kraus, Manfred, additional, Xu, Chunxiao, additional, Zhang, Yanping, additional, Kradjian, Giorgio, additional, Qin, Guozhong, additional, Qi, Jin, additional, Xu, Xiaomei, additional, Marelli, Bo, additional, Yu, Huakui, additional, Guzman, Wilson, additional, Tighe, Rober, additional, Salazar, Rachel, additional, Lo, Kin-Ming, additional, English, Jessie, additional, Radvanyi, Laszlo, additional, Lan, Yan, additional, Postow, Michael, additional, Senbabaoglu, Yasin, additional, Gasmi, Billel, additional, Zhong, Hong, additional, Liu, Cailian, additional, Hirschhorhn-Cymerman, Daniel, additional, Zha, Yuanyuan, additional, Malnassy, Gregory, additional, Fulton, Noreen, additional, Park, Jae-Hyun, additional, Stock, Wendy, additional, Nakamura, Yusuke, additional, Liu, Hongtao, additional, Ju, Xiaoming, additional, Kosoff, Rachelle, additional, Ramos, Kimberly, additional, Coder, Brandon, additional, Petit, Robert, additional, Princiotta, Michael, additional, Perry, Kyle, additional, Zou, Jun, additional, Arina, Ainhoa, additional, Fernandez, Christian, additional, Zheng, Wenxin, additional, Beckett, Michael A., additional, Mauceri, Helena J., additional, Fu, Yang-Xin, additional, Weichselbaum, Ralph R., additional, Lewis, Whitney, additional, Han, Yanyan, additional, Wu, Yeting, additional, Yang, Chou, additional, Huang, Jing, additional, Wu, Dongyun, additional, Li, Jin, additional, Liang, Xiaoling, additional, Zhou, Xiangjun, additional, Hou, Jinlin, additional, Hassan, Raffit, additional, Jahan, Thierry, additional, Antonia, Scott J., additional, Kindler, Hedy L., additional, Alley, Evan W., additional, Honarmand, Somayeh, additional, Liu, Weiqun, additional, Leong, Meredith L., additional, Whiting, Chan C., additional, Nair, Nitya, additional, Enstrom, Amanda, additional, Lemmens, Edward E., additional, Tsujikawa, Takahiro, additional, Kumar, Sushil, additional, Coussens, Lisa M., additional, Murphy, Aimee L., additional, Brockstedt, Dirk G., additional, Koch, Sven D., additional, Sebastian, Martin, additional, Weiss, Christian, additional, Früh, Martin, additional, Pless, Miklos, additional, Cathomas, Richard, additional, Hilbe, Wolfgang, additional, Pall, Georg, additional, Wehler, Thomas, additional, Alt, Jürgen, additional, Bischoff, Helge, additional, Geissler, Michael, additional, Griesinger, Frank, additional, Kollmeier, Jens, additional, Papachristofilou, Alexandros, additional, Doener, Fatma, additional, Fotin-Mleczek, Mariola, additional, Hipp, Madeleine, additional, Hong, Henoch S., additional, Kallen, Karl-Josef, additional, Klinkhardt, Ute, additional, Stosnach, Claudia, additional, Scheel, Birgit, additional, Schroeder, Andreas, additional, Seibel, Tobias, additional, Gnad-Vogt, Ulrike, additional, Zippelius, Alfred, additional, Park, Ha-Ram, additional, Ahn, Yong-Oon, additional, Kim, Tae Min, additional, Kim, Soyeon, additional, Kim, Seulki, additional, Lee, Yu Soo, additional, Keam, Bhumsuk, additional, Kim, Dong-Wan, additional, Heo, Dae Seog, additional, Pilon-Thomas, Shari, additional, Weber, Amy, additional, Morse, Jennifer, additional, Kodumudi, Krithika, additional, Liu, Hao, additional, Mullinax, John, additional, Sarnaik, Amod A., additional, Pike, Luke, additional, Bang, Andrew, additional, Balboni, Tracy, additional, Taylor, Allison, additional, Spektor, Alexander, additional, Wilhite, Tyler, additional, Krishnan, Monica, additional, Cagney, Daniel, additional, Alexander, Brian, additional, Aizer, Ayal, additional, Buchbinder, Elizabeth, additional, Awad, Mark, additional, Ghandi, Leena, additional, Schoenfeld, Jonathan, additional, Lessey-Morillon, Elizabeth, additional, Ridnour, Lisa, additional, Segal, Neil H., additional, Sharma, Manish, additional, Le, Dung T., additional, Ferris, Robert L., additional, Zelenetz, Andrew D., additional, Levy, Ronald, additional, Lossos, Izidore S., additional, Jacobson, Caron, additional, Ramchandren, Radhakrishnan, additional, Godwin, John, additional, Colevas, A. Dimitrios, additional, Meier, Roland, additional, Krishnan, Suba, additional, Gu, Xuemin, additional, Neely, Jaclyn, additional, Timmerman, John, additional, Vanpouille-Box, Claire I., additional, Formenti, Silvia C., additional, Demaria, Sandra, additional, Wennerberg, Erik, additional, Mediero, Aranzazu, additional, Cronstein, Bruce N., additional, Gustafson, Michael P., additional, DiCostanzo, AriCeli, additional, Wheatley, Courtney, additional, Kim, Chul-Ho, additional, Bornschlegl, Svetlana, additional, Gastineau, Dennis A., additional, Johnson, Bruce D., additional, Dietz, Allan B., additional, MacDonald, Cameron, additional, Bucsek, Mark, additional, Qiao, Guanxi, additional, Hylander, Bonnie, additional, Repasky, Elizabeth, additional, Turbitt, William J., additional, Xu, Yitong, additional, Mastro, Andrea, additional, Rogers, Connie J., additional, Withers, Sita, additional, Wang, Ziming, additional, Khuat, Lam T., additional, Dunai, Cordelia, additional, Blazar, Bruce R., additional, Longo, Dan, additional, Rebhun, Robert, additional, Grossenbacher, Steven K., additional, Monjazeb, Arta, additional, Murphy, William J., additional, Rowlinson, Scott, additional, Agnello, Giulia, additional, Alters, Susan, additional, Lowe, David, additional, Scharping, Nicole, additional, Menk, Ashley V., additional, Whetstone, Ryan, additional, Zeng, Xue, additional, Delgoffe, Greg M., additional, Santos, Patricia M., additional, Shi, Jian, additional, Delgoffe, Greg, additional, Nagasaka, Misako, additional, Sukari, Ammar, additional, Byrne-Steele, Miranda, additional, Pan, Wenjing, additional, Hou, Xiaohong, additional, Brown, Brittany, additional, Eisenhower, Mary, additional, Han, Jian, additional, Collins, Natalie, additional, Manguso, Robert, additional, Pope, Hans, additional, Shrestha, Yashaswi, additional, Boehm, Jesse, additional, Haining, W. Nicholas, additional, Cron, Kyle R., additional, Sivan, Ayelet, additional, Aquino-Michaels, Keston, additional, Orecchioni, Marco, additional, Bedognetti, Davide, additional, Hendrickx, Wouter, additional, Fuoco, Claudia, additional, Spada, Filomena, additional, Sgarrella, Francesco, additional, Cesareni, Gianni, additional, Marincola, Francesco, additional, Kostarelos, Kostas, additional, Bianco, Alberto, additional, Delogu, Lucia, additional, Roelands, Jessica, additional, Boughorbel, Sabri, additional, Decock, Julie, additional, Presnell, Scott, additional, Wang, Ena, additional, Marincola, Franco M., additional, Kuppen, Peter, additional, Ceccarelli, Michele, additional, Rinchai, Darawan, additional, Chaussabel, Damien, additional, Miller, Lance, additional, Nguyen, Andrew, additional, Sanborn, J. Zachary, additional, Vaske, Charles, additional, Rabizadeh, Shahrooz, additional, Niazi, Kayvan, additional, Benz, Steven, additional, Patel, Shashank, additional, Restifo, Nicholas, additional, White, James, additional, Angiuoli, Sam, additional, Sausen, Mark, additional, Jones, Sian, additional, Sevdali, Maria, additional, Simmons, John, additional, Velculescu, Victor, additional, Diaz, Luis, additional, Zhang, Theresa, additional, Sims, Jennifer S., additional, Barton, Sunjay M., additional, Kadenhe-Chiweshe, Angela, additional, Dela Cruz, Filemon, additional, Turk, Andrew T., additional, Mazzeo, Christopher F., additional, Kung, Andrew L., additional, Bruce, Jeffrey N., additional, Yamashiro, Darrell J., additional, Connolly, Eileen P., additional, Baird, Jason, additional, Crittenden, Marka, additional, Friedman, David, additional, Xiao, Hong, additional, Leidner, Rom, additional, Bell, Bryan, additional, Young, Kristina, additional, Gough, Michael, additional, Bian, Zhen, additional, Kidder, Koby, additional, Liu, Yuan, additional, Curran, Emily, additional, Chen, Xiufen, additional, Corrales, Leticia P., additional, Kline, Justin, additional, Aguilar, Ethan G., additional, Guerriero, Jennifer, additional, Sotayo, Alaba, additional, Ponichtera, Holly, additional, Pourzia, Alexandra, additional, Schad, Sara, additional, Carrasco, Ruben, additional, Lazo, Suzan, additional, Bronson, Roderick, additional, Letai, Anthony, additional, Kornbluth, Richard S., additional, Gupta, Sachin, additional, Termini, James, additional, Guirado, Elizabeth, additional, Stone, Geoffrey W., additional, Meyer, Christina, additional, Helming, Laura, additional, Wilson, Nicholas, additional, Hofmeister, Robert, additional, Neubert, Natalie J., additional, Tillé, Laure, additional, Barras, David, additional, Soneson, Charlotte, additional, Baumgaertner, Petra, additional, Rimoldi, Donata, additional, Gfeller, David, additional, Delorenzi, Mauro, additional, Fuertes Marraco, Silvia A., additional, Speiser, Daniel E., additional, Abraham, Tara S., additional, Xiang, Bo, additional, Magee, Michael S., additional, Waldman, Scott A., additional, Snook, Adam E., additional, Blogowski, Wojciech, additional, Zuba-Surma, Ewa, additional, Budkowska, Marta, additional, Salata, Daria, additional, Dolegowska, Barbara, additional, Starzynska, Teresa, additional, Chan, Leo, additional, Somanchi, Srinivas, additional, McCulley, Kelsey, additional, Lee, Dean, additional, Buettner, Nico, additional, Shi, Feng, additional, Myers, Paisley T., additional, Curbishley, Stuart, additional, Penny, Sarah A., additional, Steadman, Lora, additional, Millar, David, additional, Speers, Ellen, additional, Ruth, Nicola, additional, Wong, Gabriel, additional, Thimme, Robert, additional, Adams, David, additional, Cobbold, Mark, additional, Thomas, Remy, additional, Al-Muftah, Mariam, additional, Wong, Michael KK, additional, Morse, Michael, additional, Clark, Joseph I., additional, Kaufman, Howard L., additional, Daniels, Gregory A., additional, Hua, Hong, additional, Rao, Tharak, additional, Dutcher, Janice P., additional, Kang, Kai, additional, Saunthararajah, Yogen, additional, Velcheti, Vamsidhar, additional, Kumar, Vikas, additional, Anwar, Firoz, additional, Verma, Amita, additional, Chheda, Zinal, additional, Kohanbash, Gary, additional, Sidney, John, additional, Okada, Kaori, additional, Shrivastav, Shruti, additional, Carrera, Diego A., additional, Liu, Shuming, additional, Jahan, Naznin, additional, Mueller, Sabine, additional, Pollack, Ian F., additional, Carcaboso, Angel M., additional, Sette, Alessandro, additional, Hou, Yafei, additional, Okada, Hideho, additional, Field, Jessica J., additional, Zeng, Weiping, additional, Shih, Vincent FS, additional, Law, Che-Leung, additional, Senter, Peter D., additional, Gardai, Shyra J., additional, Okeley, Nicole M., additional, Abelin, Jennifer G., additional, Saeed, Abu Z., additional, Malaker, Stacy A., additional, Shabanowitz, Jeffrey, additional, Ward, Stephen T., additional, Hunt, Donald F., additional, Profusek, Pam, additional, Wood, Laura, additional, Shepard, Dale, additional, Grivas, Petros, additional, Kapp, Kerstin, additional, Volz, Barbara, additional, Oswald, Detlef, additional, Wittig, Burghardt, additional, Schmidt, Manuel, additional, Sefrin, Julian P., additional, Hillringhaus, Lars, additional, Lifke, Valeria, additional, Lifke, Alexander, additional, Skaletskaya, Anna, additional, Ponte, Jose, additional, Chittenden, Thomas, additional, Setiady, Yulius, additional, Sivado, Eva, additional, Thomas, Vincent, additional, El Alaoui, Meddy, additional, Papot, Sébastien, additional, Dumontet, Charles, additional, Dyson, Mike, additional, McCafferty, John, additional, El Alaoui, Said, additional, Bommareddy, Praveen K., additional, Zloza, Andrew, additional, Kohlhapp, Frederick, additional, Silk, Ann W., additional, Jhawar, Sachin, additional, Paneque, Tomas, additional, Newman, Jenna, additional, Beltran, Pedro, additional, Cao, Felicia, additional, Hong, Bang-Xing, additional, Rodriguez-Cruz, Tania, additional, Song, Xiao-Tong, additional, Gottschalk, Stephen, additional, Calderon, Hugo, additional, Illingworth, Sam, additional, Brown, Alice, additional, Fisher, Kerry, additional, Seymour, Len, additional, Champion, Brian, additional, Eriksson, Emma, additional, Wenthe, Jessica, additional, Hellström, Ann-Charlotte, additional, Paul-Wetterberg, Gabriella, additional, Loskog, Angelica, additional, Milenova, Ioanna, additional, Ståhle, Magnus, additional, Jarblad-Leja, Justyna, additional, Ullenhag, Gustav, additional, Dimberg, Anna, additional, Moreno, Rafael, additional, Alemany, Ramon, additional, Goyal, Sharad, additional, Silk, Ann, additional, Mehnert, Janice, additional, Gabrail, Nashat, additional, Bryan, Jennifer, additional, Medina, Daniel, additional, Mitchell, Leah, additional, Yagiz, Kader, additional, Lopez, Fernando, additional, Mendoza, Daniel, additional, Munday, Anthony, additional, Gruber, Harry, additional, Jolly, Douglas, additional, Fuhrmann, Steven, additional, Radoja, Sasa, additional, Tan, Wei, additional, Pourchet, Aldo, additional, Frey, Alan, additional, Mohr, Ian, additional, Mulvey, Matthew, additional, Andtbacka, Robert H. I., additional, Ross, Merrick, additional, Agarwala, Sanjiv, additional, Grossmann, Kenneth, additional, Taylor, Matthew, additional, Vetto, John, additional, Neves, Rogerio, additional, Daud, Adil, additional, Khong, Hung, additional, Meek, Stephanie M., additional, Ungerleider, Richard, additional, Welden, Scott, additional, Tanaka, Maki, additional, Williams, Matthew, additional, Hallmeyer, Sigrun, additional, Fox, Bernard, additional, Feng, Zipei, additional, Paustian, Christopher, additional, Bifulco, Carlo, additional, Zafar, Sadia, additional, Hemminki, Otto, additional, Bramante, Simona, additional, Vassilev, Lotta, additional, Wang, Hongjie, additional, Lieber, Andre, additional, Hemmi, Silvio, additional, de Gruijl, Tanja, additional, Kanerva, Anna, additional, Ansari, Tameem, additional, Sundararaman, Srividya, additional, Roen, Diana, additional, Lehmann, Paul, additional, Bloom, Anja C., additional, Bender, Lewis H., additional, Walters, Ian B., additional, Berzofsky, Jay A., additional, Chapelin, Fanny, additional, Ahrens, Eric T., additional, DeFalco, Jeff, additional, Harbell, Michael, additional, Manning-Bog, Amy, additional, Scholz, Alexander, additional, Zhang, Danhui, additional, Baia, Gilson, additional, Tan, Yann Chong, additional, Sokolove, Jeremy, additional, Kim, Dongkyoon, additional, Williamson, Kevin, additional, Chen, Xiaomu, additional, Colrain, Jillian, additional, Santo, Gregg Espiritu, additional, Nguyen, Ngan, additional, Volkmuth, Wayne, additional, Greenberg, Norman, additional, Robinson, William, additional, Emerling, Daniel, additional, Drake, Charles G., additional, Petrylak, Daniel P., additional, Antonarakis, Emmanuel S., additional, Kibel, Adam S., additional, Chang, Nancy N., additional, Vu, Tuyen, additional, Campogan, Dwayne, additional, Haynes, Heather, additional, Trager, James B., additional, Sheikh, Nadeem A., additional, Quinn, David I., additional, Kirk, Peter, additional, Addepalli, Murali, additional, Chang, Thomas, additional, Zhang, Ping, additional, Konakova, Marina, additional, Hagihara, Katsunobu, additional, Pai, Steven, additional, VanderVeen, Laurie, additional, Obalapur, Palakshi, additional, Kuo, Peiwen, additional, Quach, Phi, additional, Fong, Lawrence, additional, Charych, Deborah H., additional, Zalevsky, Jonathan, additional, Langowski, John L., additional, Kirksey, Yolanda, additional, Nutakki, Ravi, additional, Kolarkar, Shalini, additional, Pena, Rhoneil, additional, Hoch, Ute, additional, Doberstein, Stephen K., additional, Cha, John, additional, Mallon, Zach, additional, Perez, Myra, additional, McDaniel, Amanda, additional, Anand, Snjezana, additional, Uecker, Darrin, additional, Nuccitelli, Richard, additional, Wieckowski, Eva, additional, Muthuswamy, Ravikumar, additional, Ravindranathan, Roshni, additional, Renrick, Ariana N., additional, Thounaojam, Menaka, additional, Thomas, Portia, additional, Pellom, Samuel, additional, Shanker, Anil, additional, Dudimah, Duafalia, additional, Brooks, Alan, additional, Su, Yu-Lin, additional, Adamus, Tomasz, additional, Zhang, Qifang, additional, Nechaev, Sergey, additional, Kortylewski, Marcin, additional, Wei, Spencer, additional, Anderson, Clark, additional, Tang, Chad, additional, Schoenhals, Jonathan, additional, Tsouko, Efrosini, additional, Heymach, John, additional, de Groot, Patricia, additional, Chang, Joe, additional, Hess, Kenneth R., additional, Diab, Adi, additional, Sharma, Padmanee, additional, Hong, David, additional, Welsh, James, additional, Parsons, Andrea J., additional, Leleux, Jardin, additional, Ascarateil, Stephane, additional, Koziol, Marie Eve, additional, Bai, Dina, additional, Dai, Peihong, additional, Wang, Weiyi, additional, Yang, Ning, additional, Shuman, Stewart, additional, Deng, Liang, additional, Dillon, Patrick, additional, Petroni, Gina, additional, Brenin, David, additional, Bullock, Kim, additional, Olson, Walter, additional, Smolkin, Mark E., additional, Smith, Kelly, additional, Nail, Carmel, additional, Slingluff, Craig L., additional, Sharma, Meenu, additional, Fa’ak, Faisal, additional, Janssen, Louise, additional, Khong, Hiep, additional, Xiao, Zhilan, additional, Hailemichael, Yared, additional, Singh, Manisha, additional, Vianden, Christina, additional, Overwijk, Willem W., additional, Facciabene, Andrea, additional, Stefano, Pierini, additional, Chongyung, Fang, additional, Rafail, Stavros, additional, Nielsen, Michael, additional, Vanderslice, Peter, additional, Woodside, Darren G., additional, Market, Robert V., additional, Biediger, Ronald J., additional, Marathi, Upendra K., additional, Hollevoet, Kevin, additional, Geukens, Nick, additional, Declerck, Paul, additional, Joly, Nathalie, additional, McIntosh, Laura, additional, Paramithiotis, Eustache, additional, Rizell, Magnus, additional, Sternby, Malin, additional, Andersson, Bengt, additional, Karlsson-Parra, Alex, additional, Kuai, Rui, additional, Ochyl, Lukasz, additional, Schwendeman, Anna, additional, Moon, James, additional, Deng, Weiwen, additional, Hudson, Thomas E., additional, Hanson, Bill, additional, Rae, Chris S., additional, Burrill, Joel, additional, Skoble, Justin, additional, Katibah, George, additional, deVries, Michele, additional, Lauer, Peter, additional, Dubensky, Thomas W., additional, Chen, Xin, additional, Zhou, Li, additional, Ren, Xiubao, additional, Aggarwal, Charu, additional, Mangrolia, Drishty, additional, Cohen, Roger, additional, Weinstein, Gregory, additional, Morrow, Matthew, additional, Bauml, Joshua, additional, Kraynyak, Kim, additional, Boyer, Jean, additional, Yan, Jian, additional, Lee, Jessica, additional, Humeau, Laurent, additional, Oyola, Sandra, additional, Duff, Susan, additional, Weiner, David, additional, Yang, Zane, additional, Bagarazzi, Mark, additional, McNeel, Douglas G., additional, Eickhoff, Jens, additional, Jeraj, Robert, additional, Staab, Mary Jane, additional, Straus, Jane, additional, Rekoske, Brian, additional, Liu, Glenn, additional, Melssen, Marit, additional, Grosh, William, additional, Varhegyi, Nikole, additional, Galeassi, Nadejda, additional, Deacon, Donna H., additional, Gaughan, Elizabeth, additional, Ghisoli, Maurizio, additional, Barve, Minal, additional, Mennel, Robert, additional, Wallraven, Gladice, additional, Manning, Luisa, additional, Senzer, Neil, additional, Nemunaitis, John, additional, Ogasawara, Masahiro, additional, Ota, Shuichi, additional, Peace, Kaitlin M., additional, Hale, Diane F., additional, Vreeland, Timothy J., additional, Jackson, Doreen O., additional, Berry, John S., additional, Trappey, Alfred F., additional, Herbert, Garth S., additional, Clifton, Guy T., additional, Hardin, Mark O., additional, Toms, Anne, additional, Qiao, Na, additional, Litton, Jennifer, additional, Peoples, George E., additional, Mittendorf, Elizabeth A., additional, Ghamsari, Lila, additional, Flano, Emilio, additional, Jacques, Judy, additional, Liu, Biao, additional, Havel, Jonathan, additional, Makarov, Vladimir, additional, Chan, Timothy A., additional, Flechtner, Jessica B., additional, Facciponte, John, additional, Ugel, Stefano, additional, De Sanctis, Francesco, additional, Coukos, George, additional, Paris, Sébastien, additional, Pottier, Agnes, additional, Levy, Laurent, additional, Lu, Bo, additional, Cappuccini, Federica, additional, Pollock, Emily, additional, Bryant, Richard, additional, Hamdy, Freddie, additional, Hill, Adrian, additional, Redchenko, Irina, additional, Sultan, Hussein, additional, Kumai, Takumi, additional, Fesenkova, Valentyna, additional, Celis, Esteban, additional, Fernando, Ingrid, additional, Palena, Claudia, additional, David, Justin M., additional, Gabitzsch, Elizabeth, additional, Jones, Frank, additional, Gulley, James L., additional, Herranz, Mireia Uribe, additional, Wada, Hiroshi, additional, Shimizu, Atsushi, additional, Osada, Toshihiro, additional, Fukaya, Satoshi, additional, Sasaki, Eiji, additional, Abolhalaj, Milad, additional, Askmyr, David, additional, Lundberg, Kristina, additional, Albrekt, Ann-Sofie, additional, Greiff, Lennart, additional, Lindstedt, Malin, additional, Flies, Dallas B., additional, Higuchi, Tomoe, additional, Ornatowski, Wojciech, additional, Harris, Jaryse, additional, Adams, Sarah F., additional, Aguilera, Todd, additional, Rafat, Marjan, additional, Castellini, Laura, additional, Shehade, Hussein, additional, Kariolis, Mihalis, additional, Jang, Dadi, additional, vonEbyen, Rie, additional, Graves, Edward, additional, Ellies, Lesley, additional, Rankin, Erinn, additional, Koong, Albert, additional, Giaccia, Amato, additional, Ajina, Reham, additional, Wang, Shangzi, additional, Smith, Jill, additional, Pierobon, Mariaelena, additional, Jablonski, Sandra, additional, Petricoin, Emanuel, additional, Weiner, Louis M., additional, Sherry, Lorcan, additional, Waller, John, additional, Anderson, Mark, additional, Bigley, Alison, additional, Bernatchez, Chantale, additional, Haymaker, Cara, additional, Kluger, Harriet, additional, Tetzlaff, Michael, additional, Jackson, Natalie, additional, Gergel, Ivan, additional, Tagliaferri, Mary, additional, Hwu, Patrick, additional, Snzol, Mario, additional, Hurwitz, Michael, additional, Barberi, Theresa, additional, Martin, Allison, additional, Suresh, Rahul, additional, Barakat, David, additional, Harris-Bookman, Sarah, additional, Drake, Charles, additional, Friedman, Alan, additional, Berkey, Sara, additional, Downs-Canner, Stephanie, additional, Edwards, Robert P., additional, Curiel, Tyler, additional, Odunsi, Kunle, additional, Bruno, Tullia C., additional, Moore, Brandon, additional, Squalls, Olivia, additional, Ebner, Peggy, additional, Waugh, Katherine, additional, Mitchell, John, additional, Franklin, Wilbur, additional, Merrick, Daniel, additional, McCarter, Martin, additional, Palmer, Brent, additional, Kern, Jeffrey, additional, Vignali, Dario, additional, Slansky, Jill, additional, Chan, Anissa S. H., additional, Qiu, Xiaohong, additional, Fraser, Kathryn, additional, Jonas, Adria, additional, Ottoson, Nadine, additional, Gordon, Keith, additional, Kangas, Takashi O., additional, Leonardo, Steven, additional, Ertelt, Kathleen, additional, Walsh, Richard, additional, Uhlik, Mark, additional, Graff, Jeremy, additional, Bose, Nandita, additional, Gupta, Ravi, additional, Mandloi, Nitin, additional, Paul, Kiran, additional, Patil, Ashwini, additional, Sathian, Rekha, additional, Mohan, Aparna, additional, Manoharan, Malini, additional, Chaudhuri, Amitabha, additional, Chen, Yu, additional, Lin, Jing, additional, Ye, Yun-bin, additional, Xu, Chun-wei, additional, Chen, Gang, additional, Guo, Zeng-qing, additional, Komarov, Andrey, additional, Chenchik, Alex, additional, Makhanov, Michael, additional, Frangou, Costa, additional, Zheng, Yi, additional, Coltharp, Carla, additional, Unfricht, Darryn, additional, Dilworth, Ryan, additional, Fridman, Leticia, additional, Liu, Linying, additional, Rajopadhye, Milind, additional, Miller, Peter, additional, Concha-Benavente, Fernando, additional, Bauman, Julie, additional, Trivedi, Sumita, additional, Srivastava, Raghvendra, additional, Ohr, James, additional, Heron, Dwight, additional, Duvvuri, Uma, additional, Kim, Seungwon, additional, Torrey, Heather, additional, Mera, Toshi, additional, Okubo, Yoshiaki, additional, Vanamee, Eva, additional, Foster, Rosemary, additional, Faustman, Denise, additional, Stack, Edward, additional, Izaki, Daisuke, additional, Beck, Kristen, additional, Jia, Dan Tong, additional, Armenta, Paul, additional, White-Stern, Ashley, additional, Marks, Douglas, additional, Taback, Bret, additional, Horst, Basil, additional, Glickman, Laura Hix, additional, Kanne, David B., additional, Gauthier, Kelsey S., additional, Desbien, Anthony L., additional, Francica, Brian, additional, Leong, Justin L., additional, Sung, Leonard, additional, Metchette, Ken, additional, Kasibhatla, Shailaja, additional, Pferdekamper, Anne Marie, additional, Zheng, Lianxing, additional, Cho, Charles, additional, Feng, Yan, additional, McKenna, Jeffery M., additional, Tallarico, John, additional, Bender, Steven, additional, Ndubaku, Chudi, additional, McWhirter, Sarah M., additional, Gugel, Elena Gonzalez, additional, Bell, Charles J. M., additional, Munk, Adiel, additional, Muniz, Luciana, additional, Bhardwaj, Nina, additional, Zhao, Fei, additional, Evans, Kathy, additional, Xiao, Christine, additional, Holtzhausen, Alisha, additional, Hanks, Brent A., additional, Scholler, Nathalie, additional, Yin, Catherine, additional, Van der Meijs, Pien, additional, Prantner, Andrew M., additional, Krejsa, Cecile M., additional, Smith, Leia, additional, Johnson, Brian, additional, Branstetter, Daniel, additional, Stein, Paul L., additional, Jaen, Juan C., additional, Tan, Joanne BL, additional, Chen, Ada, additional, Park, Timothy, additional, Powers, Jay P., additional, Sexton, Holly, additional, Xu, Guifen, additional, Young, Steve W., additional, Schindler, Ulrike, additional, Deng, Wentao, additional, Klinke, David John, additional, Komar, Hannah M., additional, Serpa, Gregory, additional, Elnaggar, Omar, additional, Hart, Philip, additional, Schmidt, Carl, additional, Dillhoff, Mary, additional, Jin, Ming, additional, Ostrowski, Michael C., additional, Koti, Madhuri, additional, Au, Katrina, additional, Peterson, Nichole, additional, Truesdell, Peter, additional, Reid-Schachter, Gillian, additional, Graham, Charles, additional, Craig, Andrew, additional, Francis, Julie-Ann, additional, Kotlan, Beatrix, additional, Balatoni, Timea, additional, Farkas, Emil, additional, Toth, Laszlo, additional, Ujhelyi, Mihaly, additional, Savolt, Akos, additional, Doleschall, Zoltan, additional, Horvath, Szabolcs, additional, Eles, Klara, additional, Olasz, Judit, additional, Csuka, Orsolya, additional, Kasler, Miklos, additional, Liszkay, Gabriella, additional, Barnea, Eytan, additional, Blakely, Collin, additional, Flynn, Patrick, additional, Goodman, Reid, additional, Bueno, Raphael, additional, Sugarbaker, David, additional, Jablons, David, additional, Broaddus, V. Courtney, additional, West, Brian, additional, Kunk, Paul R., additional, Obeid, Joseph M., additional, Winters, Kevin, additional, Pramoonjago, Patcharin, additional, Stelow, Edward B., additional, Bauer, Todd W., additional, Rahma, Osama E., additional, Lamble, Adam, additional, Kosaka, Yoko, additional, Huang, Fei, additional, Saser, Kate A., additional, Adams, Homer, additional, Tognon, Christina E., additional, Laderas, Ted, additional, McWeeney, Shannon, additional, Loriaux, Marc, additional, Tyner, Jeffery W., additional, Druker, Brian J., additional, Lind, Evan F., additional, Liu, Zhuqing, additional, Lu, Shanhong, additional, Kane, Lawrence P., additional, Shayan, Gulidanna, additional, Femel, Julia, additional, Lane, Ryan, additional, Booth, Jamie, additional, Lund, Amanda W., additional, Rodriguez, Anthony, additional, Engelhard, Victor H., additional, Metelli, Alessandra, additional, Wu, Bill X., additional, Fugle, Caroline W., additional, Saleh, Rachidi, additional, Sun, Shaoli, additional, Wu, Jennifer, additional, Liu, Bei, additional, Li, Zihai, additional, Morris, Zachary S., additional, Guy, Emily I., additional, Heinze, Clinton, additional, Kler, Jasdeep, additional, Gressett, Monica M., additional, Werner, Lauryn R., additional, Gillies, Stephen D., additional, Korman, Alan J., additional, Loibner, Hans, additional, Hank, Jacquelyn A., additional, Rakhmilevich, Alexander L., additional, Harari, Paul M., additional, Sondel, Paul M., additional, Huelsmann, Erica, additional, Broucek, Joseph, additional, Brech, Dorothee, additional, Straub, Tobias, additional, Irmler, Martin, additional, Beckers, Johannes, additional, Buettner, Florian, additional, Schaeffeler, Elke, additional, Schwab, Matthias, additional, Noessner, Elfriede, additional, Wolfreys, Alison, additional, Da Costa, Andre, additional, Silva, John, additional, Crosby, Andrea, additional, Staelens, Ludovicus, additional, Craggs, Graham, additional, Cauvin, Annick, additional, Mason, Sean, additional, Paterson, Alison M., additional, Lake, Andrew C., additional, Armet, Caroline M., additional, O’Connor, Rachel W., additional, Hill, Jonathan A., additional, Normant, Emmanuel, additional, Adam, Ammar, additional, Biniszkiewicz, Detlev M., additional, Chappel, Scott C., additional, Palombella, Vito J., additional, Holland, Pamela M., additional, Becker, Annette, additional, Leleti, Manmohan R., additional, Newcomb, Eric, additional, Tan, Joanne B. L., additional, Rapisuwon, Suthee, additional, Radfar, Arash, additional, Gardner, Kellie, additional, Gibney, Geoffrey, additional, Atkins, Michael, additional, Rennier, Keith R., additional, Crowder, Robert, additional, Wang, Ping, additional, Pachynski, Russell K., additional, Carrero, Rosa M. Santana, additional, Rivas, Sarai, additional, Beceren-Braun, Figen, additional, Anthony, Scott, additional, Schluns, Kimberly S., additional, Sawant, Deepali, additional, Chikina, Maria, additional, Yano, Hiroshi, additional, Workman, Creg, additional, Salerno, Elise, additional, Mauldin, Ileana, additional, Deacon, Donna, additional, Shea, Sofia, additional, Pinczewski, Joel, additional, Gajewski, Thomas, additional, Spranger, Stefani, additional, Horton, Brendan, additional, Suzuki, Akiko, additional, Leland, Pamela, additional, Joshi, Bharat H., additional, Puri, Raj K., additional, Sweis, Randy F., additional, Bao, Riyue, additional, Luke, Jason, additional, Theodoraki, Marie-Nicole, additional, Mogundo, Frances-Mary, additional, Won, Haejung, additional, Moreira, Dayson, additional, Gao, Chan, additional, Zhao, Xingli, additional, Duttagupta, Priyanka, additional, Jones, Jeremy, additional, D’Apuzzo, Massimo, additional, and Pal, Sumanta, additional
Published: 2016
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32. Adoptive TIL in HPV-negative oral scca

Author: Leidner, Rom, primary, Curti, Brendan D, additional, Payne, Roxanne M, additional, Urba, Walter, additional, Bahjat, Keith S, additional, Koguchi, Yoshinobu, additional, Nelson, Krista, additional, Moore, Jennifer A, additional, Crittenden, Marka, additional, Ying, Yedeh, additional, Patel, Ashish, additional, Cheng, Allen, additional, Bui, Tuan G, additional, Hilton, Traci, additional, Paustian, Christopher, additional, Puri, Sachin, additional, Hu, Hong Ming, additional, Bifulco, Carlo, additional, Feng, Zipei, additional, Bell, R Bryan, additional, and Fox, Bernard, additional
Published: 2015
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33. An evaluation of autologous tumor-reactive TIL generation from head and neck squamous cell cancers

Author: Mougdil, Tarsem, primary, Paustian, Christopher, additional, Feng, Zipei, additional, Leidner, Rom, additional, Dubay, Christopher, additional, Curti, Brendan D, additional, Hu, Hong-Ming, additional, Urba, Walter, additional, Bifulco, Carlo, additional, Fox, Bernard, additional, and Bell, Brian, additional
Published: 2015
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34. Assessment of the tumor immune-environment in patients with head and neck cancer

Author: Feng, Zipei, primary, Bethmann, Daniel, additional, Kappler, Matthias, additional, Ballesteros-Merino, Carmen, additional, Eckert, Alexander, additional, Bell, R Bryan, additional, Cheng, Allen, additional, Bui, Tuan, additional, Leidner, Rom, additional, Bifulco, Carlo, additional, Wickenhauser, Claudia, additional, Fox, Bernard A, additional, and Seliger, Barbara, additional
Published: 2015
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35. An evaluation of autologous tumor-reactive TIL generation from head and neck squamous cell cancers

Author: Carlo Bifulco, Walter J. Urba, Brendan D. Curti, Rom Leidner, Tarsem Mougdil, Bernard Fox, Christopher Dubay, Christopher Paustian, Zipei Feng, Hong-Ming Hu, and Brian Bell
Subjects: Pharmacology, Oncology, Cancer Research, medicine.medical_specialty, Squamous cell cancer, business.industry, Incidence (epidemiology), medicine.medical_treatment, Immunology, Cancer, Immunotherapy, medicine.disease, Bioinformatics, Head and neck squamous-cell carcinoma, stomatognathic diseases, Internal medicine, Poster Presentation, medicine, Molecular Medicine, Immunology and Allergy, business, Head and neck, Autologous tumor
Abstract: Meeting abstracts Head and neck squamous cell carcinoma (HNSCC) is the 6th leading cause of cancer by incidence worldwide with approximately 600,000 new cases per year. While some patients respond to immunotherapy, the majority of patients fail to experience benefit. Our group formed a
Published: 2015

36. New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31st Annual Meeting of the Society for Immunotherapy of Cancer, 2016.

Author: Adusumilli, Prasad S., Cha, Edward, Cornfeld, Mark, Davis, Thomas, Diab, Adi, Dubensky Jr., Thomas W., Evans, Elizabeth, Grogan, Jane L., Irving, Bryan A., Leidner, Rom S., Olwill, Shane A., Soon-Shiong, Patrick, Triebel, Frederic, Tuck, David, Bot, Adrian, Dansey, Roger D., Drake, Charles G., Freeman, Gordon J., Ibrahim, Ramy, and Patel, Salil
Subjects: IMMUNOTHERAPY, CANCER treatment, DRUG development, CONFERENCES & conventions
Abstract: This report is a summary of 'New Cancer Immunotherapy Agents in Development' program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland. Presenters gave brief overviews of emerging clinical and pre-clinical immune-based agents and combinations, before participating in an extended panel discussion with multidisciplinary leaders, including members of the FDA, leading academic institutions and industrial drug developers, to consider topics relevant to the future of cancer immunotherapy. [ABSTRACT FROM AUTHOR]
Published: 2017
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37. OX40 and other immunoregulatory molecules are highly expressed on tumor infiltrating lymphocytes in oral, head and neck squamous cell carcinoma

Author: Montler, Ryan, primary, Bell, Richard B, additional, Leidner, Rom, additional, Crittenden, Marka, additional, Bui, Tuan, additional, Cheng, Allen, additional, Patel, Ashish, additional, Tucker, Christopher, additional, Thalhofer, Colin, additional, and Weinberg, Andrew, additional
Published: 2014
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38. Characterizing the immunoprofile and endogenous immune response to squamous cell carcinomas of the head and neck to guide development of effective immunotherapy strategies

Author: Moudgil, Tarsem, primary, Bell, R Bryan, additional, Leidner, Rom, additional, Feng, Zipei, additional, Paustian, Christopher, additional, Dubay, Christopher, additional, Hilton, Traci L, additional, Curti, Brendan, additional, Urba, Walter J, additional, Bifulco, Carlo B, additional, Hu, Hong-Ming, additional, and Fox, Bernard A, additional
Published: 2014
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39. OX40 and other immunoregulatory molecules are highly expressed on tumor infiltrating lymphocytes in oral, head and neck squamous cell carcinoma

Author: Marka R. Crittenden, Andrew D. Weinberg, Richard Bryan Bell, Ryan Montler, Colin Thalhofer, Christopher G. Tucker, Allen C. Cheng, Ashish Patel, Tuan Bui, and Rom Leidner
Subjects: Pharmacology, Cancer Research, Tumor microenvironment, business.industry, Tumor-infiltrating lymphocytes, T cell, Immunology, FOXP3, hemic and immune systems, chemical and pharmacologic phenomena, medicine.disease, Primary tumor, Immune system, medicine.anatomical_structure, Oncology, Poster Presentation, Molecular Medicine, Immunology and Allergy, Medicine, Cytotoxic T cell, IL-2 receptor, business
Abstract: OX40 is a potent co-stimulatory receptor on the surface of T lymphocytes. An OX40 agonist was recently tested in a Phase I clinical trial and was found to be well tolerated and enhanced both humoral and cellular immunity in patients with metastatic cancer. Both PD-1 and CTLA-4 blockade are showing therapeutic clinical activity in late stage cancer patients. Hence, we hypothesize that the immune suppressed tumor microenvironment that characterizes oral, head and neck squamous cell carcinoma (OHNSCC) can be overcome by strategies that favor antitumor inflammatory T cell responses and may be an ideal tumor site for immune modulation. This investigation aims to provide a better understanding of the expression of OX40, PD-1, CTLA-4 and CD103 in OHNSCC tumor infiltrating lymphocytes (TIL). Additionally we evaluated whether phenotypic differences existed in patients with HPV positive vs. negative status. Methods TIL and autologous blood were isolated from 29 patients undergoing surgery for OHNSCC. A sample of tissue was obtained from the resection specimen of the primary tumor and sent to the laboratory with autologous blood. Tumor was minced and subjected to digestive enzymes. Blood and tumor samples were separated over ficoll gradient to enrich for lymphocytes. Samples were frozen at -140°c and later thawed in batches for analysis. Proteins were then labeled with fluorescently conjugated antibodies and analyzed by flow cytometry. Results The percentage of FoxP3+CD25+CD4+ (Tregs) of CD4+ T cells is significantly higher in OHNSCC Tumor Infiltrating Lymphocytes (TIL) compared to blood (p < .0005), regardless of HPV status. OX40 expression is significantly higher in the TIL Treg population relative to blood Tregs (p < .0005), also independent of HPV status. PD1 expression is increased in the Tregs (p < .0005), conventional CD4 (p=.0066), and CD8 T cells (p < .0005), in TIL relative to blood. CTLA-4 expression is increased in TIL relative to blood in all subsets with the highest expression observed in the Treg population (.0056). CD103 expression is increased on CD8 T cells in TIL relative to blood (p < .0005). CD8s from HPV positive patients have higher percentage CD103 positive cells than CD8s from HPV negative patients (p=.0056). The highest percentages of PD-1, CTLA-4 and OX40 triple positive cells were found in the Treg population of TIL compared to blood (p < .0005). Due to increased expression of OX40, CTLA-4 and PD-1 in TIL of OHNSCC patients we hypothesize that future combination clinical trials that target these pathways will be therapeutically beneficial.
Published: 2014

40. Characterizing the immunoprofile and endogenous immune response to squamous cell carcinomas of the head and neck to guide development of effective immunotherapy strategies

Author: Hong-Ming Hu, Walter J. Urba, Zipei Feng, Carlo Bifulco, Traci L Hilton, Tarsem Moudgil, Bernard A. Fox, Rom Leidner, R. Bryan Bell, Brendan D. Curti, Christopher Paustian, and Christopher Dubay
Subjects: Cancer Research, T cell, medicine.medical_treatment, Immunology, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Immunology and Allergy, Pharmacology, Tumor microenvironment, business.industry, Microvesicle, Head and neck cancer, Cancer, 030206 dentistry, Immunotherapy, medicine.disease, Microvesicles, 3. Good health, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Poster Presentation, Cancer research, Molecular Medicine, business
Abstract: Squamous cell carcinoma of the head and neck (HNSCC) is the 6th leading cause of cancer by incidence worldwide with approximately 600,000 new cases per year. Unfortunately, only 40-50% of these patients will survive for 5 years. In order to study the immune response in patients with this disease we have developed a HNSCC tumor bank to compliment our Oral, Head and Neck Cancer Program. This tumor bank is cryopreserving enzymatically isolated viable cells from resected tumors (n = 128). We are also attempting to develop primary cell lines (10 lines established) and are isolating and assessing tumor-specific function of tumor-infiltrating lymphocytes (TIL) (n = 49). Since HNSCC can express immune inhibitory molecules and secrete suppressive factors, we are developing single stains and multi-spectral imaging protocols to assess the immune contexture of the tumor microenvironment by immunohistochemistry and immunoflouresence and are overlaying these studies with T cell functional activity and ultimately, with clinical outcome. Preliminary analyses suggest that tumor-specific T cells can be detected in 68% (N = 16) of patients evaluated. A goal of these studies is to identify strategies that will allow tailoring of therapy for patients with HNSCC. One component is to identify which inhibitors are present in a given tumor. Since not every tumor appears to contain TIL capable of recognizing autologous tumor, strategies to prime tumor-specific T cells represents another area of interest. DPV-001 is a microvesicle vaccine, DRibbles, that contains an average of at least 66 proteins that are overexpressed by HNSCC (TCGA provisional RNASeq n = 303 pts). The vaccine also contains multiple DAMPs and agonist activity for TLR 2, 3, 4, 7 and 9 packed into stable double membrane microvesicles that are targeted to CLEC9A+ APC. To increase potential activity against HPV positive cancers we have developed a mosaic construct encoding E6 and E7 peptides for a number of HPV strains and are evaluating both protein and gene-based HPV vaccine strategies. We are using the HNSCC TIL lines to evaluate DRibble vaccines and potential for adoptive immunotherapy trials. Support: NCI U43CA165048 and R44 CA121612 (TLH), OMS (HH, RBB), Steve and Cindy Harder, Robert W. and Elsie Franz, Wes and Nancy Lematta, Lynn and Jack Loacker, and The Chiles foundation (BAF).
Published: 2014

41. Developing an immunotherapy strategy for the effective treatment of patients with squamous cell carcinoma of the head and neck

Author: Moudgil, Tarsem, primary, Bell, R Bryan, additional, Leidner, Rom, additional, Van de Ven, Rieneke, additional, Feng, Zipei, additional, Affentoulis, Michael, additional, Paustian, Christopher, additional, Dubay, Christopher, additional, Hilton, Traci L, additional, Urba, Walter J, additional, Hu, Hong-Ming, additional, Bifulco, Carlo B, additional, and Fox, Bernard A, additional
Published: 2013
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42. Novel strategy to monitor apparent tumor-specific T cells in patients with cancer

Author: van de Ven, Rieneke, primary, Hilton, Traci L, additional, Dubay, Christopher J, additional, Puri, Sachin, additional, Hu, Hong-Ming, additional, Leidner, Rom S, additional, Bell, R Bryan, additional, Urba, Walter J, additional, Curti, Brendan D, additional, Aung, Sandra, additional, and Fox, Bernard A, additional
Published: 2013
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43. Developing an immunotherapy strategy for the effective treatment of patients with squamous cell carcinoma of the head and neck

Author: Carlo Bifulco, Walter J. Urba, Tarsem Moudgil, Zipei Feng, Traci L Hilton, Michael Affentoulis, Christopher Dubay, R. Bryan Bell, Rieneke van de Ven, Christopher Paustian, Rom Leidner, Hong-Ming Hu, and Bernard A. Fox
Subjects: Pharmacology, Cancer Research, business.industry, medicine.medical_treatment, T cell, Immunology, Cancer, Immunotherapy, medicine.disease, stomatognathic diseases, Immune system, medicine.anatomical_structure, Oncology, Antigen, Immunity, Poster Presentation, medicine, Molecular Medicine, Immunology and Allergy, Immunohistochemistry, business, CD8
Abstract: Squamous cell carcinoma of the head and neck (HNSCC) arises in the oral cavity, oropharynx, larynx or hypopharynx, and is the 6th leading cause of cancer by incidence worldwide. Approximately 600,000 cases arise each year, and only 40-50% of these patients will survive for 5 years.7 HNSCC can express PD-L1 and suppressive factors that interfere with the differentiation and activation of dendritic cells and effector function of T cells. Similar to observations in other malignancies, CD8 effector T cell infiltration or transcriptional signature consistent with an ongoing T cell response is associated with prolonged survival. This suggests that HNSCC lacking a T cell infiltrate may benefit from immune interventions that induce and/or augment a tumor-specific immune response. To develop a strategy to address this problem we have created a HNSCC tumor bank that is cryopreserving enzymatically isolated viable cells from resected tumors (39 specimens). We are also attempting to develop primary cell lines (4 lines established) and are isolating tumor-infiltrating lymphocytes from these specimens. We are looking to compare immunohistochemical, flowcytometric and functional analyses of these specimens. Consistent with previous studies, results document that isolated TIL secrete IFN-γ when stimulated with their autologous tumor cells (n=2). Since a central aim of these studies is to develop a strategy to create therapeutic immunity in patients lacking T cell infiltrates, we plan to investigate which antigens are recognized and whether, antigens present in a novel DRibble vaccine, that expresses antigens common to HNSCC, are recognized by these TIL. This may provide a strategy to monitor anti-tumor immunity in these patients and possibly provide an antigen source for combination immunotherapy of patients with HNSCC.
Published: 2013

44. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Author: Althammer, Sonja, Steele, Keith, Rebelatto, Marlon, Tan, Tze Heng, Wiestler, Tobias, Schmidt, Guenter, Higgs, Brandon, Li, Xia, Shi, Li, Jin, Xiaoping, Antal, Joyce, Gupta, Ashok, Ranade, Koustubh, Binning, Gerd, Bellmunt, Joaquim, de Wit, Ronald, Vaughn, David J., Fradet, Yves, Lee, Jae Lyun, Fong, Lawrence, Vogelzang, Nicholas J., Climent, Miguel A., Petrylak, Daniel P., Choueiri, Toni K., Necchi, Andrea, Gerritsen, Winald, Gurney, Howard, Quinn, David I., Culine, Stéphane, Sternberg, Cora N., Mai, Yabing, Puhlmann, Markus, Perini, Rodolfo F., Bajorin, Dean F., Sharma, Padmanee, Callahan, Margaret K., Calvo, Emiliano, Kim, Joseph W., de Braud, Filipo, Ott, Patrick A., Bono, Petri, Pillai, Rathi N., Morse, Michael, Le, Dung T., Taylor, Matthew, Spilliopoulou, Pavlina, Bendell, Johanna, Jaeger, Dirk, Chan, Emily, Antonia, Scott J., Ascierto, Paolo A., Hennicken, Delphine, Tschaika, Marina, Azrilevich, Alex, Rosenberg, Jonathan, Levy, Ofer, Chan, Christopher, Cojocaru, Gady, Liang, Spencer, Ophir, Eran, Ganguly, Sudipto, Toporik, Amir, Kotturi, Maya, Kfir, Tal Fridman, Murter, Benjamin M., Logronio, Kathryn, Dassa, Liat, Leung, Ling, Greenwald, Shirley, Azulay, Meir, Kumar, Sandeep, Alteber, Zoya, Pan, Xiaoyu, Machlenkin, Arthur, Benita, Yair, Drake, Andrew W., Chajut, Ayelet, Salomon, Ran, Vankin, Ilan, Safyon, Einav, Hunter, John, Levine, Zurit, White, Mark, Leidner, Rom, Kang, Hyunseok, Haddad, Robert, Segal, Neil H., Wirth, Lori J., Ferris, Robert L., Hodi, F. Stephen, Sanborn, Rachel E., Gajewski, Thomas F., Sharfman, William, McDonald, Dan, Srivastava, Shivani, Gu, Xuemin, Phillips, Penny, Passey, Chaitali, Seiwert, Tanguy, Habtetsion, Tsadik, Zhou, Gang, Sakellariou-Thompson, Donastas, Haymaker, Cara, Creasy, Caitlin, Hurd, Mark, Uraoka, Naohiro, Canales, Jaime Rodriguez, Koptez, Scott, Hwu, Patrick, Maitra, Anirban, Bernatchez, Chantale, Coyle, Scott M., Roybel, Kole T., Rupp, Levi J., Santoro, Stephen P., Secrest, Stephanie, Spelman, Michael, Ho, Hanson, Gomes, Tina, Tse, Tiffany, Yung-Wu, Chia, Taunton, Jack, Lim, Wendell, Emtage, Peter, Moudgil, Tarsem, Ballesteros-Merino, Carmen, Hilton, Traci, Paustian, Christopher, Page, David, Urba, Walter, Fox, Bernard, Bell, Bryan, Patel, Ashish, Olafsen, Tove, Satpayev, Daulet, Torgov, Michael, Marchioni, Filippo, Romero, Jason, Jiang, Ziyue Karen, Zamilpa, Charles, Keppler, Jennifer S., Mascioni, Alessandro, Jia, Fang, Lee, Chen-Yu, Gudas, Jean, Sullivan, Ryan J., Hoshida, Yujin, Logan, Theodore, Khushalani, Nikhil, Giobbie-Hurder, Anita, Margolin, Kim, Roder, Joanna, Bhatt, Rupal, Koon, Henry, Olencki, Thomas, Hutson, Thomas, Curti, Brendan, Blackmon, Shauna, Mier, James W., Puzanov, Igor, Roder, Heinrich, Stewart, John, Amin, Asim, Ernstoff, Marc S., Clark, Joseph I., Atkins, Michael B., Kaufman, Howard L., Sosman, Jeffrey, Signoretti, Sabina, McDermott, David F., Anderson, Abraham A., Milhem, Mohammed M., Andtbacka, Robert H. I., Minor, David, Gorski, Kevin S., Baker, Daniel M., Hamid, Omid, Akporiaye, Emmanuel, Koguchi, Yoshinobu, Sutcliffe, Kim, Conder, Kristie, Marron, Thomas, Bhardwaj, Nina, Hammerich, Linda, George, Fiby, Kim-Schulze, Seunghee, Keler, Tibor, Davis, Tom, Crowley, Elizabeth, Salazar, Andres, Brody, Joshua, Monjazeb, Arta, Daly, Megan E., Riess, Jonathan, Li, Tianhong, Murphy, William J., Kelly, Karen, Hu, Zhiwei, Shen, Rulong, Campbell, Amanda, McMichael, Elizabeth, Yu, Lianbo, Ramaswam, Bhuvaneswari, London, Cheryl A., Xu, Tian, Carson, William, Kokolus, Kathleen M., Repasky, Elizabeth A., Schell, Todd D., Drabick, Joseph D., Messenheimer, David J., Jensen, Shawn, Rubinstein, Mark, Andrijauskaite, Kristina, Swiderska-syn, Marzena, Lind, Kristin, Choppin, Agnes, Roell, Marina K., Wrangle, John, Rhode, Peter, Wong, Hing, Ahmad, Shamim, Webb, Mason, Abu-Eid, Rasha, Shrimali, Rajeev, Verma, Vivek, Doroodchi, Atbin, Berrong, Zuzana, Yashar, David, Samara, Raed, Mkrtichyan, Mikayel, Khleif, Samir, Powell, Steven, Gitau, Mark, Sumey, Christopher, Terrell, Andrew, Lohr, Michele, Nowak, Ryan K., McGraw, Steven, Jensen, Ash, Blanchard, Miran, Gold, Kathryn A., Cohen, Ezra E. W., Ellison, Christie, Black, Lora, Lee, John, Spanos, William Chad, Wennerberg, Erik, Schwitzer, Emily, Lhuillier, Claire, Koelwyn, Graeme, Hiner, Rebecca, Jones, Lee, Demaria, Sandra, Amanda, Vandeveer, Greiner, John W., Schlom, Jeffrey, Bookstaver, Michelle, Jewell, Christopher M., Gunderson, Andrew, Boulmay, Brian, Li, Rui, Spieler, Bradley, Happel, Kyle, Feng, Zipei, Dubay, Christopher, Fisher, Brenda, Aung, Sandra, Mederos, Eileen, Bifulco, Carlo B., McNamara, Michael, Bahjat, Keith, Redmond, William, Ochoa, Augusto, Hu, Hong-Ming, Mehta, Adi, Lund-Johansen, Fridtjof, Bedu-Addo, Frank, Conn, Greg, King, Michael, Dutta, Panna, Shepard, Robert, Einstein, Mark, Adams, Sylvia, Wang, Ena, Jin, Ping, Novik, Yelena, Morrison, Debra, Oratz, Ruth, Marincola, Franco M., Stroncek, David, Goldberg, Judith, Formenti, Silvia C., Galon, Jérôme, Mlecnik, Bernhard, Marliot, Florence, Ou, Fang-Shu, Lugli, Alessandro, Zlobec, Inti, Rau, Tilman T., Nagtegaal, Iris D., Vink-Borger, Elisa, Hartmann, Arndt, Geppert, Carol, Roehrl, Michael H., Bavi, Prashant, Ohashi, Pamela S., Wang, Julia Y., Nguyen, Linh T., Han, SeongJun, MacGregor, Heather L., Hafezi-Bakhtiari, Sara, Wouters, Bradley G., Kawakami, Yutaka, Papivanova, Boryana, Xu, Mingli, Fujita, Tomonobu, Hazama, Shoichi, Suzuki, Nobuaki, Nagano, Hiroaki, Okuno, Kiyotaka, Itoh, Kyogo, Zavadova, Eva, Vocka, Michal, Spacek, Jan, Petruzelka, Lubos, Konopasek, Bohuslav, Dundr, Pavel, Skalova, Helena, Torigoe, Toshihiko, Sato, Noriyuki, Furuhata, Tomohisa, Takemasa, Ichiro, Van den Eynde, Marc, Jouret-Mourin, Anne, Machiels, Jean-Pascal, Fredriksen, Tessa, Lafontaine, Lucie, Buttard, Bénédicte, Church, Sarah, Maby, Pauline, Angell, Helen, Angelova, Mihaela, Vasaturo, Angela, Bindea, Gabriela, Berger, Anne, Lagorce, Christine, Patel, Prabhu S., Vora, Hemangini H., Shah, Birva, Patel, Jayendrakumar B., Rajvik, Kruti N., Pandya, Shashank J., Shukla, Shilin N., Wang, Yili, Zhang, Guanjun, Masucci, Giuseppe V., Andersson, Emilia K., Grizzi, Fabio, Laghi, Luigi, Botti, Gerardo, Tatangelo, Fabiana, Delrio, Paolo, Cilberto, Gennaro, Marincola, Franco, Sargent, Daniel J., Fox, Bernard A., Algazi, Alain, Tsai, Katy, Rosenblum, Michael, Nandoskar, Prachi, Li, Amy, Nonomura, John, Takamura, Kathryn, Dwyer, Mary, Browning, Erica, Talia, Reneta, Twitty, Chris, Gargosky, Sharron, Campbell, Jean, Le, Mai, Pierce, Robert H., Daud, Adil, Gartrell, Robyn, Marks, Douglas, Stack, Edward, Lu, Yan, Izaki, Daisuke, Beck, Kristen, Jia, Dan Tong, Armenta, Paul, White-Stern, Ashley, Fu, Yichun, Blake, Zoe, Taback, Bret, Horst, Basil, Saenger, Yvonne M., Leonardo, Steven, Gorden, Keith, Fulton, Ross B., Fraser, Kathryn, Kangas, Takashi O., Walsh, Richard, Ertelt, Kathleen, Graff, Jeremy, Uhlik, Mark, Sims, Jennifer S., Lei, Liang, Tsujiuchi, Takashi, Bruce, Jeffrey N., Canoll, Peter, Tolcher, Anthony W, Alley, Evan W, Chichili, Gurunadh, Canoll, Jan E, Moore, Paul, Bonvini, Ezio, Johnson, Syd, Shankar, Sadhna, Vasselli, James, Wigginton, Jon, and Powderly, John
Subjects: Meeting Abstracts
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45. Novel strategy to monitor apparent tumor-specific T cells in patients with cancer

Author: Sachin Puri, Walter J. Urba, Rom Leidner, Brendan D. Curti, Sandra Aung, R. Bryan Bell, Traci L Hilton, Rieneke van de Ven, Christopher Dubay, Hong-Ming Hu, and Bernard A. Fox
Subjects: Cancer Research, medicine.medical_treatment, Immunology, Tumor specific, 03 medical and health sciences, Interleukin 21, 0302 clinical medicine, Immune system, Antigen, medicine, Immunology and Allergy, In patient, 030304 developmental biology, Pharmacology, 0303 health sciences, business.industry, Cancer, Immunotherapy, medicine.disease, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Poster Presentation, Molecular Medicine, business, Autologous tumor
Abstract: Meeting abstracts We hypothesize that immune responses that develop following immunotherapy, particularly in patients with objective responses, are directed against a wide range of antigenic determinants. However, in the absence of autologous tumor cells, monitoring is frequently limited to a small
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